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   2004| October-December  | Volume 24 | Issue 2  
    Online since November 11, 2011

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Synthesis and valuation of mannich bases of certain novel nitro hydroxy 1, 2 pyrazolines
K Krishnakumar, AR Bhat, K Umaa, AK Chandrasekharan
October-December 2004, 24(2):103-108
A study was conducted to synthesise and evaluate the anti-inflammatory and anti-microbial activities of mannich bases from 1, 2 - hydroxy pyrazolines. For this, vanillin was reacted with substituted acetophenones and different vanillinyl chalcones were obtained which when coupled with phenyl hydrazine, produced hudroxy 1, 2 - pyrazolines. The hydroxyl pyrazolines were reacted with sulpha drugs and other compounds of biological interest containing free amino group in the presence of formaldehyde when mannich bases of 1, 2- hydroxyl pyrazolines were obtained. The compounds were characterized by elemental analysis, Ultra Violet (UV), Infra Red (IR) and Nuclear Magnetic Resonance (NMR) studies. All the newly synthesized compounds have been screened for Anti-inflammatory and Anti-microbial activity. Out of six compounds, para nitro hydroxy pyrazolines of sulphadiazine mannich base (A), nitrohydroxy pyrazoline of sulphacetamide (B) substituted nitro hydroxyl pyrazoline of amino anti-pyrine mannich (F) exhibited significant or oedema in habiting oedem activity. Out of six compounds, para nitro hydroxyl pyrazoline of sulphadiazine mannich base (A) also exhibited anti-microbial activity.
[ABSTRACT]   Full text not available  [PDF]
  779 84 -
Phytochemical and Antimicrobial studies of extracts of Solanum xanthocarpum
R Udayakumar, K Velmurugan, Raghu Ram Krishna
October-December 2004, 24(2):83-87
Antibacterial activity of various parts (stem, leaf and fruits) of solvent extracts (Petroleum ether, alcohol and acetone) of Solanum xanthocarpum against Escherichia coil, Klebsiella of Solanum xanthocarpum showed high sensitivity to Escherichia coil & less sensitivity and resistance to Bacillus cereus. In control, no inhibitory zone was observed.
[ABSTRACT]   Full text not available  [PDF]
  764 90 -
Studies on some pharmacognostic profiles of Swietenia macrophylla. King
K Arumugasamy, KV Latha, NH Sathish kumar
October-December 2004, 24(2):97-102
The aerial parts and seeds of Swietenia macrophylla King (Meliaceae)  are used in exotic medicine systems. In the present study, a preliminary phytochemical and few pharmacological profiles were under taken. The physical constans, extractive and ash values were examined. The presence of secondary metabolites in the aerial parts and seeds showed that Swietenia macrophylla is a good source of active principles. TLC studies were done by treating dry treating dry powder of Swietenia macrophylla with various acids, iodine and ferric chloride solution and UV and Visible light.
[ABSTRACT]   Full text not available  [PDF]
  740 62 -
Preliminary phytochemical studies on bark of Commiphora berryi (Arn) Engllor
NL Gowrishankar, K Chandrasekaran, R Manavalan, D Venkappayya
October-December 2004, 24(2):88-91
Commiphora berryi (Arn) Englor (Burseraceae)  is a well known plant in Tamil nadu, India. It is used in several parts of the state for various medicinal properties. The present work summarizes preliminary phyto chemical study of bark of this plant.
[ABSTRACT]   Full text not available  [PDF]
  693 57 -
Mineral and biochemical analysis of various parts of Cissus quadrangularis Linn
R Udayakumar, M Sundaran, Raghuram Krishna
October-December 2004, 24(2):79-82
Ash, minerals and biochemical contents were determined in various parts of root, stem and leaf of Cissus quadrangularis. The maximum ash content was observed in the root. The maximum concentration of carbohydrate and protein in the root and phosphorus, iron, calcium and lipids in the stem were observed.
[ABSTRACT]   Full text not available  [PDF]
  669 64 -
Evaluation of activity of a Herbal formulation Pentapala 04 on the lung lipids against ova albumin and aluminium hydroxide induced lung damage in rats.
D Srinivasarao, Indira A Jayraaj
October-December 2004, 24(2):68-72
The aqueous extract was found to be more effective on the surfactant system of lung against ova albumin and aluminium hydroxide induced lung damage in albino wistar rats. The rats were divided into 3groups of four animals each, namely group I, II and III which served as control, toxic and post treatment groups respectively. Our results showed increased Lung Body-Weight Index (LBI) and decreased lung lipid content in the toxic group of animals. But the levels of lipid content and Lung Body-Weight Index were restored in post-treated group of animals, which might be due to the protective activity of "Pentapala-04".
[ABSTRACT]   Full text not available  [PDF]
  680 51 -
Studies of pharmacognostical profiles of Dansonia digitata linn.
T Vijayakirubha, D Ramprasath, K Karunambigai, D Nagavalli, S Hemalatha
October-December 2004, 24(2):60-64
The macroscopic characters of the whole plant, physical constant values, extractive values, preliminary phyto-chemical tests, fluorescence characters under ultra-violet light after treatment with different reagents of the powdered leaves form the tree of Adansonia digitata linn., [Bombacaceae] were studied to fix some pharmacognostical parameters. Preliminary phytochemical screening on the methanolic extract of the plant was also performed. These studies will help in identification of this plant for further research.
[ABSTRACT]   Full text not available  [PDF]
  658 71 -
Hypocholesterolaemic effect of Spirulina and Liv-52 in lead induced toxicity in Albino rats
K Jeyaprakash, P Chinnaswamy
October-December 2004, 24(2):73-78
Effect of spirulina and Liv-52 on lead induced hypercholesteroleamia in albino rats was studied. Oral administration of lead acetate(10mg/kg body weight/day) for 30 days resulted in a significant increase(P<0.01) in the level of serum total cholesterol, triglycerides, LDL Cholesterol and a significant decreases in the level of serum HDL cholesterol, when compared to normal and control group of albino rats. Administration of either Liv-52 alone or in combination with spirulina produced a well pronounced protective effect against lead induced hypercholesteroleamia in rats. Although administration of spirulina alone caused an appreciable protective effect in lead toxicated tats, further study is needed with increased doses to evaluate its optimal effect.
[ABSTRACT]   Full text not available  [PDF]
  673 51 -
Studies on pharmcognostical features of Zizyphus mauritiana Linn. Root (family : rhamnaceae)
R Mazumder, A Mazumber, S Bhattacjarya, Anju Singh, Priyanka Kapoor
October-December 2004, 24(2):92-96
Description of the root of the plant, Zizyphus mauritiana Linn. the microscopical characters of the powdered root, its behavior on treatment with different chemical reagents, and the fluorescence character under ultraviolet light after treatment were studied to fix some pharmacognostical parameters. Preliminary phytochemical screening on the various extracts of the root of the plant was also performed. These studies were carried out to identify this plant for further research work.
[ABSTRACT]   Full text not available  [PDF]
  664 49 -
Anti-inflammatory activity of cassia Aauriculata
S Manogaran, N Sulochana
October-December 2004, 24(2):65-67
Cassia auriculata is widely distributed even in poor soil in Sri Lanka, India, Burma and cultivated in tropics. Based on Physical and Chemical methods, the flower of C. auriculata was found to contain a flavonol glycoside 5-O-methylquercetin 7-O-glucoside. The 50% acetone extract of the flower of C. auriculata showed marked anti-inflammatory activity (56%) in carrageenin induced oedema in rats.
[ABSTRACT]   Full text not available  [PDF]
  647 50 -