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   2016| April-June  | Volume 35 | Issue 4  
    Online since August 10, 2016

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Ulcer healing potential of ethanolic extract of Caralluma attenuata on experimental diabetic rats
Sunil Garg, Sajal Srivastava, Kisanpal Singh, Alok Sharma, Kavita Garg
April-June 2016, 35(4):222-226
DOI:10.4103/0257-7941.188182  PMID:27621520
Introduction: Available data indicated that diabetes mellitus (DM) increases the vulnerability of the gastric ulcers and the need of the hour is to develop effective agents to treat ulcer with diabetes for better patient compliance and cost effectiveness. The ulcer-healing properties of ethanolic extract of Caralluma attenuata (CAEt) against both chemically- and physically induced gastric ulcers in experimental rats are recently studied. Aim: To assess the ulcer healing potential of Ethanolic Extract of Caralluma attenuata on Experimental Diabetic Rats. Material and Methods: The current study aimed to evaluate ulcer healing properties of CAEt on the aspirin induced gastric ulcer in rats with streptozotocin induced DM. The hypothesis is based on the fact that DM results in compromising the mucosal defensive factors associated with delay in gastric ulcer healing, and if these changes can be corrected by using agents known for their antidiabetic and antiulcer properties. Experimental albino rats were divided into six groups. Except for Group I, other groups contained streptozotocin-induced diabetic rats. Group I (normal control) and Group II (diabetic control) were administered vehicle, Groups III and IV (diabetic experimental) were administered CAEt in dose of 100 mg/kg and 250 mg/kg, respectively, and Groups V and VI (positive controls) were respectively administered oral standard drugs omeprazole, 20 mg/kg, and tolbutamide 10 mg/kg. Result: The results confirmed that the CAEt significantly decreases the ulcer index (P < 0.05) in the aspirin-induced gastric ulcers and also significantly exhibit antioxidant and glucose lowering activity in the diabetic ulcer rats. The study showed that C. attenuata has the potential to be used as an antiulcer agent in experimental diabetic rats.
  3 3,366 99
Efficacy of Nasya (nasal medication) in coma: A case study
Rajkala S Ramteke, Panchakshari D Patil, Anup B Thakar
April-June 2016, 35(4):232-235
DOI:10.4103/0257-7941.188188  PMID:27621522
For emergency conditions, Ayurveda has never been given importance in recent times. However, there are certain emergency conditions where biomedicine has limitations but, Ayurveda can provide solution. Classics have many references regarding management of acute conditions like syncope, coma, episodic conditions of bronchial asthma, epilepsy, etc., In the present study, a 61 year female patient had a two year history of hypertension and was suffering with coma. She was treated with an Ayurvedic treatment modality. Nasya (nasal medication) of Trikaṭu cūrṇa (powder) for seven days, followed by dhūmapāna (~fumigation) with saṅkhyāsthāpana (consciousness restorative) drugs for seven days was administered. The outcome of this management was appreciable, as it resulted in positive changes in Glasgow Coma Scale (GSCS) from 3 to 11.
  2 4,251 212
Intelligence quotient and concept of Deha-Mānasa Prakṛti in Ayurveda
Vijaykumar Nandvadekar, Sandeep V Binorkar
April-June 2016, 35(4):201-206
DOI:10.4103/0257-7941.188184  PMID:27621516
Background: Ayurveda has classified humans according to Deha-Mānasa prakṛti. It has given equal emphasis to both physical and psychological status of the individual. Constitution or configuration is an individual's peculiar set up of body and mind. It is also of importance in etiopathogenesis, prognosis and treatment procedures of various ailments. It is said that nature has its relative roles in causing individual and group differences in their respective cognitive abilities. Aim: The present study was designed to validate and assess the Intelligence Quotient of individuals of different Prakṛtis . Materials and Methods: A study was conducted in healthy individuals of age 20-30 years, divided into three groups depending on their Deha-Mānasa Prakṛtis and thereafter assessed for their individual IQ. Conclusion: This article highlights the comparative outcome and relation between Deha-mānasa prakṛti and intelligence of an individual. It is observed that IQ is more in kapha prakṛti , moderate in pitta prakṛti and least in vāta prakṛti individuals.
