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   2011| October-December  | Volume 31 | Issue 2  
    Online since September 3, 2012

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A comparative experimental evaluation of anti-inflammatory activity of Premna obtusifolia Linn and Premna latifolia Roxb leaves in Charles foster rats
Harshitha Kumari, P Shrikanth, Chaithra , Reshmi Pushpan, K Nishteswar
October-December 2011, 31(2):58-61
Agnimantha, a classical Ayurvedic drug is one among the dashamoolas, i.e., group of ten plants whose roots form the useful part. It is a main ingredient of many Ayurvedic preparations. Various source plants from the genus Clerodendrum and Premna are used in different regions of the country. In this study, two species of Premna were selected and evaluated for anti-inflammatory activity against carrageenan induced rat hind paw edema. The selected animals were divided into four groups and test drugs were administered orally in the dose of 9ml/kg. Group I received vehicle (distilled water), Group II received leaf decoction of Premna obtusifolia Linn, Group III received leaf decoction of Premna latifolia Roxb and Group IV received indomethacin as standard anti-inflammatory drug. Test drugs and indomethacinwere administered one hour prior to the injection of 0.05 ml of 1% suspension of carrageenan into the sub plantar region of the left hind paw of rats. Study findings indicate that leaves of both the species of Premna have anti-inflammatory potential, P. latifoliabeing superior to P.obtusifolia.
[ABSTRACT]   Full text not available  [PDF]  [Mobile Full text]  [EPub]  [PubMed]
  4,982 186 -
"An experimental study to evaluate the pharmacokinetic aspect of Lekhana Basti (Emaciating/ Desiccating Medicated Enema)"
Swapnil S Auti, BK Ashok, Anup B Thakar, VJ Shukla, B Ravishankar
October-December 2011, 31(2):38-43
Basti therapy is used widely for treatment of various diseases in the field of Ayurveda with several proven clinical applications, however; the exact mechanism through which the benefits are obtained are yet to be ascertained in the light of the contemporary developments in clinical science. It is also not clear that when administered Basti the active principles in the formulation gain entry in to the systemic circulation or not. The present study was planned to acquire some preliminary data with regards to the absorption of phytochemical constituents of the formulations when administered in the form of Basti. Gallic acid was used as marker compound and it's absorption in systemic circulation was assessed using high performance liquid chromatography. Gallic acid present in Lekhana Basti (Emaciating/ Desiccating Medicated Enema) was found to get absorbed in to systemic circulation. Maximum concentration in serum was seen in the animal which received Lekhana Basti with Prakshepa Dravya ( Catalytic Adjuvant) in comparison to animal which received Lekhana Basti without Prakshepa Dravya. Area under curve in chromatogram was also more in animal which received Lekhana Basti with Prakshepa Dravya. From primary evidence created by HPLC study it can be said that, phytochemicals of the Basti formulation do get absorbed in systemic circulation.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  4,505 227 -
Comparative study on Kasisa Bhasma prepared by two different methods
Dhirajsingh Rajput, GS Tekale, BS Patgiri
October-December 2011, 31(2):62-72
Preparation of bhasma (calcined powder of metal/minerals) includes various processing steps like purification (Shodhana), levigation (Bhavana),calcinations cycle(Marana), improving quality and removing blemishes (Amritikarana) etc, processing of bhasma aims at formation of herbo-mineral complex molecule which can act in minimal dosage, palatable, easy for assimilation, highly efficacious with minimal or no complication. Although the most important equipment mentioned for Marana i.e. cow dung cakes and some type of woods are not only difficult to collect but also expensive and create pollution during puta and it's difficult task to give controlled heat in traditional method. Hence, a Modified Portable Bhasma Nirman Yantra (MPBNY) was prepared for puta (equipment for calcination) procedure which is easy to handle, portable and