Purpose : Obesity, the state of excessive adipose tissue, with increased morbidity, mortality from numerous diseases nearly in a pandemic stage; necessitates urgent search for safe, effective anti-obesity medications, as extant modern drugs have significant major adverse effects. Charaka elaborated very lucidly qualitative signs & symptoms of obesity (Sutrasthan A21). Gorakhmundi (Sphaeranthus indicus), a widely available seasonal wild herb, called Som-Sum-Veerya (Sushruta), Palankash (weathers fat away; Shaligram), Mundi (beheads diseases), anti-obesity effects mentioned in seven Nighantu(s); thus holds promise. This study evaluates its anti-obesity efficacy using single-blind, placebo-controlled design. Method: Forty persons (age 25-50 yrs), 20 each in study and control groups, with weight >10kg excess than LIC actuarial mean normal, evaluated at baseline using BMI, Waist/Hip Ratio, skin-fold thickness at Biceps, Triceps, Sub-scapular & Supra-iliac sites and also 23 qualitative criteria collated from Ayurveda's Classical Texts; were administered for 90 days at 2gm/day dose either Gorakhmundi Panchang-Choorna or Spinach Choorna respectively and reassessed monthly. Anthropometric measurements analysed using descriptive statistics & paired t test. Qualitative criteria- descriptive statistics. Result : At 90 days, Study Group shows -->5% weight reduction in 45%, 3-5% in 45%, 0.334/week or 1.34/month, Highly Significant- weight reduction, p<0.001, - Improvement in- BMI, p<0.001; W/H Ratio, p<0.001; -- Skin-fold Triceps, Subscapular, Suprailiac, p<0.001, (Biceps p<0.05), Qualitative features viz. Body Mal-odor, Hyper-sweating, heaviness, slackness, lack of swiftness, laziness, exercise intolerance, deep breathing discomfort, excessive thirst showed considerable improvement in majority persons showing these at baseline. Conclusion: Study confirms Gorakhmundi's significant anti-obesity efficacy, using single-blind placebo-control design and modest sample.

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Purpose: XRPD is an analytical technique for phase identification of materials. It determines the difference in the phase presentation as the process goes on progressing and changing. This technique was used in analysis of Samanya Shodhit, Samanya Shodhanottar Vishesh Shodhit and Vishesh Shodhit Tamra. Method: Samanya Shodhana and Vishesh Shodhana of Tamra was performed as described in RasaTarangini. (Tarang15). XRPD was done in PANalytical X'Pert PRO Diffractometer with secondary beam graphite monochromator selecting the Cu anode material. Four samples were prepared and analysed viz. Sample a - Ashodhit Tamra, Sample B -Samanya Shodhit Tamra, Sample C - Samanya Shodhanottara Vishesh Shodhit Tamra, Sample D - Vishesh Shodhit Tamra. Result: The XRPD of all the samples of Shodhita Tamra showed presence of copper and copper oxides in them. However, the peak positions and intensities were varying. Some new unidentifiable peaks were noticed. In all the samples, Cu was present in major or minor phase. Only Sample B showed presence of both CuO and Cu2O in it. Other Shodhit samples only contained Cu2O and Cu. Conclusion: Presence of CuO in only Samany Shodhit Tamra suggested its larger particle size. As, it was subjected to Vishesh Shodhana, it got converted to thermodynamically more stable Cu2O and lesser particle size. Though Sample C & D had copper oxide in major phases, they exhibited different XRPD pattern. This may indicate multiple crystal forms or polymorphism of copper compounds. Thus, XRPD is a crucial analytical tool to show that the structural and chemical transformation of metal into metal compounds started from the step of Shodhana itself. Furthermore, presences of metallic copper in all the samples denoted their partial conversion and evident need of Marana.

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Purpose: Cyclophosphamide (CP) causes stunting in size and loss of body weight of the pups when injected intra-peritoneal (10 mg/kg) to pregnant mice on day 11 of gestation. Due to anti-anaemic properties and nutritional values, Drakshavaleha has been used as a Naimittika Rasayana (promoter of specific vitality in specific disease) by some of the Ayurvedic physicians in Rajasthan to a woman during her pregnancy expecting a good health of both mother and her offspring. The objective of the study was to investigate the protective effect of Drakshavaleha against CP induced growth retardation in mice pups in the terms of body weight and CR (crown-rump) length. Method: Group I (Control): Pregnant mice (n=10) received 0.2 ml of vehicle (distilled water) intra-peritoneal on day 11 of pregnancy. Group II (Drakshavaleha): Pregnant mice (n=10) received Drakshavaleha (16g/kg) orally from day '0' to day '18' of pregnancy. Group III (CP): Pregnant mice (n=10) received Cyclophosphamide (10mg/kg) intra-peritoneal on day 11 of pregnancy. Group IV (CP + Drakshavaleha): Pregnant mice (n=10) received CP (10mg/kg) intra-peritoneal on day 11 under cover of Drakshavaleha (16 g/kg) orally from day '0 to day 18' of pregnancy. Result : Drakshavaleha (alone) increases the size and weight of the pups when given to mother mice during gestation period and the difference between the two groups (Group III and Group IV) is statistically significant (p<0.001). Conclusion: In the present context Drakshavaleha can be conceived to be a Naimittika Rasayana to a woman during her pregnancy to obtain a healthy progeny.

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Purpose: Vertebral disc lesion i.e. spondylosis (Cervical / Thoracic /Lumbar) and PID affects nearly 80% of population. It is the most common cause of job related disability leading to missed work and second most common neurological ailment. As per the modern management is concerned, there is no established treatment for it, except surgical intervention, which cause complications and side effects.The present study has focus on the effectiveness of panchkarma combined with shamana therapies. Method: The study was conducted in 100 clinically diagnosed patients of vertebral disc lesions. These patients were randomly selected and divided in to two groups. I. Patients having cervical lesion were kept on Panchkarma (Udvartan and Valukasveda Snehan, Swedan, Vamankarm, Tiktksheer Basti, Greevabasti, Nasyakarma.) II. Patients having lumbar lesions ware kept on (Udvartan and Valukasveda Snehan, Swedan, Virechankarm, Tiktaksheer basti, Katibasti, Nasyakarma.)After that both groups were kept on oral drugs such as Tab. Arogyavardhini-250mg BID, and Tab. Panchtiktakgrithguggul-250mg BID. With local abhyanga and nadisveda for 1 month. Result: The patient was assessed after completion of treatment and follow up was done. The incidence of presenting features was worked out and the severities of the symptom were recorded statistically in each case and data were analysed. Both groups showed improvement in signs and symptoms significantly. Conclusion: Vertebral disc lesions are progressive degenerative conditions in which vata at its own Ashaya (Asthi-Sandhi) gets provoked and as it belongs to MadhyamRogamarga treatment becomes challenging. This attempt possibly finds solutions which can delay or even prevent surgical intervenation as sandhis are sites of Marma. It is an effective, simple, safe, treatment modality for vertebral disc lesion.

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Purpose: Modern medicine is rapidly developing medications that provide instant relief from symptoms, but the hazards of beta agonists, toxicity of xanthenes and complications of corticosteroids prompt the search for alternative modalities in the management of bronchial asthma. The present work evaluates easily available, inexpensive and non-controversial herbal drugs as well as Pranayama in the management of bronchial asthma. Method: For this clinical study 60 patients have been divided into 3 groups. 1st Group was treated with trial drug and 2nd Group with standard drug. The 3rd Group was treated with trial drug and Pranayama. All the groups have equal number of patients -i.e. 20 each.The short-listed patients were diagnosed on the basis of a detailed questionnaire including the history, clinical examination as well as laboratory investigations. The diagnosis was further confirmed using spirometer. Diagnosis has been made according to bronchial reversibility test i.e. 15% increase in FEV1 after 15 minutes of two puffs of a adrenergic agonist. Subjective as well as objective parameters were adopted for assessing the response of trial drugs graded in to 0, 1, 2, and 3. Patients were advised to practice the anulom vilom pranayama BD, 10m. Result: Results were discussed on basis of % improvement, standard deviation, p value, p value for eg. N BT, AT, % imp, S.D., t, p, result, - Group III, 18, 2.05, 1.33, 35.12, 0.46, 6.65< 0.001 HS Conclusion: Group I & III shows significant improvement in clinical symptoms whereas Group III patients also showed marked improvement in PULMONARY FUNCTION TESTS (FEV1, FVC, PEFR). It was observed that anulom vilom pranayama has a definite additive effect with standard drug therapy in the treatment of Tamak swasa (bronchial asthma) as shown by the subjective and objective assessment.

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Purpose: Ayurveda describes Agni dushti to be the root cause of all diseases in humans. The diagnosis of these diseases is mainly based on clinical features supported by clinical examination and ancillary investigations. For this several methods have been described in Ayurvedic texts, which can be broadly classified into Roga and Rogi pariksha. These examinations are mainly based on clinical observations. Examination based on laboratory investigations is rather a late development pertaining to medieval period. Mutra Pariksha and Purisha Pariksha were the main laboratory investigative tools in the past. Jalnimanjjan purisha pariksha, an old method of stool examination has been described in number of Ayurvedic texts of medieval period which was very popular in those times but now its use has become obsolete. Hence, it is important as a first step to revive this technique to standardize it. This study aimed at standardizing this technique of Jalnimanjjan purisha pariksha and observing for the normal variable range in 30 apparently healthy volunteers along with their Agni assessment and routine as well as microscopic examination of stool. Method: A water sample was standardised first to be used as media for nimanjjan and then different amount of stools were dropped. The height of dropping etc was standardized in random samples. After standardisation, test was performed in 30 normal healthy volunteers and the various observations were recorded. Result: Significant results were found in correlation with the various textual descriptions of Ayurveda regarding purisha and Agni pariksha. Conclusion: Similar study on a larger number of volunteers will further validate the data and can be used in future for the assessment of Agni by purisha pariksha.

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Bhasmas are unique Ayurvedic metallic preparations with herbal juices/fruits widely used for treatment of a variety of chronic ailments. The bhasmas are products of classical alchemy, organo-metallic compounds of certain metals and gems in a very fine powdered form, mostly oxides, made in elaborate calcination processes perfected several centuries ago. Recent articles pertaining the alarming level of heavy metals, especially Pb, Hg, and As in Ayurvedic formulations have created a lot of controversy regarding the safety and efficacy of Ayurvedic formulations. It has been reported that lead, mercury, and arsenic have been detected in a substantial proportion of Indian-manufactured traditional Ayurvedic medicines. An attempt was made to study heavy metal poisoning with special reference to current research on toxicity of Naga bhasma. This study clearly shows that Naga bhasma is not just lead, it's a compound form predominantly crystalline i.e. mixture of PbO Pb3O4. XRD data revealed OH and (CO3) 2 group which contain some other essential elements in minute quantity and didn't have any toxic effect at LD50 which was 160 times higher to that of Therapeutic Equivalent Dose (TED) (12.5 mg/kg) in acute toxicity study.

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Purpose: To convert natural origin drug into targeted drug delivery system, optimising the dosage form (microspheres containing natural drug) to procure the best dosage form of prepration and to aim a targeted site (liver) so as the maximum amount of drug can reach the targeted site with the outmost motto to achieve the maximum therapeutic efeect at desired site (liver) and the desired aim to avoid the adverse reaction of synthetic drugs system. Method: Method employed is that procurement of drug, followed by extracting its particular compound, evaluation and characterisation, then proceeds to convert into targeted drug delivery system, followed by optimization of dosage form, then proceeds to pharmacological process of liver targetting. Result: By loading natural drug into optimised targeted drug delivery system, a remarkable result has been achieved by analysing SGOT (Serum glutamic oxaloacetic transaminase), SGPT (Serum glutamic pyruvic transaminase) and Histopathology profile. Conclusion: The outmost conclusion is that the natural origin drug when convert into targeted drug delivery shows significant and remarkable hepatoprotective activity which opens the new era of treating many hepatic diseases with the foremost aim of avoiding adverse effect of drugs, thus ayurveda proving its utility again in this moder age of medicinal world.