  2 4,343 171
Hypoglycemic and anti-hyperglycemic activity of Triphalādi granules in mice
Ankush Gunjal, Manisha Walunj, Hetal Aghera, Mukesh Nariya, Mandip R Goyal
April-June 2016, 35(4):207-211
DOI:10.4103/0257-7941.188177  PMID:27621517
Background: Triphalādi kvātha is well known herbal Ayurvedic formulation used in Prameha (~type 2 diabetes mellitus). In the present study, kvātha was converted into granules and assessed for its hypoglycemic and anti-hyperglycemic effects in albino mice. Materials and Methods: Triphalādi granules (650 mg/kg, p.o.) were administered in normal albino mice for assessment of hypoglycemic activity. Anti-hyperglycemic activity of Triphalādi granules was assessed in glucose (5 g/kg, p.o.) solution overloaded mice. The blood sugar level (BSL) was measured with the help of one touch easy glucometer. Results: Triphalādi granules produced significant decrease in blood glucose level after one hour in comparison to initial values while decreasing BSL by 27.92% in comparison to control group in normal albino mice. In hyperglycemic study, Triphalādi granules produced significant decrease the BSL after 2 hr. of administration compared to control group. Conclusion: Triphalādi granules have significant hypoglycemic and anti-hyperglycemic activity in mice with minimal effect on BSL below normal range. The studies suggest the potential role of Triphalādi granules as an alternative adjuvant therapy in diabetic individuals for the control of the blood glucose level.
  2 3,573 131
General unknown screening, antioxidant and anti-inflammatory potential of Dendrobium macrostachyum Lindl.
Nimisha Pulikkal Sukumaran, R Hiranmai Yadav
April-June 2016, 35(4):240-244
DOI:10.4103/0257-7941.188181  PMID:27621524
Context: D. macrostachyum is an epiphytic orchid abundant in Southern India and is reported for pain relief in folklore. Aims: The objective of the present study was to determine in vitro free radical scavenging and anti-inflammatory activity of D. macrostachyum and to perform LCMS based metabolic profiling of the plant. Settings and Design: Sequential stem and leaf extracts were assessed for its antioxidant and anti-inflammatory activity by in vitro methods. Materials and Methods: The antioxidant activity determined by assays based on the decolourization of the radical monocation of DPPH, ABTS and reducing power. Total amount of phenolics for quantitative analysis of antioxidative components was estimated. In vitro anti-inflammatory activity was evaluated using protein denaturation assay, membrane stabilization assay and proteinase inhibitory activity. Methanolic extract of plant was subjected to LCMS. Results: The stem ethanolic extracts exhibited significant IC50value of 10.21, 31.54 and 142.97 μg/ml respectively for DPPH, ABTS radical scavenging and reducing power activity. The ethanol and water extract was highly effective as albumin denaturation inhibitors (IC50 = 114.13 and 135.818 μg/ml respectively) and proteinase inhibitors (IC50 = 72.49 and 129.681 μg/ml respectively). Membrane stabilization was also noticeably inhibited by the stem ethanolic extract among other extracts (IC50 = 89.33 μg/ml) but comparatively lower to aspirin standard (IC50 = 83.926 μg/ml). The highest total phenol content was exhibited by ethanolic stem and leaf extracts respectively at 20 and 16 mg of gallic acid equivalents of dry extract. On LCMS analysis 20 constituents were identified and it included chemotaxonomic marker for Dendrobium species. Conclusions: The results showed a relatively high concentration of phenolics, high scavenger activity and high anti-inflammatory activity of the stem extract compared to the leaf extract. The results indicate that the plant can be a potential source of bioactive compounds.
  2 3,309 93
Ayurvedic management of cirrhotic ascites
G Aswathy, Prasanth Dharmarajan, Ananth Ram Sharma, VK Sasikumar, MR Vasudevan Nampoothiri
April-June 2016, 35(4):236-239
DOI:10.4103/0257-7941.188183  PMID:27621523
Cirrhosis is the final stage of most of the chronic liver diseases and is most invariably complicated by portal hypertension resulting in ascites. A case of chronic liver disease with portal hypertension (cryptogenic cirrhosis), managed at Amrita School of Ayurveda is discussed in this paper. The clinical picture was that of an uncomplicated cirrhotic ascites. Snehapāna (therapeutic oral administration of lipids) followed by virecana (purgation) was done after an initial course of nityavirecana (daily purgation). Later Vardhamāna pippalī rasāyana [administration of single drug - pippalī (piper longum) in a structured dose pattern] was administered with an intention of rejuvenating liver cells. Ascites and lower limb oedema were completely resolved after the therapy. No recurrence of ascites has been reported after a follow up period of one year.
