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   2011| January-March  | Volume 30 | Issue 3  
    Online since November 16, 2011

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Biodeterioration in Emblica based Medicinal products and their Aflatoxin contamination
GP Choudhary
January-March 2011, 30(3):65-71
In the present investigation, Emblica officinalis Gaerth. Syn Phyllanthus emblica linn. has been selected on account of its large scale use in manufacture of indigenous drugs. Among the various fungal, species, Aspergillus flavus was the most dominant and frequent species in most of food stuffs studied. The total population of Aspergillus. flavus was recorded in range of 20.30 x 103 - 89.50 x 103 colonies/g in dried Aonla, 8.00 - 42.25 x 103 colonies/g in dried Aonla, 8.00 - 42.25 x 103 colonies/g Triphala, 1.25 x 103 - 19.83 x 103 colonies/g in hair oil and 1.20- 27.00 x 103 colonies/g in Aonla syrup. Minimum 26.66% percentage incidence of aflatoxin contamination was recorded in samples where the frequency of Aspergillus flavus was 91.50%.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Sedative Hypnotic Activity of Manahshila (Realgar) -An Experimental Evaluation
Naveena Kodlady, MS Doddamani, Y Vishwanath, BJ Patgiri
January-March 2011, 30(3):78-83
Manahshila (Realgar) is one of the three major Arsenicals used in Ayurvedic therapeutics since ages. It is indicated in skin, respiratory, ophthalmic and psychological disorders. It is mentioned to be the best among Rasayanas and a good aphrodisiac. As Manahshila is indicated in Unmada (Psychological disorder); wide use of Manahshila in the formulations mentioned for psychological disorders; some of those formulations are used in treatment of sleeplessness and Ardraka (Zingiber officinale0 Roscoe) which is a commonly used Shodhana reagent of Manahshila is reported to be sedative, the potential sedative hypnotic activity is inferred and an experimental study was carried out to evaluate the sedative hypnotic activity of Manahshila. Effect of Ardraka Shodhita Manahshila (ASM) on the spontaneous motor activity of albino rats in actophotometer and on diazepam induced sleeping time was evaluated. There was a statistically significant reduction in the spontaneous motor activity (P<0.001) in the ASM treated Manahshila and there was early onset and hypnotic potentiation in the diazepam induced sleep in rats (P<0.01).
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  2,773 327 -
Effect of Taleeq (Leech Therapy) in Dawali (Varicose Veins)
Zar Nigar, Md. Anwar Alam
January-March 2011, 30(3):84-91
Dawali (varicose vein) is first described in Ebers Papyrus over 3500 years ago. Dawali is a disease in which veins of legs and feet become dilated, tortuous, and greenish in colour due to excess accumulation of blood which is derived from saudavi madda & balgham ghaleez. The aetiology of varicose veins is still incompletely under stood, despite the fact that it is a very common disease affecting all ages from teenagers to elderly people. The complication of varicose veins like venous eczema, venous pigmentation, lipodermatosclerosis, superficial thrombophlebitis, venous ulceration, etc impair health related quality of life significantly. The objective of the study is to evaluate the efficacy of Taleeq in Dawali and to provide safe & cost effective alternative treatment. Randomized controlled clinical open trial was conducted in regimenal unit of NIUM Hospital. 50 patients were divided into 2 groups, 30 in test & 20 in control group. Test group was treated with Taleeq on alternate day & control group was treated with grade 2 compression stockings & limb elevation for 2 months. Response was measured by assessment of pain / leg discomfort, limb girth at calf, ankle, and feet, pigmentation area & colour on every 15th day. Hb% was assessed on every 15th day to check anaemia. Effect on anatomy of vein was assessed by colour flow Doppler USG. Test group showed significant reduction in pain, limb girth, pigmentation, number of perforators. Control group showed significant reduction in pain & limb girth, but there was no improvement on pigmentation. Both groups do not show significant improvement on SFJ & SPJ incompetency. Test group has major effects in improvement of all parameters. Study stresses that leech therapy should be administered in combination with compression stockings & other effective treatment modalities like weight normalization for obese patients, physical therapy, dietary modification etc for optimal results.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
  2,765 259 -
Prevention of acetaminophen induced hepatorenal damage in mice with rhizomes of Glycyrrhiza glabra A histophysiological study
Anjali Sharma, HS Rathore
January-March 2011, 30(3):72-77
Protective role of Gycyrrhiza glabra rhizomes (roots) at three dose levels (100, 75, & 50 mg/kg/bw) against sublethaldose (300 mg/kg/bw) of acetaminophen (paracetamol) induced hepatorenal damage has been assessed in mice. Parameters of study were glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), billirubin, alkaline phosphatase (ALP) as liver function tests, creatinine and urea as kidney function tests and histology for pathology. G.glabra could antagonize acetaminophen induced both,hepato and nephrotoxicity in dose dependent manner. No protection provided by a single dose of G.glabra (1.5 gm/kg/bw) against lethal dose of acetaminophen (1gm/kg/bw). Probable protective role is discussed.
[ABSTRACT]   Full text not available  [PDF]  [PubMed]
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Ayurveda poised for change, So is the 'Ancient Science of Life'
Sujith Eranezhath
January-March 2011, 30(3):63-64
Full text not available  [PDF]  [PubMed]
  2,163 258 -
The History of Hindu Chemistry' is not a lost legacy
K. L. Virupaksha Gupta, Pallavi Gupta, Bishwajyot Patagiri
January-March 2011, 30(3):92-93
Full text not available  [PDF]  [PubMed]
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