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Purpose: It is a known fact that Iron is nephrotoxic, causing various urinary diseases which when untreated results in fatal condition like renal failure. But Ayurveda, after subjecting to various Samskaras (processings), has used Loha (Iron) in bhasma (calx) form in numerous formulations to treat urinary diseases. These diagonally opposite perceptions form the very base of the present work where in Varunadi loha, a formulation containing Loha bhasma, described in Bhaishjyaratnavali was studied for its pharmacological action using Sprague Dawley rats as an experimental model. The study was carried out at National Toxicology Center (NTC), Pune (IAEC Clearance no.-RP 128-181211). Method: The acute toxicity study showed Varunadi loha to be safe at the maximum dose of 2000mg/kg. Gentamycin induced nephrotoxicity model was used for the study. In the pilot study of 15 days, it was noted that rats in the prophylactic group died at the end of 8th day. So in the main study, prophylactic group was omitted. The main study was carried out with 24 rats which were equally divided in 4 groups as normal control, disease control, curative and safety. Result: In control group the results were not significant as the rats were non diseased and kept on normal diet. In disease control group, results were highly significant in serum creatinine and serum urea levels as the levels were raised. In curative group results were significant in serum levels as there was moderate decrease in serum creatinine and serum urea levels after the treatment with Varunadi loha. In the safety group the results were non-significant indicating the drug showed no adverse reactions at therapeutic dose. Conclusion: Significant decrease in serum creatinine and serum urea in curative group was suggestive that the drug Varunadi loha was delivering its best to improve the lost kidney function.

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Purpose: Quality aspect and variability observed in physico-chemical characteristics and mineral content of ayurvedic herbomineral formulations from indian market w.r.t brihat vat chintamani rasa. Method : Each of the selected herbomineral formulation was thoroughly investigated for the variation in packaging material, label information, analytical parameters like moisture, pH, ash and mineral content such as Iron, Mercury, Gold, Copper and Zinc which play a crucial role in increasing the bioavailability of the drug to the cell. Result : Brand A has maximum iron content of about 8.93 % w/w; Brand B has iron content of about 8.37 % w/w; Brand C has iron content of about 6.86 % w/w and Brand D has low iron content of about 3.54 % w/w. Similar is the case with other parameters. Conclusion: There are variations in quality of the drug from one brand to other. This has to be addressed through development of adequate standards for drug content, process control, monitoring misuse of label requirements. A vast majority of our country population is using indigenous herbomineral drugs for treatment and cure. If we claim that these drugs relieve patients from pain and said indications, then manufacturing and marketing of ineffective medicines is a crime in disguise. It is therefore necessary that standardisation of Ayurvedic mineral medicines should be taken up as a priority programme.

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Purpose: Medicinal plants are highly valuable to human livelihood and the medicinal plant wealth of India is well recognised. Studies on possible effects of climate change on medicinal plants are particularly significant due to their value within traditional systems of medicine and as economically useful plants. There is evidence that climate change is causing noticeable effects on life cycles and distribution of the plant species. However, the effect of climate change on secondary metabolites in plants is not well understood. A need for research to improve our understanding of climatic effects on medicinal plants is stressed in the present article. An attempt is being made here to review the work so far done on this important issue with Indian perspective. Method: Reviews have been collected from different sources related to medicinal plants. Result: The impact of climate change with respect to medicinal plants has been discussed under the following heads. Effect of elevated CO2 on productivity and quality, Effect on threats to medicinal plants species, Adaptation measures for climate change and global warming, Mitigation measures to reduce emission of CO2/GHGs, Future strategies for research. Conclusion: The impact of climate change on medicinal plants both cultivated and wild is very significant. The need of the hour is to have a focused research approach specially on the accumulation of secondary metabolites of health significance. The research on medicinal plants with respect to climate change is very sporadic and insignificant in comparison with other commercial crops. It is the high time that, these group of plants should not be left as they are potential sources of bio-molecules and neutraceuticles.

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Purpose: Due to growing nuclear nature of urban families, pets like dogs are becoming popular companions. A skin disorder is common in dogs and is a concern for human coming in contact. Natural remedies need to be assessed for long term safety of dogs and humans. There is evidence that in dogs, Neem oil can help with fleas, ticks, intestinal parasites and mange mites. According to Ayurvedic medicine. Neem oil improves the clinical signs of skin disorders. To study its action in canines, further work was required on the efficacy of Neem oil in the treatment of canine atopy. Method: Effect of a preparation of Neem oil on canine atopy was assessed in a open, placebo-controlled trial. Privately owned dogs were used and the clinical signs of atopic dermatitis were evaluated by the owners. For a period of 3 weeks, the dogs daily received application with Neem oil (n = 9) or vehicle (n = 8). During the trial, all dogs were cleaned with the use of regular bathing shampoo in order to maintain hygiene. To assess the severity of atopic dermatitis, the clinical signs scored were itching, redness, scaling, thickening and stripping of skin. The severity of the signs of atopic dermatitis was scored by the owners by marking with a cross a 10-cm, horizontal line. Result: For all five clinical signs, the group-mean improvement, expressed as change of severity score over time, was greater in the test group than in the controls. Within each group, the changes for the five clinical signs were added up to arrive at an overall index of improvement of atopic dermatitis. The extra improvement caused by the application of Neem oil was significant. Conclusion: Neem oil can be considered as effective and is beneficial for dogs with atopic dermatitis.

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Purpose: Ayurveda is one of the most ancient systems of medical health care. The basic principles, diagnosis of the diseases and their treatment are based on individual prakriti (constitutional type). Ayurveda further classifies the prakriti of an individual on the basis of a set of psychosomatic attributes of personality, depending on whether this individual belongs to Vata, Pitta, or Kapha prakriti, or any combination of them (Patwardhan et al., 2005). The appropriate prakriti assessment is done by several means including questionnaires (Rastogi, 2012; Shilpa and Venkatesha-Murthy, 2011). We aimed to obtain experimental evidence correlating Ayurveda based tridosha-prakriti with western constitutional psychology somatotypes (Rizzo-Sierra, 2011). Method : We employed our Tridosha-prakriti questionnaire (Ramakrishna and Nagendra, 2012), and compared its results with a set of body composition parameters: Height, body weight, body mass index (BMI), muscle mass, fat mass, and fat percentage in normal healthy volunteers (25 males and 25 females, mean age was 26 (΁ 4) and 25 (΁ 6) years respectively). Moreover, two-tailed Pearson™s correlations were investigated to match the extreme prakriti types with the western constitutional psychology somatotypes, through the mentioned body composition measures. Result: Significant negative correlations were observed between the percentage of Vata attributes as per the questionnaire in the individuals and their BMI, body weight and fat mass respectively (p<0.05). Similarly, there was a significant positive correlation between the percentage of Pitta attributes with the height, body weight, and muscle mass respectively. Also, a significant positive correlation was observed between the percentage of Kapha attributes with fat mass and fat percentage, along with a negative correlation with height. Conclusion: We provide evidence-linking Ayurveda to modern constitutional psychology. In this way, a concept such as prakriti is suggested to lie behind the body mass composition of an individual, and deserves attention within the scientific community.

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Purpose: Coronary Artery Disease is forecasted to be the most common cause of death globally, by 2020. The only standard care of treatment (SCT) for CAD i.e. CABG/PTCA is invasive and expensive. There is no established medical management for reversion of CAD except medical maintenance of CAD. We propose cost effective herbo-mineral preparation with the complete protocol, expected to cost US $ 500 against the cost of SCT: US 2000 +; which will avoid CABG/PTCA and the recurrence of CAD in post CABG/PTCA patients. The therapy would be beneficial for the contraindicated conditions of CABG/PTCA. Method: This is an open, single arm, prospective study with sample size of 20 patients in pilot study (2years) and 200 in the final study (5yrs). Established CAD patients in the age group of 15-60, having LVEF >30% are recruited. The patient having Left Main Disease, proximal LAD disease >66%, other cardiac dysfunctions like MR, Left Ventricular Aneurism, VSD, LVESV> 60ml are excluded. Investigations include CAG (Day 0 and after 12 months), 2 D Echo, TMT,(BSL/HbA1c in stable DM2) and RFT/LFT every 4 months. Result : Interim analysis reveals major findings including, 1) significant reduction in CA blockage with imrovement in TMT, 2DEcho and QOL, 2) statistical data of Dosha predominance in CAD, male to female ratio.3) Ayurvedic etiologies of CAD with prevalence of stress factor in majority of cases, 4) safety data of drugs after prolong administration of Ayurvedic Conclusion: Confirmation of reversion of CAD with imrpovement in QOL, No safety issue (though protocol includes herbomineral preparations), Challenges like recruitment, follow up, salient observations will be discussed in details, It is not a single drug or herbomineral but the complete Ayurvedic protocol proves effective in reversion of Tridoshtmaka disease like CAD.

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Purpose: In present era, Artavkshaya (oligomenorrhoea) is becoming a problem due to life style changes and excess physical and mental stress. All menstrual disorders are due to vitiation of apana vayu. Krishnabola (Aloe barbendis) is mentioned in Ayurvedic texts for the treatment of artavakshaya due to its artavjanak (emmenagogue) property. The aim of the study was to access the efficacy of Krishnabola in patients who were suffering from artavkshaya (Scanty menses, increased inter menstrual period, and decreased duration of menstruation) and on the functions of apanvayu. Method: The artavjanak (emmenagogue) activity of the Krishnabola (Aloe Barbadensis) was studied in women who were suffering from Artavkshaya (Scanty menses, increased inter menstrual period, and decreased duration of menstruation). Clinical trial was carried out at Government Ayurved College, Nanded (M.S.) on 80 patients of aartavkshaya in two groups. In experimental group 100 mg of krishnabola powder was given orally with lukewarm water before meal twice a day to 40 patients and in control group placebo (Indian arrow root powder) was administered for three consecutive menstrual cycles. Then the effect on functions of apanvayu and duration of menstrual period, inter menstrual cycle period, amount of menstrual blood were observed .The data was analysed by statistical z-test. Charaka Samhita, Sushruta Samhita, Ashtanga Hridaya, Bhavprakash, Indian Materia Medica, Text book of Gynaecology were consulted for relevant information. Result: 1) Krishnabola increased the amount of menstrual blood (72%), period of menstruation and decreased inter menstrual period (69 %) as well as incidences of dysmenorrhoea (66%). 2) Krishnabola improved the functions of apanvayu. Conclusion: The collected data points to the role of krishnabola (Aloe Barbadensis) in the management of artavkshaya. Being emmenagogue, krishnabola increased amount of menstrual blood, duration of menstruation and decreased inter menstrual period significantly. Statistical z test showed significant results.

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Purpose: Polydactyly is a most common congenital hand defect in which the hand has one or more extra fingers, commonly seen post axial i.e. on the small finger side, affecting about one out of every 1,000 babies. It is usually treated by surgically removing the extra finger typically, when the child is between 1 and 2 years old. Prognosis after removal of extra digit is good, though not devoid of complications like scar formation, instability and late deformity which may need additional reconstructive surgery to recover full function and improve the hand's appearance. The evidence of polydactyly is linked with superstitions related with divine phenomenon. Due to the myth and fear of complications, parents hesitate or are reluctant to opt for surgery. Method: In this study, Ksharsutra, an Ayurvedic medicated thread coated with herbal alkaline drugs having simultaneous cutting and healing property was used by free ligation technique to remove extra finger in a child, whose parents were not willing to undergo surgery. This was an observational single case design without controlled group. Result: After Ksharsutra ligation, the extra finger started necrosing within 24 hours. The finger turned bluish to black in next 3 days with minimal pain at the site of ligation and finally sloughed out in just nine days with minimal scar formation. Conclusion: Ksahrsutra Ligation showed excellent result in postaxial polydactyly. The results are encouraging enough to warrant more studies to establish and promote this unique para surgical procedure i.e. Ksharsutra in the management of postaxial Polydactyly.

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Purpose: Insomnia is a sleeping disorder characterised by persistent difficulty in falling asleep or staying asleep despite the opportunity. It is one of the burning problems all over the world. Statistics shows that 20% - 40% adults encounter insomnia problems during a year time. Allopathic hypnotic drugs are useful for short term treatment in Insomnia which is due to acute stage. Long term uses of certain classes of sedatives cause physical dependence and withdrawal symptoms also have a number of side effects. In the present era, patient prefers readymade, cost effective, easily palatable drugs with fewer side effects for their health problems. For the present clinical trial, Parsikayavanyadi Capsule consisting of Parasikayavani, Jatamamsimoola, triturated with juice of Sankhpushpi and Kushmanda, was formulated to evaluate its efficacy in the management of insomnia Method: Total 32 patients of newly diagnosed case of insomnia who were randomly divided in to two groups. In Group P.V (Parasikayavanyadi group), 20 patients were administered 5 capsules of Pariskvayanadi Churna of 500 mg each with a cup of warm milk at bed time for one month. In Group P.C (Placebo group), 12 patients were given Starch Capsules of 500 mg each with same Anupana and duration. Assessment was done considering the overall improvement of insomnia according to Pittsburgh insomnia rating Scale, improvement of associated complains of insomnia, relieving of negative emotions, improving of positive emotions, relieving of level of anxiety according to Hamilton Anxiety Rating Scale and relieving of level of depression according to Hamilton Depression Rating scale before and after one month of treatment period. Result: parasikayavanyadi capsule provided significant effect in the management of insomnia. Conclusion: The study has revealed that parasikayavanyadi capsule provided significant effect in the management of insomnia in comparison to placebo.