  1 3,900 211
Workshop on research methodology for Ayurveda, April 2 and 3, 2016
Amit Nakanekar
April-June 2016, 35(4):253-254
DOI:10.4103/0257-7941.188187  PMID:27621527
  1 2,665 99
Morbidity profile of elderly outpatients attending selected sub-district Siddha health facilities in Tamil Nadu, India
Kalaiselvi Selvaraj, Manikandan Srinivasan, Venkatachalam Duraisamy, Gomathi Ramaswamy, Vinayagamurthy Venugopal, Palanivel Chinnakali
April-June 2016, 35(4):212-216
DOI:10.4103/0257-7941.188178  PMID:27621518
Background: Recently, under National Health Mission alternate systems of Medicine are mainstreamed in public health care system. Effective action plan generation, logistic arrangement and roll out of these alternate systems of Medicine needs understanding on profile of morbidities among attendees who come to these facilities. Objectives: This study was planned to report profile of morbidities, age and sex differentials in specific morbidities among geriatric attendees in secondary level siddha health facilities. Materials and Methods: A facility based cross sectional study was conducted among elderly person (60 years and above) attending Siddha outpatient department (OPD) from two of the randomly selected sub district level siddha facilities in Erode district, Tamil Nadu, India. Information on socio-demographic variables like age, gender, education and clinical profile (diagnosis) were collected from records already maintained in the siddha OPD. Morbidities were summarized in terms of proportions based on age and gender. Age and sex specific differentials on specific morbidities were compared using 'z' test. Results: Of 2710 patients who visited these two siddha facilities during the reference period, 763 (28.1%) patients were elderly. Arthritis (45.2%), neuritis (8.8%), diabetes (6.6%), bronchial asthma (5.2%), hemiplegia (3.7%) were the top five morbidities diagnosed and treated among elderly attending the siddha OPD. There was a predilection towards elderly male for morbidities such as bronchial asthma and hemiplegia compared to elderly female. Similarly, higher proportions of lumbar spondylosis, hypertension and fungal skin diseases were reported among aged 80 years or more compared to elderly aged 60-79 years. Conclusion: Elderly constitute more than one fourth of outpatients load from siddha health facilities. Degenerative diseases like arthritis and non-communicable diseases were the common morbidities in this age group. Geriatric clinics and mobile clinics under siddha system may help in improving health care services.
  1 3,624 146
Clinical efficacy of certain Unani herbs in knee osteoarthritis: A pretest and post-test evaluation study
Asfia Tarannum, Arshiya Sultana, Khaleeq Ur Rahman
April-June 2016, 35(4):227-231
DOI:10.4103/0257-7941.188185  PMID:27621521
Objectives: This study was conducted to evaluate the efficacy of preparations of certain Unani herbs on Lequesne Algo-Functional Index of knee osteoarthritis (OA). Materials and Methods: A prospective, pre- and post test evaluation study was conducted on 20 diagnosed patients of OA recruited from the Nizamia General Hospital, Hyderabad. Internally, a combination (formula) of Unani herbs was administered, which was as follows: 3.5 g powder of Asarun (2 g), Tukhme karafs (2 g), and Filfil daraz (3 g) was administered internally twice daily. Externally, the concoction of Gule baboona (20 g) and Gule tesu (40 g) made in 1 l water was poured over the affected knee, daily once for 40 days. The primary outcome was to assess the efficacy of Unani test drugs with the modified Lequesne Algo-Functional Index for knee OA. Results: The mean percentage reduction of Lequesne Algo-Functional Index score was 71.09%. The mean and standard deviation was 10.55 (1.70) and 3.05 (2.30) before treatment and after treatment, respectively. The pre- and post test evaluation showed reduction in Lequesne Algo-Functional Index score (P < 0.0001). Conclusion: In this study, the Unani treatment module was found to be effective in reducing the severity of disease in patients with osteoarthritis of knees.