facilitate to supply controlled heat. A comparative study was conducted on Kasisa Bhasma prepared by traditional method and by using MPBNY with special reference to physico-chemical properties. The prepared Kasisa Bhasma was subjected to modern analytical parameters such as A.A.S. (Atomic Absorption Spectroscopy), X.R.D. (X-ray Diffraction) and Ayurvedic parameters eg. Rekhapurnatva (bhasma should enters in between lines of finger), Varitaratva (bhasma should float on the surface of water), Niramlatva (bitter less), Apunarbhava (bhasma should not regain its metallic nature after strong heating with jiggery, Abrus precatorius linn., honey and ghee) and Niruttha (bhasma should not regain its metallic nature after strong heating with silver). It was observed that Kasisa Bhasma of both methods possesses similar organoleptic as well as physico-chemical properties.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  4,382 229 -
Effect of pomegranate juice on dental plaque microorganisms (streptococci and lactobacilli)
Sowmya Kote, Sunder Kote, Lakshminarayan Nagesh
October-December 2011, 31(2):49-51
To study the effect of pomegranate juice on dental plaque microorganisms. A clinical trial was conducted on thirty healthy volunteers aged 25-30 years who visited Out Patient Department (OPD) of Bapuji Dental College and Hospital, Davangere during the month of October 2006. Before conducting the study, thorough oral prophylaxis was done and the subjects were asked to refrain from the oral hygiene procedures for 24 hrs. Dental plaque was collected from each subject, before and after rinsing 30ml of pomegranate juice without sugar. Plaque samples were cultured using Mitis Salivarius Agar and Rogosa SL Agar media. Wilcoxon's signed rank test was used for statistical analysis. Results showed that pomegranate rinse was effective against dental plaque microorganisms. There was a significant reduction in the number of colony forming units of streptococci (23%) and lactobacilli (46%). The ruby red seeds may be a possible alternative for the treatment of dental plaque bacteria.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  4,304 205 -
A comparative anti-inflammatory activity of raw and processed Kupeelu (Strychnos nuxvomica Linn.) seeds on albino rats
Swarnendu Mitra, Vijay Kumar, BK Ashok, RN Acharya, B Ravishankar
October-December 2011, 31(2):73-75
Seeds of Kupeelu (Strychnos nux-vomica Linn.), a known poisonous drug, is used extensively in various Ayurvedic formulations with great therapeutic significance. Ayurveda recommends the administration of Kupeelu only after passing through specific purificatory procedures in different media like cow's urine (Go mutra), cow's milk (Go dugdha), cow's ghee (Go ghrita), Kanji (thin gruel) etc. Strychnos nux vomica seeds are extensively advocated for nervous debility, paralysis, and weakness of limbs, sexual weakness, dyspepsia, and dysentery and in rheumatism where it can be assumed that besides other properties, Kupeelu may have some sort of anti-inflammatory activity too. In the present study, the powder of raw and processed Kupeelu seeds (processed / purified with Kanji i.e sour gruel) as test drugs were assessed for anti-inflammatory activity by employing Carrageenan and Formaldehyde induced hind paw oedema in Wistar strain albino rats at a dose of 22.5 mg/kg body weight orally. This study reveals that both raw and purified Kupeelu showed presence of highly significant anti-inflammatory activity against formaldehyde induced hind paw oedema, but did not have similar activity against Carrageenan induced hind paw oedema.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  4,139 185 -
Physicochemical characterization of an Iron based Indian traditional medicine: Mandura Bhasma
Sachin B Mulik, CB Jha
October-December 2011, 31(2):52-57
Full text not available  [PDF]  [PubMed]
  3,984 211 -
Hepatoprotective activity of Gumma (Leucas cephalotes Spreng.) against Carbon tetrachloride induced hepatotoxicity in wistar rats.
G Sofi, Mohd Yasir Khan, MA Jafri
October-December 2011, 31(2):44-48
Full text not available  [PDF]  [PubMed]
  3,782 222 -
Whole system Research and Ayurveda
P Ram Manohar
October-December 2011, 31(2):37-37
Full text not available  [PDF]  [PubMed]
  3,785 219 -