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Purpose: Eclipta alba Linn. (Asteraceae) is used traditionally in Indian system of medicine as anti inflammatory, hepatoprotective, hypoglycemic, immunomodulator, in wound healing, and as a potent hair growth promoter. The study was aimed to evaluate the antisecretory and gastroprotective effects of 50% ethanol extract of Eclipta alba. Method: Eclipta alba extract (EAE) at 50, 100 and 200 mg/kg was administered orally, twice daily for 5 days to prevent from, cold restraint stress (CRS), and pylorus ligation (PL) induced ulcers. Antioxidant studies were performed in CRS induced ulcer model. Gastric wall mucus and secretion parameters like volume of gastric juice, acid output and pH were estimated in PL induced ulcer model. Ranitidine (50mg/kg, p.o.) was used as positive control for comparison. Result: A dose dependent and significant (p <0.05) reduction in lesion index was observed in ulcer-induced rats treated with EAE at various doses when compared with control group in both the models. Gastric wall mucus production was significantly (p<0.05) elevated in EAE treated rats. Significant attenuation in lipid peroxidation, superoxide dismutase activity was observed, whereas, catalase enzyme levels were elevated in EAE treated groups. Antisecretory activity of EAE was evidenced by significant reduction in gastric volume, acid output and increase in gastric pH when compared to their control values. The findings were further supported by histopathological examination of stomach in both EAE treated and control rats. Conclusion: The results of the present investigation suggest that ethanol extract of Eclipta alba possesses potent antisecretory and gastroprotective activity. The exact mechanism to be evaluated further but in preliminary observation it was thought to be mediated through free radical scavenging activity.

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Purpose: To achieve the goal of good rural health the need of incorporation of Ayurveda was realized and Ayurveda Gram Yojna was implemented in Govt. Ayurveda Dispensary of Chhattisgarh. Aims were to achieve good public health in rural area, maintain lifestyle according to Ayurvedic regimen, promote cultivation and use of medicinal plants, control and prevent endemic diseases, make national health program successful in those villages. Method: A comparative study was done before and after implementation of AGY from 2009 to 2012 in Govt. Ayurveda dispensary, Gorpar village. Data was collected from the available reports and the records at the Govt Ayurvedic dispensary regarding the operational mechanism and utilisation of the services and their benefits under the AGY. All the data collected were critically analysed and expressed in means. Result: In Gorpar village AGY was implemented since 2009. Increase in number of patients visiting the dispensary old 147 to 301, Female 1126 to 1745, male 1365 to 2091 before and after respectively. Health camps done 0 and 11 (no. of patients 1156), Yoga camps done 0 and 2, school health camps done 0 and 11 (no of students treated 825), Ayurveda awareness camp done 0 and 3, Plantation of medicinal plant in village 0 and 128, training program for Mitanin 0 and 3 before and after respectively. Before implementation of this yojna there were endemic disease like diarrhea but after implementation there was no any endemic reported. After this yojna dispensary took part in national program like family control program, malaria and T.B. control program, leprosy eradication program. Conclusion: Upgrowing trend shows that Ayurveda gram yojna is effective program for improvement of rural heath through Ayurveda. Beside few shortcomings at the quality, quantity and adequacy of the system strength of the services through it, it has a large and positive impact on the rural health.

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Purpose: Shoulder joint has greatest range of motion among all joints in body, and is of vital importance to daily activities. Frozen shoulder that causes pain and restricted movement of joint, puts huge amount of strain on patients in their most productive years of life. The etiology of frozen shoulder is unknown but diabetic patients may suffer more frequently. Till date no definite treatment is available for frozen shoulder. In Ayurved classics, Avbahuka occurring due to dhatukshayajanya vata prakopa has been told to be treated by different ways including Agnikarma. Hence study was designed to assess therapeutic outcome of Agnikarma in Avbahuka (frozen shoulder). Method: A male patient of 60 years having painful restricted movements of shoulder joint since 3 months was diagnosed as Avabahuka. He had already taken allopathic conservative treatment and intra-articular injection of corticosteroid but did not get relief. In this case, Agnikarma was done with Panchdhatu shalaka on supero- posterior and lateral aspect (including deltoid insertion area) of shoulder joint in two successive sittings at one week interval. Clinical assessment was done on 7th and 15th day of study by relief in pain by VAS score and changes in movement of shoulder in the form of angle. Result: The Visual Analog Scale (VAS) before treatment was 8 and it reduced to 4 on 7th day and then pain score was 2 on 15th day. The angle of flexion and elevation of arm before treatment was 950, after 7 day it was increased up to 1200 lastly on 15th day the angle was 1500. The angle of abduction and elevation before treatment was 800 then 1100 on 7th day and 1200 on 15th day after Agnikarma. Conclusion: This case study showed that Avbahuka can be treated with Agnikarma.

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Method: CRF was designed with the help of ayurvedic classical text and patients of mootrakrucchra vyadhi were selected for the study. Urine and blood samples were collected for routine tests of the urinary system. The relationship of those results with the related types of mootrakrucchra vyadhi were observed. Result: Out of 100 patients of mootrakruucchra, 72 were from different types of ashmari,i.e. vataj,pittaj and kaphaja ashmar,12 from shukraja mootrakrucchra,10 from pittaja and remaining from plain kaphaja mootrakrucchra. In urine examination, pittaj and pittashmarijanya mootracrucchra showed more RBCs, kaphaja mootrakrucchra showed pus cells, higher specific gravity and presence of proteins in urine. Level of serum urea and serum creatinine did not show specific correlation with any of type of mootrakrucchra vyadhi of ayurvedic concept. Conclusion: Mootracrucchra vyadhi shows the obstructive dysfunction in the passing of urine from urinary tract. The related abnormalities and related pathology reflected in the terms of signs and symptoms as per types of mootracrucchra. As serum urea and serum creatinine are related with the abnormality of process of formation of urine which is related with upper urinary tract i.e.kidney and its parts, levels of these blood investigations do not show any specific correlation with any of types of mootrakrucchra, it seems that samprapti of mootrakruccha is related lower urinary tract.

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Purpose: In an effort to develop crop ideotypes for multi-storey cropping under the conditions of eastern Uttar Pradesh, India, a few locally well-adapted chenopods (Chenopodium species) were examined for high yields and their compatibility with many other crops. A few genotypes were identified, selected and recommended as a sole crop as well as along with many other crops. The medicinal value of these chenopods in increasing haemoglobin content in anaemic patient was also evaluated. Method: Available chenopods were evaluated for yield and compatibility in a completely randomized design. About 200 grammes of fresh tender shoots were cooked and fed every day to an anaemic patient having his initial haemoglobin content at 5.2 units. Result: These chenopods produced 13125 to 22688 kgs/ha of edible grade biomass as a sole crop as well as in various crop combinations. The average land equivalent ratio for intercropping with Phaseolus vulgaris was 1.20 indicating 20 per cent yield advantage over sole cropping. These plants were also used as mulch, fuel-wood, walking sticks and live standards for pole type rajma and many other climber crops. After nine days feeding to the anaemic patient, the haemoglobin content increased from 5.2 to 10.0 units. Conclusion: High-density sowing/transplanting coupled with frequent uprooting/picking is trapping solar radiation very efficiently right from its early life stage. A concerted research effort would make it a successful industrial crop. These genotypes are high yielding, input responsive and amenable to scaling up for large scale cultivation. These chenopods are also amenable to the spirit of intensification in the sense that they are responding well to transplanting, spacing and canopy management. A temporally staggered sowing/transplanting, frequent picking/harvesting and high input and high density agriculture would generate a large amount of edible grade biomass that could be used as food, medicine, fodder and feed.

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Purpose: Maternal Ahara is an important modulator of maternal health and foetal growth. Various dietary regimens for pregnant women are described under Garbhini Paricharya, emphasising on real demand of the time for proper growth and development of foetus, for normal labour, for keeping good health of the mother and making free from postnatal complications of mother and child. Birth weight of newborn is strongest indicator of perinatal mortality. Pathya Ahara during pregnancy could decrease the incidence of LBW babies, improves survival of newborns and decreases perinatal mortality. Method: Pregnant women (100), registered in S.S.Hospital, BHU and delivered live born single babies were included and those with known medical illness, associated obstetric complications, unknown last menstrual period, cases of multiple pregnancy and congenital malformation were excluded. Pregnant women were subjected to detailed dietary profile to know the quality of food consumed during pregnancy and their newborns were subjected to anthropometric measurements to assess foetal outcome. Result: Out of 100 pregnant women 39 had taken Satvika- Rajasika ahara, 22 had Satvika-Tamsika ahara and 39 were taking Rajasika-Tamasika ahara. Most of the mothers taken Satvika-Rajasika ahara delivered fair or wheatish complexioned babies with higher birth weight and crown-heel length. Majority of women with low birth weight, and dark complexioned babies were taking Rajasika-Tamasika ahara. Significant association was observed between quality of maternal ahara and baby™s head circumference, chest circumference and mid-arm circumference. These measures were gradually less in babies of mothers taken Satvika-Tamasika and Rajasika-Tamasika Ahara. Conclusion: Food items mentioned in Garbhini Paricharya are mainly Satvika in nature. Satvika Ahara is well nourishing and balanced diet containing all essential nutrients like carbohydrates, fats, vegetable proteins, minerals and vitamins. By improving the quality of maternal Ahara, foetal outcome will be better in the form of increased birth weight and decreased perinatal mortality.

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Purpose: To prove whether Matravasti shows multiple effects on different systems in old people and to substantiate the effects of Matravasti and Rasayana on clinical basis in ageing. Method: Eighty two patients - Men of age group 50 - 80 years; Women aged above 45 years or who have attained Menopause and <75 years suffering from common problems of old age irrespective of sex, caste, religion etc. were registered for the study from the OPD of MCD Ayurvedic Dispensary, Krishna Nagar, Delhi and OPD and IPD of PG Dept. of Panchakarma, Madhav vilas hospital, Jaipur. Out of which, 16 patients dropped out did not complete treatment. Matravasti was administered for 21 times with Balashwagandha lakshadi (BAL) Taila on alternate days with a dosage 30 - 80 ml accordingly. After completion of 21 days of Matravasti, all the patients were reviewed for successive 6 months. All the cases were assessed by considering 15 different aspects reflecting the common problems of ageing like Activities of Daily Living (ADL), Instrumental Activities of Daily Living (IADL) etc., Result: The overall effect and maximum benefit observed was FAIR (25 % - 50 %) in 38 cases out of 66 patients. GOOD response (51 - 75 % response) in 26 cases and remaining 2 cases Best response (>75%). And the maximum benefit observed among all the cases is 81.8 % and the least effect was 25 %. Among all clinical parameters considered for the study maximum efficacy was found in sleep disturbances (67.5%) followed with gait balance deficit (56.25%), emotional status (55.1%), urinary incontinence (55%), Mobility (53.96 %), IADL (51.3%), ADL(50.8%), constipation (49.5%), cognitive status (48.78%), pain (48.14%), dyspnoea (47.25%), hearing impairment (42.5%), visual impairment (41.8%), dermatological manifestations (41.17%), and involuntary movements (22.2%). Conclusion: Matravasti is a multifaceted and highly effective therapeutic measure in the geriatric conditions.

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Purpose: A comparative clinical study was conducted on the management of Diabetic Retinopathy (DR) with Doorvadya Ghrita Tarpana and Mahavasadi kwatha internally. The main aim and objective of the study was to evaluate the efficacy of Doorvadya ghrita Tarpana and Mahavasadi kwatha internally, when used individually and as an adjuvant. Method: The patients were randomly divided in 3 groups with 15 patients in each group. Group A: Tarpana with Doorvadya Ghrita for 3 sittings, 5 days in each sitting, with a gap of 11 days after each sitting, total 48 days duration. Group B: Mahavasakadi Kwatha Pana with 50ml dose every day in the morning, empty stomach, for 48 days. Group C: Both Doorvadya Ghrita Tarpana and Mahavasakadi kwatha pana, for 48 days. Result: All the three groups have shown statistically significant results. Group B and C have shown better response as compared to Group A. Moreover Group B has shown slightly better response as compared to Group C. Conclusion: The study showed that microaneurysms, intra retinal haemorrhages, exudates are best managed by treatment with Group-B; where as blurred vision responded better to combine treatment of Group-C. Other parameters like neovascularization did not produce any significant result in any of the groups. Hence Ayurvedic management definitely prevents further progression of the Diabetic Retinopathy and its complications.