  1 3,708 121
A proposal for inclusion of Indology in regular school curriculum
Sanchit Misra
April-June 2016, 35(4):251-252
DOI:10.4103/0257-7941.188180  PMID:27621526
  1 2,749 79
Snake bite treatment in Prayoga samuccayam
Ittoop Jacob Ancheril, T Sharanesh, K Naveen, V Deepthi
April-June 2016, 35(4):245-248
  - 3,167 156
Evidence for ayurvedic products' efficacy: The devil is in details
D. B. A. Narayana
April-June 2016, 35(4):193-194
DOI:10.4103/0257-7941.188176  PMID:27621514
  - 5,039 202
Botanical identification of plants described in Mādhava Cikitsā for the treatment of diarrhoea
Niteen Ramdas Salve, Debendranath Mishra
April-June 2016, 35(4):195-200
DOI:10.4103/0257-7941.188179  PMID:27621515
Context: Mādhava is regarded as a 7th century Indian Physician who composed two treatises (in Sanskrit) on Ayurveda, the Mādhava Nidāna and Mādhava Cikitsā. The former treatise deals with the diagnosis of diseases while the latter with the treatment using medicinal plants and other recipes. In Mādhava Cikitsā , a common Sanskrit name is found to describe two or more totally different botanical plant species (thus leading to ambiguity) and a distinct botanical species is also found to represent two or more Sanskrit names at several instances. Aims: The present paper deals with the correct botanical identification (most probable) of Sanskrit named plants described in Mādhava Cikitsā for the treatment of Diarrhoea (Atisāra Cikitsā). Subjects and Methods: The authentic manuscripts of 'Mādhava Cikitsā' were critically studied for the present research outcome. A detailed literature survey is carried out from various references and texts. Results: The list of Sanskrit named plants contains 103 names, while after the critical study and assigning the most probable botanical identification as per ICBN, the list of plant species described in the text for the treatment of Diarrhoea is found to contain 73 names. Conclusions: The present study will certainly benefit Ayurvedic medical practitioners and pharmaceutical companies in selection of proper plant species avoiding substitutions for drug formulation.
  - 3,528 199
Effect of Karamardādi yoga versus diclofenac sodium in post-operative pain management: A randomized comparative clinical trial
Rahul Hegana, Hemant Devaraj Toshikhane, Sangeeta Toshikhane, Hetal Amin
April-June 2016, 35(4):217-221
DOI:10.4103/0257-7941.188174  PMID:27621519
Introduction: Post-operative pain is Nociceptive i.e., anticipated unavoidable physiological pain which is caused due to tissue trauma. Drugs such as NSAIDs (Non Steroidal Anti Inflammatory Drugs) and Opioids are used for post-operative pain management but are associated with their own drawbacks. Karamardādi Yoga has been in use in Ayurvedic practice for analgesia. It is known to relieve pain and can be used to supplement anaesthesia and also get rid of adverse effect of modern analgesic drugs. Aims and Objective: To study the comparative effect of Karamardādi Yoga and Diclofenac sodium in post-operative pain management. Materials and Methods: Randomized clinical trial with Group A (Control Group: Tab Diclofenac sodium 50 mg as a single dose) and Group B (Trial Group: Cap Karamardādi Yoga 500 mg as a single dose). Those who had undergone haemorrhoidectomy operation under local anaesthesia were selected as per inclusion criteria. Vitals, desirable effect and undesirable effect, total surgical time, requirement of 1st dose of analgesic, requirement of rescue analgesic and pain determined by VAS (Visual Analog Scale) were the assessment criteria and were observed and recorded. Results: Karamardādi Yoga does not show any undesirable or serious ill effects and altered values of vitals as per statistical analysis. As per VAS scale, pain felt by Trial group was earlier than control group. Conclusions: Karamardādi Yoga has analgesic property but its analgesic property and pain threshold capacity is lesser than those of Diclofenac sodium.
  - 3,605 127
Author response: Successful treatment of Guillain–Barre syndrome by Ayurvedic treatment
Amit Nakanekar
April-June 2016, 35(4):249-250
DOI:10.4103/0257-7941.188186  PMID:27621525
  - 2,677 99