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Purpose: This study has been conducted on 50 apparently healthy elderly persons by treating them with Ashwagandhadi Lehya to assess the efficacy and safety of the drug on various health parameters. Method: 50 patients of age between 50 -75 years were registered from the O.P.D. of N.I.A., Jaipur in this study out of which total 42 patients completed treatment. Ashwagandhadi Lehya was given in the dose of 10 gm BD After meals with Luke warm milk for 84 days. Diet restrictions according to Pathya -Apathya were advised. Result : This formulation provided statistically highly significant relief in chief complaints like dizziness, constipation, abnormal sleep, loss of appetite, fatigue, generalized weakness, sense of well being and in mental aspect depression, physical and psychological health also.The drug was effective to improve Hb%, change in serum creatinine, unconjugated bilirubin, serum cholesterol and LDL levels significantly. Conclusion: A number of Medhya Rasayana Dravyas present in formulation have very good anti oxidant, anabolic, adaptogenic, anti stress and anti depressant property that improves the mental and physical health of the aged person.

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Purpose: To study anti-obesity activity of Ziziphus mauritiana Lam bark powder (ZMBP) on High Fat Diet (HFD) induced obesity in rats. Method: Obesity was induced in Wistar rats by feeding high fat diet (HFD) for 70 days. The obese rats were distributed in 4 groups (n=5). Group 1: Normal (lean) Control, Group 2: Obese Control, Group 3: Obese rats administered orally 250 mg/kg ZMBP daily, Group 4: Obese rats dosed with 500 mg/kg ZMBP daily, Group 5: Obese rats dosed with Standard Drug Sibutramine, 0.90 mg/kg. The rats were dosed orally daily for a period of 90 days. The animals were screened for induction of obesity by analysing obesity parameters such as Body weight, Anthropological Parameters, Serum Tryglycerides, Serum Cholesterol, Glucose tolerance test, Insulin resistance Test, DEXA analysis and MRI Scan. Result : At the end of 90 days treatment with ZMBP the obese rats showed 16.33 % reduction in body weight gain at 250 mg/kg and 17.38 % (P<0.05) reduction in body weight gain at 500 mg/kg when compared with the obese control group respectively. The standard drug Sibutramine showed 5.52% reduction in body weight gain when compared with the obese control group. The DEXA analysis at the end of 90 days of treatment showed 68.99 % (P<0.01) decrease in the Fat mass at 250 mg/kg dose and 72.84 % (P<0.001) decrease in the Fat mass at 500 mg/kg dose when compared with the obese control group. The pancreatic lipase activity in 250mg/kg (5.13+0.71 U/mg of protein) and in 500 mg/kg (4.01+0.86 I/mg of protein) reduced significantly (P<0.001) when compared with the obese control group (9.73+2.39 U/mg of protein) Conclusion: The ZMBP has anti-obesity activity at 250 mg/kg and 500-mg/kg dose. It has lipase inhibitory activity.

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Purpose: Cerebral palsy being a non-progressive disease presents with a gross delay in the motor milestones according to particular age. This delay depends on the number, location and severity of the lesion inside the brain. In this study, Ayurvedic drugs and procedures with established beneficial role in the management of neuromuscular conditions were evaluated for effect in delayed mile stone management in Cerebral palsy. Method: Clinical trial was undertaken for total duration of six month. Patients were selected in age group 1-12 year from O.P.D. /I.P.D. Of Bal Rog department, National Institute of Ayurveda, Jaipur. Assessment was performed at the end of every month using CDC scale of milestone assessment. Total 51 patients were registered and randomly divided in three groups, A, B and C having different procedures. Six cases in each group had discontinued the trial, hence the results were analysed based on data generated from 33 patients. Result: Neck holding scale in group A presented with 15.62% improvement while group B presented with 29.41% results and group C presented with 39.39% improvement. In sitting scale, group A presented with 23.81% changes while group B and group C presented with percentage improvement of 38.71% and 55.55% respectively. Standing scale presented with percentage improvement of 75%, 75% and 85.71% respectively in-group A, B & C. The inter group comparison with ANOVA test shows in neck holding group C was found statistically significant (p<0.05) over group A, while in sitting scale group B was found statistically significant (p<0.05) with group A while rest of the other comparisons were found statistically insignificant (p>0.05). Conclusion: Hence it can be concluded that Ayurvedic modalities present in the group B and group C produce better results than group A.

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Purpose : To specify the role of Ayurvedic medicine along with Agni karma in treatment of Ankylosing spondylitis, a chronic inflammatory arthritis and auto immune disease with a strong genetic predisposition Method : In present case study of AS with +ve HLAB27 and LDH (lactate dehydrogenase ) 624.1U/L( normal range 230-460U/L)with radiological abnormalities at the sight of L.S. spine AP and Lt. are symptoms of mild lumbar spondylosis with right sacro-iliac arthritis. The patient was having Vata and Kapha dominant symptoms like Amavata so he was subjected to therapy which performs removal of Ama and detoxification of toxins from the body followed by ruksh virechan with swadista virechan churna 5 gm in every 4 days once in night and Nadi sweda with dashmool kwath for 7days there after agni karma in every 15 days periodically along with hypothetical herbomineral combination up to 6 months as patient follows. Result: After 4 months of regular treatment all other typical features related to disease like amajeerna, shoola etc were also improved. In lab reports, HLAB27 became negative and LDH returned to normal range up to 294U/L .In radiological reports the fusion of vertebral column was also reversed as showed in AP view of X-ray imaging. This particular case has proved the importance of Ayurvedic medicine and Agni karma in AS. Conclusion: Ayurvedic intervention was found to be efficacious in management of Ankylosing spondylitis. Further studies are needed to establish efficacy on the basis of rigorous parameters.

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Purpose: Modern medical science treats psoriasis with PUVA, corticosteroid, anti-mitotic drugs which gives serious side effects like liver and kindney failure etc. There is a need to discover safe and effective medicine without any side effects for Psoriasis and the role of Leech Therapy (Shodhan) and Panchatikta Ghrita (Shaman Karma) is evaluated in this study. Method: 30 patients were included who matched the clinical signs and symptoms of psoriasis. These patients were randomised into three groups. Group A- Only on leech therapy, Group B-Only on panchatikta ghrita and Group C- On both leech therapy and panchatikta ghrita Result: Group A showed 45% improvement and group B showed 47% improvement, while group C reported 65% improvement. Conclusion : It can be concluded that shodan(leech application) along with shaman (panchatikta ghrita) is effective in the management of psoriasis as it is safe, cost effective and free from any side effects.

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Purpose: Mental health is the level of psychological well being and encompasses the abilities to develop emotionally, psychologically, intellectually, socially and spiritually. There is no health without mental health. Most common mental disorder is depression, anxiety & drug addiction. Major depressive disorder is a mental disorder characterised by an all encompassing low mood accompanied by low self esteem and loss of interest in normally enjoyable activities. Standard treatment for depression includes antidepressant medication which have unpleasant side effect and psychotherapy which is time consuming and expensive. Objective of the present study was to assess the effectiveness of a herbal preparation and shirodhara therapy for the treatment of major depressive disorder and to compare its effectiveness with a standard drug. Method: It was Open Randomised Controlled clinical Study. Study population was selected from OPD & IPD of Kaychikitsa department at NIA and OPD of Psychiatry, SMS Medical College & Hospital, Jaipur. Out of 42 screened patients, 30 patients fulfilling the DSM-IV criteria for diagnosis of depression were enrolled for the study and randomly divided into two groups. Group A was given standard drug fluoxetine 20mg orally BD for 42 days. Group B was given herbal preparation orally for 42 days with shirodhara by medicated plain Ashwagandha oil for 14 days. Observations were made on baseline day, 14thday, and 28thday and 42nd day of study. Result: Both the groups showed significant improvement, with no unpleasant side effect in Group B. Conclusion: Selected Herbal preparation and Shirodhara therapy can be used in mild & moderate condition of major depression with free of side effect.

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Purpose: Alopecia aerata is one among the most prevalent human autoimmune diseases, leading to disfiguring hair loss by the collapse of immune privilege in the hair follicle and subsequent autoimmune attack. Generally, hair loss in patches signifies alopecia areata. It typically presents a gradual or sudden loss of hair in head, eyebrows, eyelashes, nasal, ear and other areas of the body causing patches to appear. Alopecia areata or hair loss occurs in one in 1,000 people. Autoimmune-associated alopecia areata has no age boundaries and can affect even children, men and women equally. If left untreated, or if the disease does not respond to treatment, complete baldness can result in the affected area. The two major forms of Alopecia are scarring and non scarring. Highlighting the significance, a study was carried out to evaluate the therapeutic efficacy of Ayurvedic formulations in patients with Alopecia Areata. Method: Fifteen alopecia areata patients of either sex with varying degrees of hair loss were randomly selected for the clinical trial and were treated with Indralupta Bhasma, Malathyadi Tailam and Guduchi tablet for a period of 3-5 months. Subsequently, most of them were observed bi monthly up to a 5 months period. Result: Findings revealed that 8 of the15 patients with patchy progressive hair loss stabilised and showed no additional hair loss. After 3-5 months of treatment hair growth in these patients were partial or full. Of the other 7 patients with stable patchy total hair loss, four had some limited growth, two patients displayed complete growth of eyebrows and eyelashes, but had poor hair growth on scalp while one patient did not show any response. Conclusion: The study vividly indicated the efficacy of Ayurvedic formulations in patients with Alopecia Areata. The trial medicines too proved to be effective minimizing the patchy hair loss.

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Purpose: There is genetic variability in Terminalia species which is a very tall tree ranging from 5 to 30 meters. Government of India has established a tissue culture laboratory and the callus formation and differentiation tests were conducted at Ranchi, and it was found that this plant can be used for pharmacognosy and fibre. Method: In pharmacognosy, through tissue culture, anti-oxidative properties of ethanol extract of Terminalia bark was tested against sodium flouride induced oxidative stress in heart. The activities of various antioxidant enzymes, levels of cellular metabolites reduced carbonyl contents were already determined in the cardiac tissue. Tissue culture is a specialised area of production which should be exploited by Ayurvedic researches. Terminalia Arjuna was cultured on nutrient media supplemented with different concentration of phyto-hormones along with auxins and cytokinins implemented with coconut water. Result: Adenine Sulphate at the rate 25 mg/lt were added for nodal and auxiliary explants, and these nodal explants and shoot tips of T. arjuna were cultured again to have shoot proliferation. This can be used for other herbal plants for exploitation in medicinal and other useful purposes. In Ayurveda it can help in cost reduction and efficacy enhancement. Conclusion: Culture the new variety of Terminalia species can be developed with the help of tissue culture from Ayurvedic point of view, which can reduce the level of lipid profile, and angiotensin activity should be compared with others.

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Purpose: The smooth and glowing complexion of face increases the beauty of a person and also gives tremendous self-confidence. Vyanga is a disease which decreases the glowing complexion of face and affects the skin. Even though it is considered as kshudra roga (minor disease), it has got a major importance as a cosmetic problem in the society. It is characterized by the presence of painless and bluish-black patches on face. Treating this condition has become a problem, since safe drugs are not available for long term therapy. So the study was aimed to evaluate the efficacy of Arjunatwak lepa with Madhu and Panchanimba churna internally. Method: For clinical study, 30 clinically diagnosed patients were registered and divided into two groups with 15 patients in each group. In Group-A patients were administered with Arjunatwak lepa with Madhu for 21days. In Group-B patients were administered with both Arjunatwak lepa with Madhu and Panchanimba churna internally for 21days Result: In Group A, out of 15 patients, 09 patients were cured completely, which was statistically significant at the level of p<0.01. 4 patients have shown marked improvement, 2 patients showed slight improvement. In Group B, out of 15 patients, 12 patients had attained normal skin color, which was statistically highly significant at the level of p<0.001, 1 patient had mild improvement, 2 patients have moderate improvement. Statistically significant result was obtained in symptom bluish-black patch over the face. The clinical study has shown that combined therapy in Group-B gives better results than topical treatment. Conclusion: From the observations and results of this study, it can be concluded that combined therapy using Arjunatwak lepa along with Panchanimba churna have provided better results in depigmentation of the patches seen in Vyanga roga than local therapy.

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Purpose: In Ayurveda, physical and mental status of a person is described in terms of Prakriti. Manas prakriti is divided in three types as Satvik, Rajasik, Tamasik. Further these manas prakritis are divided as Satvik 7 types, Rajasik 6 & Tamasik of 3 types. (Su.sha.4/63).Though considerable body of research work is available on Deha prakriti, not much research work is available on Manas Prakriti. Rational Emotive Education is a preventive-interventionist approach by which a person can be taught sane mental health concepts and skills. REBT is based on a valid educational model which emphasises positive self-acceptance, critical thinking, the application of the scientific method to self-understanding, and behavioural change. Experiments with the program have shown that person can be taught to guide their actions through positive directed thought. Method : Phase I: Literary search - carried out by compiling & analysing work done on Mental Adjustment disorders. PHASE II: Nidanatmaka (Epidemiological) study. Survey based on the CRF prepared on the basis of phase one compilations incorporating Nidan, samrapti. More than 500 subjects were studied and analysed for pattern of Nidana Panchaka of Mental adjustment in Young Adults w.s.r. to Manas prakriti. PHASE III: UPASHYATMAKA (CLINICAL STUDY): About 100 Patients identified as suffering from Mental Adjustment Disorders in the Nidanatmaka study to be selected for the upashayatmaka Study after due process of Informed consent. These Patients to be divided into two groups: Group A (Rajasika): ‑ Sattvavajaya Chikitsa (REBT), Counselling as per the guide-lines of Rational Emotive Behavioural Therapy along with Yashtimadhu Ghan Vati. Group B (Tamasika): Sattvavajaya Chikitsa (REBT), Counselling as per the guide-lines of Rational Emotive Behavioural Therapy along with Tagar Ghan Vati. Result: Sattvavajaya chikitsa and drugs taken for trial were found to be effective. Conclusion: Manas prakriti has definite role in mental health problems

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Purpose: Cancer is one of the life threatening diseases spreading worldwide now a days. Oncogenes on one hand are well known to be activated by proto-oncogenes and are suppressed by tumor suppressor genes (TSG). There are different strategies for targeting to the regulation of tumor suppression gene. P53 is a most targeted gene that regulates the cell cycle and hence functions as tumor suppression to maintain the integrity of DNA. Method: In the present study p53 was used as a parameter to evaluate the efficacy of a new herbo-mineral compound LAS02 a cancero-static compound formulated by Lavanya Ayurveda Hospital and Research Centre Lucknow, in different type of malignancies such as breast cancer, bone marrow, hepatic, ovarian, head & neck carcinoma. The serum samples were taken from the cancer patients at Lavanya Ayurvedic hospital and was tested by solid phase sandwich enzyme linked immuno-sorbent assay (ELISA). Result: The main p53 valves before treatment more found to be 4.76 U/ml however, after treatment with our new herbo-mineral drug, the mean values of post treated p53 values were found to be significantly raised to 35.94 U/ml, which signifies the efficacy of treatment of LAS02 in enhancing the expression of p53 gene in different types of cancers. Conclusion: p53 protein is a guard of DNA and helps in enhancing repair of the damage of DNA done by cancerous pathology.

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Purpose: Opuntia elatior Mill. (Family: Cactacea) is a xerophytic perennial bushy shrub,1-3 m tall. It is native of Caribbean, Central America and northern South America, but actually it is fully naturalized in many part of the world like Mediterranean, Australia, Africa and India. Ripe fruits of this plant contain red pigment i.e. betanin which is betacyanin pigment. It is recently documented that natural food colors such as betanin can inhibit the cell proliferation of a variety of human tumor cells. In view of its traditional use and chemical composition, Opuntia elatior Mill. fruit was selected for its in vitro antileukemic and antioxidant activity. Method: The fruits of Opuntia elatior after collection, authentication and drying was extracted with hydroalcoholic solvent using maceration method. The present study aimed to determine the preliminary phytochemical evaluation, quantitative estimation of Betanin pigment, total phenolic, flavonoid and flavonone content with spectrophotometric methods, evaluation of antioxidant and cytotoxicity study of the hydroalcholic extract of Opuntia elatior on K-562 cell line ( Human chronic myelocytic leukemia) by MTT assay method. Result: The preliminary phytochemical evaluation showed the presence of carbohydrates, flavonoids, betanin pigment, tannins, sterols, proteins, pectin, citric acid and vitamin C. The total phenolic, flavonoid, flavonone and betanin content in extract were found to be 52.76 mg/g, 39.22 mg/g, 9.60 mg/g and 48.10 mg/100ml of extract respectively. Evaluation of antioxidant activity was carried out by DPPH free radical scavenging method. It showed significant activity compared with the standard. IC50 values for extract of O.elatior and Vitamin C was found to be 88.16 g/ml and 62.83 g/ml respectively. Conclusion: Its cytotoxic evalution showed a potent action against to K-562 (Human chronic myelocytic leukemia) cell line. It was found that hydroalcoholic extract of the fruits of Opuntia elatior Mill. have persuasive antioxidant activity and promising antileukemic activity.

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Purpose: Dhatura is an important deliriant poison grouped under sthavara upavisha and phalavisha. It affects the Central Nervous system. Dhatura is important ingredient of large number of medicinal formulations. In the Ayurvedic text,, Basavarajeeyam, Chincha Rasa (Tamarind) has been described to be possessing antidote action to counter toxicity of Dhatura. This study attempts to establish the activity and mechanism of action of chincha rasa against toxic effects of Dhatura by means of chemical analysis. Method: 1) Collection of drugs, 2) Authentication of three drugs in Govt. authorised institute, 3) i) Preparation of Chincha rasa (According to charaka), ii) Preparation of Chincha pakwa phal (According to Sharangdhar), 4) Physical and Chemical study of Dhatur seed, i) Preparation of Dhatur Churna (According to Sharangdhar) and Analytical Study of three drugs, 5) Methods of determination of an antidote. Result: Laboratory experiments were carried out to obtain values of specific parameters for Dhatur seeds, chincha patra ras (tamarind leafe juice) and chincha pakwa phal (ripe tamarind fruit). Conclusion: On the basis of observations and results found in chemical study and reported literature, the study came with the following conclusions. 1) The chincha patra rasa and Chincha pakwa phal rasa both contain Hordenine which has the antibacterial activity and stimulates the central nervous system providing relief from unquenchable thirst, muttering and delirium (indistinct and inaudible words unsteady gait) 2) Because of tannins, Chinchapatra ras and Chincha pakwaphal ras have astringent property, which counteract the toxic symptoms of Dhatur like dermatitis, rash and exfoliation of the skin. 3) Because of glycosides and tannins, chincha patra rasa and chincha pakwaphal have diuretic property which counteract the toxic symptoms of dhatura like urinary retention and inability to pass urine. 4) The tartaric acid present in chincha patra ras and chincha pakwaphal ras causes gastric irritation and thus induces vomiting. 5) Chincha patra ras and Chincha pakwa phal ras have flavonoids (Vit. P. and Citrin) which strengthens the blood vessels and lowers blood pressure and works as anti-inflammatoryagent. 6) The Chincha patra ras and Chincha pakwa phal ras have vit. 'C' which lead the blood circulation towards the heart which prevent the cardiac arrest produced in the Dhatura poisoning. 7) Chincha patra ras aqueous extract 1% and 10% has the pH of 5.91 and 5.45 and the pH of chincha pakwa phal ras aqueous extract of 1% and 10% has pH of 4.72 and 4.50. Both are acidic but the pH of Dhatura in aqueous extract of 1% is 8.19 and 8.00. Therefore, they neurtralize each other and reduce the toxic effect of dhatura. Similarly, the action of chincha rasa can be explained through the concepts of Ayurveda.

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Purpose: Homonoia riparia Lour,,Pedilanthus tithymaloides(Linn.) Poit and Phyllanthus fraternus (Medic.) Almeida (comb. nov.) belonging to family Euphorbiaceae was reported to be used in India to cure skin diseases. It was observed that the skin diseases caused by the fungi particularly by the Trichophyton species are very common in Mumbai. Hence, present study was undertaken to evaluate the antifungal activity of the extracts of the plants mentioned above. Method: Plants were collected from the wild and identified and authenticated by referring to floras and comparing with the herbarium specimens. Skin scrapings of the patients visiting G.T. hospital, Mumbai and Miskeek's pathology laboratory, Thane, for the treatment were collected and cultured on a dermatophyte culture medium (SDA supplemented with chloramphenicol and cycloheximide) and after several subcultures Trichophyton mentagrophytes and T. rubrum were isolated and identified by studying the colony characteristics and microscopic structure as suggested by Larone (1976). 20 % extracts of fresh and dry roots, leaves and flowers/fruits were prepared in distilled water and 20 % ethanol separately using the grinder. The extracts were filtered through Whatman No.1 filter paper and the filtrates were used to test the antifungal activity, The method used by Abubacker et al.(2008) was followed to test the antifungal activity.The extracts inhibiting the growth of the fungus were analysed for different phytoconstituents following the tests prescribed in pharmacognosy book (Kokate,2007), Result: It was observed that the extracts of Pedilanthus tithymaloides and Phyllanthus fraternus did not inhibit or delay the growth of the fungus whereas, the aqueous extracts of dry leaves and flowers (male) of Homonoia riparia inhibited the growth of T. mentagrophytes. The phytochemical analysis of aqueous extracts of the dry leaves and flowers indicated presence of Tannins, flavonoids, saponins, glycosides and alkaloids. Conclusion: Homonoia riparia (leaves and flowers) may have the potential to inhibit the growth of T. mentagrophytes.

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Purpose: The present study was conducted on 30 clinically diagnosed and confirmed patients of Coronary Artery Disease (C.A.D.). Patients having C.A.D. with specific conditions were not registered. The study was conducted with an objective of evaluating the role of Prabhakara Vati and Lekhana Basti in the management of C.A.D. On various scientific parameters. Method: 30 patients were randomly divided into three groups. It was a randomised, comparative; open ended, pre and post design, clinical trial. Out of the three groups, 10 patients were administered Tab. Dilzem 30 mg TDS for one month, 10 patients of second group were administered Prabhakara Vati 500 mg (two tablets) bd for one month and 10 patients were administered Lekhana Basti (for 15 days) along with Prabhakara Vati 500 mg (two tablets) bd for one month. Result: During present trial it was observed that there was significant improvement in clinical manifestations of stable angina after the therapy with Prabhakara Vati and Lekhana Basti. The level of S. Cholesterol, L.D.L., V.L.D.L. and Serum Triglycerides decreased and the level of H.D.L. increased considerably after the therapy. Conclusion : Prabhakara Vati and Lekhana Basti possesses potent antianginal and cardio protective activities and it can be used effectively in the management/to slow down the progress of pathogenesis of atherosclerosis leading to various Hridrogas (C.A.D.) specially stable angina.

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Purpose: The burden of modern lifestyle leads to many mental disabilities like Generalized Anxiety Disorder. It is necessary to find safer and simple regimen for Generalized Anxiety Disorder. Traditionally Swetashankhapushpi (Clitoria ternatea) is being used in Kerala to treat mental disorders including Generalized Anxiety Disorder (Chittodvega). Relaxation Techniques of Yoga are one of the tools to treat Anxiety Disorder. Method: The present work was done to study efficacy of Swetashankhapushpi and Clinical Yoga Techniques on 30 patients of Generalized Anxiety Disorder. These patients were randomly divided into A, B and C groups, consisting 10 patients in each group. Patients of Group A were given Swetashankhapushpi root powder 2 gm orally b.i.d. with milk as anupan for 1 month. Patients of Group B were on Clinical Yoga Techniques for 1 month. And patients of Group C were given both Swetashankhapushpi and Clinical Yoga Techniques for the period of 1 month and results were assessed by using Hamilton's Anxiety Rating Scale. Result: Combination of both Swetashankhapushpi and Clinical Yoga Techniques showed highly significant relief (P<0.001) than single therapy, providing overall improvement in Generalized Anxiety Disorder. Conclusion: Swetashankhapushpi (Clitoria ternatea) and Relaxation Techniques of Yoga in combination showed significant relief in Generalized Anxiety Disorder (Chittodvega).

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Purpose: Klaibya (Male Sexual Dysfunction = MSD) is common among men of all ages, it has been recently estimated that more than 152 million men worldwide experienced sexual dysfunction in 1995, and that this number will rise by 170 million, to approximately 322 million by the year 2025. In the past years, it has been reported that most of the hypertensive patients having disability to perform sexual acts and comes under the MSD. To keep these facts in mind the present study aimed to evaluate the efficacy of the Gokshuradi Vati in the management of Klaibya with or without hypertension. Method: The patients identified and classified as suffering from klaibya with or without hypertension participated in the clinical trial in three groups. The trial drug Gokshuradi Vati (Su.) 2 tabs of 500 mg with anupana of GOKSURADI KWATHA 10 ml. was be administered to all the patients for 1 month. All the Patients were assessed on the basis of subjective and objective criteria. Result: The results showed statistically significant improvement in high blood pressure. Beside these, highly significant improvement was found in sperm count, serum testosterone level and IIEF-15 variables. Conclusion: On the basis of the results this study concluded that hypertension and klaibya are having a strong relation in each other's pathogenesis. On the basis of our study, we can say that every patient of hypertension should be examined for Klaibya.

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Purpose: Swarna-Vanga (SV) is a famous Kupipakva metallic preparation, which are therapeutically used as rejuvenator, anti-diabetic, and for testicular regeneration (Spermatogenesis) etc since 18th century. It contains Parad (mercury-Hg), Vanga (tin-Sn) and Gandhaka (Sulphur-S) in major amounts and our ancient author use different proportion of mercury in SV with respect to tin. So, in present study an attempt has been made to evaluate testicular regeneration property of SV with its safety and efficacy on albino rats. Method: 1. Pharmaceutical Study: Preparation of SV in different proportion of Sn:Hg as 1:1,1:1/2, 1:1/4, 1:1/6. 2. Experimental Study: a) Toxicity study of SV for short (14 days) and long(40 days) duration in different doses, b) Regeneration property of SV on induced CdCl2 (Cadmium Chloride) testicular germinal epithelium of albino-rats. Result: SV is a metallic preparation which contains mercury, tin and sulphur in major amount and the best product of SV is made by half of the mercury with the tin. SV does not show any toxic effects on therapeutic dose (12.5-25gm/body weight of albino rats) but show some toxic effects on higher dose in longer duration. The ability of SV in generation of testicular germinal epithelium is seen on partial damaged testis which is produced by inducing CdCl2. Conclusion: 1) The presence of mercury at least in half proportion to tin in is necessary in making the SV of good standards, 2) SV is not toxic in therapeutic dose and is slightly toxic on higher doses in long duration, 3) SV has the property to regenerate partially damaged testicular tissue.

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Purpose: Pratishyay basically is a Vat-kaphaj disorder arising from accumulation of vitiated Vat along with kaph-pitta-rakta in uttamang (shirh pradesh) and comparable to Rhinitis which describes a group of symptoms including runny nose, stuffiness, sneezing usually due to common cold, environmental irritants and immunodeficiency. This study aim to do 1.Evaluation of effectiveness of Vyoshadi gutika (samshaman therapy) and Pippalayadi churna Avapida nasya (samshodhan therapy) in the management of pratishyay, 2.Statistical assessment of data post treatment. Method: 60 patients of Pratishyay aged between 16-60 years of age of both sexes complaining of Rhinorrhoea/ nasal block, sneezing, heaviness of head, anosmia were selected randomly and assigned for clinical study were divided into 2 groups. Group A consisting of 30 patients had internal administration of Vyoshadi gutika in a dose of 2 tablets QID (each tab. 375 mg) with lukewarm water for 30 days. Group B- 30 patients took Vyoshadi gutika along with Pippalayadi churna Avapida nasya (6 drops in each nostril early morning) for duration of 21 days. All patients were advised to attend 15 days Intercal regularly for 3 months for assessment of disease through subjective and objective parameters. Result: 60% patients (18 no.) of Group B while 47% patients (14 no.) Group A responded satisfactorily with maximum improvement (more than 76% symptomatic improvement). Similarly, Moderate improvement (between 51-75%) was seen in 47 patients of Group A and 37% of Group B while mild improvement in 10% and 3% patients of Group A and B respectively. No untoward adverse effects were seen in any patients. Conclusion: It can be concluded that on the basis of Practical, Therapeutic and Statistical analysis, patients of both groups got satisfactory improvement. Besides, patients treated with both Samshodhan Nasya therapy and Samshaman Vyoshadi Gutika therapy comparatively got better results.

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Purpose: Beauty has very important role in our life. Hair plays very vital role in our beauty. A human body without hair would be seen just as a tree without leaves. So everyone has an ambition that his/her hair should be long, black and thick. In Ayurveda there are many synonyms for Hair loss as Inderlupta, KhaIitya, rujya etc. Indralupta is a unique, idiopathic, non-cictricial, non-inflammatory alopecia, presents as discoid areas of hair loss. Method: Therapeutic assessment of lepa of sodhita langalimoola was carried out on the patient of Indralupta. Lepa of the fine powder of langali moola was made with madhu. External application was done twice a day for a period of 60 days. Selection of Cases Source: For the present study, patients with Indralupta were screened out from OPD & IPD of NIA, Jaipur. Number of cases: 30 Patients were registered from OPD & IPD of NIA Jaipur. Grouping of Patients: Selected patients were randomly divided into two groups. Group A: This group of 15 patients was treated with Gomutra sodhit Langali moola with honey for external application. Group B: This group of 15 patients was treated with Godugdha sodhit Langali moola with honey for external application. Result : It was observed that after 60 days of treatment with Gomutrashodhit Langlimool in Group A there was reduction in Hair fall which is statistically highly significant( P<0.001) and highly significant improvement was observed in reducing dandruff.(p<0.001). Where as in Group B Godugdashodhit Langlimool application reduced the hair fall to statistically significant level (p<0.01) and statistically significant in reducing the dandruff in patient with Indralupta (P<0.01). Conclusion: Gomutrasodhit Langali moola churna was highly effective in the management of Indralupta.

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Purpose: WAvascular necrosis is newly emerging disease with increasing incidence involving one or both hip joints. It is progressive disease however no drug is found yet in modern medicine to stop its progression. Hence to evaluate the effect of certain Ayurvedic treatment on the progression of this disease, this clinical study was done. Method : 1)10 patients having Avascular necrosis of either of hip joint less than grade III were selected irrespective of age, sex, religion and occupational status. 2) Two major complains i.e. Vankshan sandhishool (Pain) and Vankshan sandhigraha (Stiffness) were considered. 3) These two complains were scored as per severity before and after treatment. 4) Vidhivat Panchatikta ksheerbasti 120 ml in morning after breakfast and Aabha guggulu 500 mg in Pragbhakta kala (15 min. before lunch and dinner) with Goghrita orally was given daily for 1 month. 5) Pachan and Anuloman was given as per requirement during treatment. 6) The score before treatment was compared with the score after treatment. 7) The total relief in each complains was calculated in percentage. Result: 1) Total score of 10 patients for Vankshan sandhishool (pain) before treatment was 24 and after treatment was 10. The difference was of 14 and hence relief was 58.33%. 2) For Vankshan sandhigraha (stiffness), score was 24 before treatment and 12 after treatment. The difference was of 12 and the relief was 50%. 3) The combine score of 10 patients was 48 before treatment and it was 22 after treatment. The difference was of 26, the total relief was 54.166% Conclusion: The Ayurvedic treatment of Vidhivat Panchatiktaksheerbasti and Abha guggula was found to be effective in preventing progression of avascular necrosis of hip joint.

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Purpose: Modern treatment for dantasharkara is antiplaque agent and scraping but it causes discolouration, dantakshaya and dantaharsh (hypersesitivity). Ayurved advocates lekhankarma and Arimedadi pratisaran. Charaka, Bhavprakasha and Yogratnakar Arimedaditaila as mukhrognashaka. The present study aimed to study the effect of lekhankarma karma and Arimedadi Tailam on dantasharkara. Method: 30 patients having dantasharkara were selected and scaling done with ultrasonic maschine in control group. In trial group, scaling was done in thirty patients followed by Arimedadi Tailam pratisarana for two times a day for one month. Result: After scaling the Dantasharkara in both groups was persistent on third day but after 90 days only 4 patients had the problem in trial group and 25 patients in control group. Dantaveshtashoth, putiasyata and puyaraktasrava were relieved but in the next follow up, recurrence was observed in control group whereas in trial group there was no recurrence. Conclusion: Recurence of Dantasharkara is delayed. Dantaveshtashotha, putiasyata and puyaraktastrava got reduced immediately and there was no recurrence. Arimedadi Tailam does not produce dantaharsha symptom after scaling. Arimedadi Tailam has number of drugs, which acts as raktastambhak, shothahar, kaphavatashamak and mukhadurgandhinashak on account of which it reduces above symptoms and also prevents dantaharsha and dantakshaya.

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Purpose: Increase in the lateral pressure exerted by the flowing blood during the contraction of the heart is termed as SYSTOLIC HYPERTENSION, which causes adverse effects on many organs including vital organs and leads to multi-organ failure. Many medications acting at different levels are available in the conventional medicine, which are far from satisfactory and hence there is a need to find out cost effective and satisfactory alternatives. Method: 30 newly diagnosed middle aged (30 to 50 years) patients of either sex with a range of 140 to 160 systolic blood pressure (Diastolic B.P < 90 mm.of Hg) were recruited for Tila Taila (Oil of Saeasum Indicum Linn) Shirodhara 30 minutes daily for 14 days. Blood pressure was monitored in the morning, before and after Shirodhara, in evening and the record was analysed. Result: It was observed that on 1st day Systolic B.P reduced by 4 to 8 mm.of Hg at the end of Shirodhara, but remained the same as initial blood pressure by the evening. At the end of the 7th day B.P reduced by 8 to 12 mm of Hg after Shirodhara and B.P was low by 6 to 10 mm of Hg in the morning and evening. Similar results were observed on 14th day. A striking observation was made that those patients having heaviness in the chest did not complain of the symptom after first week of Shirodhara. Feeling of well being and sound sleep was also reported after starting the treatment. Conclusion: Hence, it can be concluded that non-invasive modality like Shirodhara which is devoid of any unwanted effects can be used for control of systolic hypertension.

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Purpose: Ashtavidh rogi pariksha one of the main diagnostic methods described in Ayurveda includes Mutra Taila Bindu Pariksha (MTBP), which is simple and cost effective. Modern diagnostic investigations of tumor markers and radiological procedures are costly and usual tests for recording different stages of cancer. MTBP is also used at Lavanya Ayurvedic Hospital in Cancer patients as diagnostic and prognostic parameters. Test depends on pattern of spreading of oil drop over surface of patient's urine. Method: This procedure was modified keeping all parameters fixed like distance at which sesame oil falls and procedure of collection of urine sample. This equipment was attached with a photographic device. 50 randomly selected cases were divided into two groups. Group I consisted of 10 healthy volunteers and group II consisted of 40 pre diagnosed cases of different types of cancer. Patients were made to sleep at 9 PM. On next morning (5 AM) mid stream urine of the first urination was collected in a standard sized beaker of 250 ml. Sample beaker was kept in a specifically designed glass and fibre cabinet, which was devoid of air. A 10 ml glass burette filled with Tila taila (Sesame oil) was fixed over beaker containing urine. One drop of sesame oil was dropped over the stable surface of urine from a distance of 2 cm. The oil drop dispersal pattern on the surface of collected urine sample was recorded photographically. It was analysed periodically at monthly intervals for three times. Result: The results of oil spreading nature, direction and shape over urine surface were compared with modern biochemical, haematological and radiological parameters in different stages of cancer. Conclusion: The pattern of dispersal of sesame oil was progressively changed in relation to the improvement in subjective and bjective parameters in LAS01 treated cases.

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Purpose: The symptoms of an allergic reaction communicate sensitization to certain antigens in the environment. Initiation of antigen reaction stimulates mast cells to release histamine into the blood which interacts with the cells to produce most of the symptoms of the allergy. Drugs that block only the action of histamine are known as antihistaminic while the drugs preventing mast cells from releasing histamine are considered as anti allergic agents. Ayurveda considers Mandagni (Jadharagni in hypofunctional state) as the root cause of the all diseases which produces Ama (Antigen/Visha). Drugs possessing Deepan, Pachan, and Vishaghna properties may prevent histamine release and allergic reactions. Udardaprashamana, Kandughna, Swasahara group of drugs may prevent acute histaminic reaction. Keeping this concept in view a critical review was made about the herbs mentioned in the classical Ganas and aushadhyogas of compilatory works of medieval India in addition to reported activities during 20th century research works. The study aims to identify herbs with Antihistaminic and Antiallergy activity and to discuss safety and efficacy of herbal anti histaminics over the drugs of modern medicine which may produce certain adverse effects like nausea, drowsiness, nasal burning etc. Method: Analysis of drugs mentioned in the management of pratishyaya, shwas, kasa, and skin conditions like Seetpitta, Udarda, Vicharchika etc. was made. Review of research data mentioned in various journals and monographs was also analysed. Result: Vishaghna and Udardaprashamana dashemani may have profound activity in controlling allergic reactions. Kandughna Dashemani may be useful to control fungal and allergic skin diseases. Pippali, Tulsi, Kantakari may be useful in the management of allergic disease of respiratory tract. Azadirachta indica (Nimba), Albezzia lebbeck (Shirish), Glycerrhyza glabra (Yashtimadhu) etc. have provided ample scientific evidence for antihistaminic activity. Conclusion: Recent researches confirmed Anti histaminic and Anti allergic activity of Adhatoda vasica (vaasaa), Aloe vera (kumari), Azadirachta indica (nimba), Curcurma zedoaria (karchura), Nigella sativa (upakunchikaa), Inula racemosa (pushkarmoola), Tinospora cordifolia (guduchi), Benincasa hispida (krushmanda) etc. which are safer to use.

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Purpose: According to WHO report 2002,Cardiovacular diseases (CVD) will be the largest cause of death and disability in India by 2012 . Metabolic Syndrome (MetS), a constellation of dyslipidemia, elevated blood glucose, hypertension and obesity is emerging as the most common risk factor for CVD. The rising prevalence of individual components of Metabolic Syndrome is mainly attributed to globalisation which has made available cheap, unhealthy food on the main menu & also brought with it sedentary lifestyle. It is a need of time to pay due consideration on the problem and search for alternative medicine. So the aim of the study is: 1.To study the impact of globalisation on health w.s.r Metabolic Syndrome. 2.To assess the clinical efficacy of Panchakarma in its management. Method: For the study large-scale survey, other documented data and published articles were studied. For clinical contrieve 20 patients were registered and were given Virechana Karma followed by administration of Shuddha Guggulu as palliative measure. Result: The results show that globalisation has a great impact on all the components of Metabolic Syndrome. However on management with Panchakarma (Virechana Karma) followed by Shuddha Guggulu encouraging results were found. The overall effect of therapy was found to be 82.5%. Conclusion: There is a high prevalence of metabolic syndrome in India and it is a need of time to consider alternative treatment for its management alongwith change in lifestyle to reduce the risk of cardiovascular disease.

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Purpose: In original Ayurvedic classics viz. in Caraka Samhita & Susruta Samhita, thousands of Medicinal plants and their parts are prescribed in various diseases. Medicinal Plants are not available at one place, rather found at different part of our country i.e. Vatsanabha, Jatamansa, Devadaru, in northen India (Himalaya region); Agara, Paga, in Eastern India; Samudraphala, Kupalu, in southern India and Guggalu, Asvagandha, in western India. These are a few examples; many more can be seen in Ayurvedic texts. It is worthy to mention here that seed, root, root bark, stem, stem bark, tuber, rhizome, leaf, flower, exudate, latex, fruit etc. are the various plant parts which are used to prepare medicine in Ayurveda. Further, those parts are not available in one season and also at one Geographical region of our country. To a physician or to a Ayurvedic scholar, it is not possible to see all plants as they are grown in different regions. For proper knowledge they are required to be kept at one place, where one can see and acquire practical knowledge.Thus Museum is the best place to keep them in best condition. Its also essential as per CCIM norms. So all about brief study of dravya guna museums importance, maintenance and related problems & solution is given. Method : Method of glycerin preservation is adopted 50% glycerin + 50% hot water mixed with 1 tab of aspirin and put the plant part for 15 days then dry and mount. Result: this type of preservation has long term stability without loosing there normal color elasticity and texture. Conclusion: this is new and betters method for making herbarium preservation with lower cost for long time.

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In spite of the advances that have been made, the management of chronic wounds is still a challenge for the physician. In the present study, an attempt was made to develop simple and effective treatment for the management of chronic wounds that are not responding to conventional treatment modalities by using Thila lepa as an external wound application. Present study was conducted to evaluate the effect of selected herbal place Thila lepa in the management of chronic wound. Randomly selected 60 cases of chronic wound were assigned in to two groups. The test group was treated with the selected herbal paste. While the control group being treated with Rogane Kaash Cream. The effects of the treatment were evaluated on the basis of wound area, amount of discharge, oedema, itching, pain and tensile strength of wound. In this study among 30 cases 24 (80%) cases have got the wound completely healed. The result of the present study reveals that the application of Thila lepa successful external application consisting of wound healing properties in the management of chronic wound.

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Purpose: Utilization of herbal remedies for prevention & management of various risk factors for diabetes: Use of Plant medicine due to minimum side effect & low cost. Aim: To analyse powder of Insulin Plant leaves according to modern analytical method; To apply suitable standards for Insulin Plant by using modern control techniques; To standardize herbal drug Insulin Plant for acceptance & globalization of Ayurveda at international level; To prevent adulteration with the help of accurate physicochemical values of herb. Methods: Authentication of drug: Morphology; T.S of leaf. Analysis of drug: pH value, Loss on drying, total ash, Acid insoluble ash, Water soluble extract, hin layer chromatography. Results: Photographs of T.S. of leaf will be present in poster.pH 8, Total ash 15.5%, Loss on drying 0.48 gm%, Acid insoluble ash 0.1%, Water insoluble ash 0.17%,Water soluble extract 38%, Alcohol soluble extract 8%, report of TLC is awaited. So it will be present in poster. Conclusion: With the help of standardized Physicochemical values herbal drug Insulin Plant will be accepted & globalized international level & will be prevent adulteration with the help of accurate physicochemical values of herb.

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Purpose: Mayur Puccha bhasma (Calx of peacock feather), an Ayurvedic animal product prepared from peacock feather with different methods mentioned in Siddhayogasangraha, Bhaishajya Samhita. It is mainly indicated in Chardhi, Hikka, and Swasa. Till today no research work has been done on Mayur Puccha bhasma prepared by two different methods and exact pharmacopeial standards are also not available. The present study was aimed to assess the Physico chemical components of Mayur Puccha bhasma prepared by Ghee flame and Gajaputa method & to lay down the Pharmacopeial standards for the assessment of its standard qualities. Method: Mayur Puccha bhasma was prepared by two classical procedures, one by burning on ghee flame (Sample A) second by giving four Gajaputas (Sample B) and finished products were subjected to various Physico chemical studies to find out Ash value, PH value, Sp gravity, Moisture content, Preliminary organic analysis and Gravimetric analysis. Result: Both the bhasmas exhibited marked difference in colour, moisture content and % of inorganic compounds. The bhasma prepared by Gajaputa method contains essential and beneficial inorganic elements, electrolytes in more quantity with less moisture content, neutral pH. Conclusion: Sample B is having less moisture (1%) content which may contribute for increasing its stability and having high ash value as it consists of inorganic elements in more quantity and indicates that bhasma prepared properly. The neutral pH of Sample A and B indicates no significance difference in their pH value. Sample B contains Copper, Iron, Zinc, Sodium, Potassium, Calcium, Magnesium, Manganese, Aluminium, in more quantity than Sample A but in a permissible amount. As Mayur Puccha bhasma prepared by Gajaputa method contains essential and beneficial elements, having natural pH and free from steroids may contribute as one of the usefully and safe alternative medicine in Chardhi, Hikka, Swasa.

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Purpose: Mild cognitive impairment (MCI) is a frequent clinical entity, considered today to be a prodromal stage of Alzheimer's dementia, but not having until now a standardized pharmacological treatment. The aim of this study is to follow the outcome of the patients diagnosed with MCI non treated and treated with nootropics, alternative herbal agents, and cholinesterase inhibitors. Method: The study comprises a number of 200 patients (over 60 years) diagnosed with MCI. The patients were evaluated using MMSE (Mini Mental State Evaluation) at the inclusion into the study and after 1 year of treatment. The patients were divided in four different groups: Group A - 50 patients diagnosed with MCI treated with Piracetamum 1600mg/day, Group B - 50 patients diagnosed with MCI treated with Rhodiola rosea, 2 capsules/day, Group C - 50 patients diagnosed with MCI treated with Galantamine (16mg/day), Group D - 50 patients diagnosed with MCI non treated Result: The average of MMSE scores at screening was 23.96 points for group A, 24.16 points for group B, 23.96 for group C and 24.5 points for group D. After 1 year of treatment, cognitive performance improves with 2.12 points for Group A, 1.97 points for Group B, 2.04 points for Group C and without any improvement for Group D. Conclusion: Comparing the outcome of treated and non-treated groups, we observed that the early treatment of mild cognitive impairment delay the transition to dementia. The outcome of the treated groups after 1 year of pharmacological treatment was approximately the same. This study proves the necessity of early treatment and of the enlargement of therapies in mild cognitive impairment. The acceptance of nonconventional therapies can change the relationships between physicians and well educated patients who more frequently advocate for a broad range of treatment choices.

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Purpose: The drug optimization and understanding the mechanisms of action of drugs on the deregulation of cell cycle which is frequently considered as the cause of progression in cancer can provide important insights for new cancer treatment strategies. The drug LAS02 is a herbo mineral drug prepared as per ancient Ayurvedic literature. Method: In this study the effect of LAS02 was studied by analyzing the effect on cell cycle by flow cytometery on cancer cell lines breast cancer (MCF7), cervical cancer (HELA), colon cancer (COLO 205) and prostate cancer (DU 145), procured from NCCS, Pune. The cells were treated by different doses of LAS02, and assay for proliferation was performed by MTT assay test, subsequently, these were analyzed by flow cytometer for cell cycle analysis. Result: The results showed inhibition of proliferation in MCF7 by 77% and HELA cells by 78% at dose of 500μg/ml in MTT assay. In cell cycle analysis for COLO 205 treated with LAS02, the percentage retention of the cells in G0/ G1 phase was 73.07% at 300μg/ml as compared to 52.16% in the control after 24hrs. In DU 145, treated with LAS02, cells that retained at G0/G1 phase were 79.28% at a dose of 400μg/ml after 48hrs; as compared to control of 62.41%. The apoptosis observed at 400μg/ml drug concentration was 43.51%. Conclusion: The study shows that LAS02 acts as a potent anti cancerous compound by inhibiting proliferation as well as by inducing retention of cells in G0/G1 phase along with apoptosis significantly at in vitro level. Therefore, LAS02 arrests the cancerous cells in G0/G1 phase and prevented the entry of pre cancerous stem cells from G0/G1 phase into G2, the subsequent proliferative stage and inhibits cancer cells from completing the cell cycle. Such a finding is unique with this new drug, which holds a great promise as one of the most effective and safest cancerostatic drug.

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Purpose: Pranayama is the science of breathing and essence of being alive. It is the axis around which the entire life cycle resolves. Health is a state of complete physical, mental and social well being and not merely an absence of disease or infirmity. Pranayama is compound word consisting Prana and Ayam, Prana means vital energy, breath, air etc. Prana is the vital life force that acts as a catalyst in all Physiological function and Ayama the expansion or control of this force. Method: Pranayama is a relatively simple, rhythmic, low cost intervention that can be incorporated into people's daily routine and have a positive impact on health. Maharishi Patanjali places Pranayama as the fourth limb of Ashtanga yoga. Prana is the fundamental basis of whatever is, was and will be. It consists three phase Purak, Kumbhak, Rechak. Result: Many researches show that breathing exercisesimprove respiratory physiology by increasing vital capacity and maintain homeostasis in blood. Researches show that pranayama is also helpful in improving the digestive activity by boosting enzymes action and promotes clearance of subtle metabolic wastes from the body. Conclusion: The process of breathing, vertical breathing is the more efficient way to inhale air than horizontal way. The present paper is high light the importance of pranayama in maintaining health, through previous research and contemporary concept.

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Purpose: Vandhyatva (infertility) has been long standing problem since ancient period. Many herbal and herbo mineral formulations are mentioned as a treatment of infertility in the ancient texts, but they are not categorized according to the responsible factor like Ritu Kshetra, Ambu, Beeja. It is the need of time to evaluate the efficacy of formulations in respect to various factors of infertility. The objective was to evaluate the efficacy of Aswagandha Ghrita and Phalaghrita in the management of Vandhyatva w.s.r. to cervical factor. Method: In this study, total 14 patients were treated in two groups viz. Group A; Ashwagandha ghrita (Intra cervical Uttarbasti 6days for 2 cycles and Ghritapana 15ml bid for 2 months) and Group B; Phalaghrita (Intra cervical Uttarbasti 6days for 2 cycles and Ghritapana 15 ml bid for 2 months) to assess the role of Ghrita in the management of Vandhytva. Sim's hunter and Moghissi cervical mucus Test and Post coital test were selected for the diagnosis and for evaluation of efficacy of therapy on cervical factor. Result: The overall effects of both the therapies on properties of cervical mucus showed that the administration of Ashwagandha ghrita (group A) was more effective to increase the amount and tradability as compared to Phalaghrita whereas Phalaghrita was more effective in comparison to Ashwagandha ghrita to decrease the cellularity and viscosity of cervical mucus. Conclusion: Significant results were found in both the groups, but Ashwagandha ghrita provided better results in comparison to Phalaghrita.

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Purpose: Present study was carried out to investigate antiulcer activity of Normacid powder in diclofenac and pylorus ligated induced ulceration in the albino mices. Method: Preliminary normacid powder was subjected to the acute oral toxicity study according to the OECD guideline no. 425. Based on which, two dose levels i.e. 250 and 500 mg/kg were selected for the further study. Various parameters were studied viz. gastric juice volume, pH, total acidity, free acidity, ulcer index, percentage inhibition, anti oxidants parameter, mucin level and mucosal nitrate level of ulceration was determined for diclofenac and pylorus induced ulcer model. Ranitidine at 20 mg/kg was used as the standard drug. Result: Pre-treatment of normacid powder showed significant (P<0.001) decrease in the gastric volume, total acidity and free acidity. However, pH of the gastric juice was significantly (P<0.001) increased only at higher dose, 500 mg/kg. It showed also significant (P<0.001) decrease in number of ulcers and ulcer score index in diclofenac and pylorus ligation induced ulceration models. The increase in the level of superoxide dismutase, catalase, reduced glutathione and decrease in lipid peroxidation in both the models showed the antioxidant activity of the formulation. Also increase in mucin and mucosal nitrate level in both models showed the cytoprotective activity of the formulation. Normacid powder possesses significant antiulcer properties in a dose dependent manner. Conclusion: In conclusion the antiulcer properties of the normacid powder may be due to the modulation of defensive factors, improvement in gastric cytoprotection and due to antioxidant property.

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Purpose: Ayurveda is eternal science of life because of its evolution is prior to human being itself. Ayurveda is part of our day to day life as a food & day routine. The study was performed as a survey in Delhi NCR (India) among the common men who use ayurveda or want ayurveda to be their system of medicine. The Aim of this study was to know their opinion that what are the ground realities and how ayurveda can be made more affordable and acceptable to them. Method: Sixty individuals were selected randomly comprising equally males and females. Age group was 18 to 70 yrs. All of them have undergone Ayurvedic treatment or have taken ayurvedic medicines as a part of their treatment. They were asked 31 questions about ayurveda under four categories as general questions, questions related to ayurvedic physicians, questions related to ayurvedic retailers and questions related to ayurvedic manufacturers. Their answers were taken on a printed questionnaire as a tick Yes, No and can't say. Some questions were subjective to get suggestions of patients. Result: Result of the survey indicated some valuable points like 90% under study doesn't know that BAMS are Ayurvedic Physicians. Pure Ayurvedic Retailers are rare; condition of ayurvedic medicines were not good at mixed ones. There was absolute majority for the expiry date on ayurvedic medicines & more research work on Ayurvedic preparations to make them tastier, easily differentiable & patient friendly. Conclusion: The results of the study should be addressed by the Ayurvedic Physicians, Ayurvedic manufacturers and retailers community on priority basis. The study also revealed the need of a broad based survey to get further insight of the present ayurvedic scenario in India & abroad and suggestions to make ayurveda more patients friendly and acceptable to all.

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Arthritis was known to mankind as "Sarjumshotham" from antiquity. This was known to Indian Ayurveda since 3000 years as a disease with painful swellings of joints and ligaments. This is the greatest and uncommon or less known crippling disease of unknown causation, infesting, claiming and involving maximum loss of human working power. The latest survey in US showed 11 million persons suffering from arthritis, consisting of about 6.4% of total US population. It is now widely spread in different parts of the World especially in temperate zones and with largest sufferers in India, Central America and Mediterranean countries. The onset of the disease is usually between age of 20 60 with two peaks at 35 and 45 years respectively. In clinical population, the females are more susceptible to disease than males and the ratio being 2 3 females to one male. Methodology: Ethnomedicinal surveys were undertaken during 2006 2009 in 42 tribal pockets of Adilabad district, Andhra Pradesh, India with good forest cover. The study area lies between 77° 47' and 80° 0' of the eastern longitude and 18° 40' and 19° 56' of northern latitude. Interviews were conducted with tribal vaidhyas belonging to Gond, Lambada and other tribal communities at their dwellings. The data were verified in different villages among the interviewers showing the same plant sample. The knowledgeable informants and medicinemen and vaidhyas were taken to the field and along with collection of plants for the voucher specimens, method of application, preparation of dose and mode of administration of the plants as given by the tribal informants was recorded. Each practice was cross checked with at least 4 5 informants.The survey yielded 8 plant species belonging to 6 families of Dicotyledons used to combat arthritis. Based on habit, herbs include 1species, followed by shrubs 2 and trees are 5. While classifying plants depending upon the plant part used, leaf constitutes highest percentage (62.5%) of utilization for the purpose and stem, stem bark and root 12.5% each. It is quite interesting to note that 1 plant viz., Dolichandrone atrevieres (Roth.) Sprague. And 5 practices are reported as new records after comparison with work of Jain (1991, 1997). Results: Most of the ethnic practices are now recognized to have specific beneficial effects in Ayurveda and the development of modern medicine. The methods of investigation employed by a traditional herbalist are not quantitatively different from modern chemotherapeutic investigation. In present day scenario, the herbal medicines and Ayurveda are gaining popularity and appreciated not only in India but also abroad. The knowledge and heritage of herbal medicines is an important source of information for scientific community, research workers and medicinal practitioners. It is high time now to conserve plants of medicinal value, bringing out light to ethnomedicinal practicesin Ayurveda as well as conservation and preservation of the original germplasm.

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Purpose: Carpal tunnel syndrome is an entrapment neuropathy of median nerve causing paraesthesia, pain, numbness and other symptoms in the distribution of median nerve due to its compression at wrist in carpal tunnel. Modern medicine prescribes surgery for its treatment. We report a case that was treated completely without any recurrence. Method: Case presentation: A female patient aged 23 years presented with numbness in the middle finger of left hand associated with paraesthesia, morning stiffness, loss of delicate movements of middle finger and dropping of small objects since 4 days. She consulted an allopathic doctor and was diagnosed as having Carpal tunnel syndrome (CTS). She was advised surgery. The patient was reluctant for undergoing surgery and took the medicines for 1 day, but had no relief. Next day she came to the OPD. On examination, Tinel™s percussion test and hand diagram were positive. On assessment, symptom severity scale (SSS) and functional status scale (FSS) were found to be 1.5 and 3.5 respectively, before treatment. Treatment given was varanadi kashaya, sahacharadi and supti taila, yogaraja guggulu, cap chelnar, dhanyamla dhara, shunthibaladi choorna etc, for a period of 1 month. The medicines were changed as per the condition of patient and the disease, at every follow up of 1 week, during the 1 month of treatment. Result: At the end of 1 month patient got complete relief from her complaints, and the scales SSS and FSS scored 0. Conclusion: The treatment given here aimed at release of compression by considering the involvement of doshas. The state of the disease was acute due to which complete relief was achieved. Thus if patients come to Ayurveda in early stages of the disease, prognosis will be better.

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Purpose: Thanks to modern lifestyle of indiscipline, man has become a pale shadow of his former self. His dependence on expensive medical diagnostics and care has put him into a state of mental depression. Our ancient masters have discovered many scientific principles and yogic techniques for healing man of his physical disease, mental inharmonies and spiritual ignorance. The aim of this study was to identify such simple techniques as man could use himself, thus reducing his dependence on costly medical intervention. Method: An extensive study and practice of scientific principles and yogic techniques as taught by many Indian masters, coupled with a similar research on diet and its principles from a variety of sources formed the basis for a practical research in Tarakeshwara Yoga and Research Centre in Visakhapatnam. All the techniques and methods were first applied on the self and then on a number of yoga students. Ancient principles of diet and basic Ayurvedic approaches were applied for first cleansing the body of its harmful toxins and for creating a body mind balance. This helped in stabilizing body metabolism and leading body parameters. It was then followed by targeting the specific body part that required healing through the direct application of designated yogic techniques. Result: The results have been simply astounding and immediate. A yogic technique applied just for a few minutes a day for a duration of not more than 3 - 5 days, eliminated dental pain and the need for any root canal treatment of of the exposed nerve. In another case, an excruciating pain in the ear was healed through a slightly different technique that was, however, based on a similar principle. The ear opened up releasing the watery discharge and eliminating the pain altogether with a soothing aftereffect. Conclusion: Heal thee thyself, O man! By Nature given scientific principles and techniques!

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Purpose: Each mineral is unique in this universe in its perception. Minerals are defined as naturally occurring, inorganic substances with a definite chemical composition and a regular internal crystalline structure (Gribble 1988). The identity of these depends on their physical, chemical or optical properties. Mineralogy a branch of science has its existence since 17th century. Being a part of Ayurvedic pharmaceutics, Rasashastra deals with a number of minerals categorized under Maharasa, Uparasa etc. These are identified on the basis of grahya lakshana mentioned in the books of Rasashastra documented from 8th century itself. Thus, it is evident that the science of mineralogy as it is practiced presently has its origin almost 1300 years back. 1.To find the features of minerals in the books of Rasashastra and to compare them with the properties of minerals as per Mineralogy. 2.To prove that the knowledge of identifying a mineral based on certain feature existed in India before development of mineralogy. Method: A literary research was undertaken to list out the grahya lakshanas of Rasadravyas mentioned in the literatures of Rasasashtra. An attempt was made to compare them with the equivalent properties of minerals. Only such literatures of Rasashastra which had their existence before 17th century were preferred for present study. Result: The grahya lakshanas mentioned in classical books of Rasasashtra were found to be very much comparable with the physical properties of minerals. Conclusion: This literary research justifies that the ancient scholars of Rasasashtra were able to identify the minerals based on their physical properties many centuries before the mineralogy had its existence.

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Purpose: Cosmetology is the branch, which deals with the Beauty treatment, and Skin care is a part of it. Due to the social cosmetic awareness in the society, there is increase in the demand and utilization of the cosmetic products. Most of these products contain chemicals such as dibutyl phthalate, formaldehyde, lye (sodium hydroxide), ammonia, and coal tar which are known to cause hazardous side effects to the skin like Allergies, photosensitivity and also Malignancies. This is a matter of concern in the society and alternatives have to be thought off in the form of safe and effective cosmetic agents. Method: Amongst the Fifty Dashemanis told in Charak samhita, Varnya Dashemani is one. Chakrapani in his commentary says Varnaaya hitam Varnyam, meaning that the one which enhances the colour complexion of the body is varnya. According to Ayurveda the health of the skin is dependent on Rakta dhatu, Ojas, and Pitta dosha. Any derangement in these factors leads to a cosmetic ill health. References regarding the drugs of' varnya dashemani' are been found in many of the Nighantus where the authors have clearly mentioned about the detail pharmacology and pharmacothereupetics. Taking these factors into consideration critical analysis of these drugs has been done. Result: After screening the pharmacology of the drugs told in this dashemani we find all these drugs are rakta prasadakara, Ojo vardhak and pitta shamak. Also recent researches have proven them to be possessing Anti Glycation, Anti oxidant, Anti microbial properties which are essential in cosmetic health and skin care. Conclusion: Hence this study has been intended to critically analyse the drugs of 'Varnya dasheman', with an aim to provide an alternative to the harmful synthetic cosmetic products.

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Purpose: Memory is combination of power of acquisition (Grahan), retention (Dharan) and recollection (Smaran). Vata, pitta, and kapha are the three psychobiological dimensions (energy) or biological rhythms regulating the entire functioning of the human body. Pitta is responsible for understanding and attaining knowledge due to its Satva, Aashukari and Tikshna property. Vata is responsible for association of ideas. Kapha provides stability which is necessary for retention of memory. Several Central Nervous System disorders (CNS) are often associated with impairment in cognitive functions. Disorders of memory can range from mild to severe. It is major health problem of 21st century. Main objective of this work is to understand the ayurvedic aspect of learning and memory mode of action of some medhya drugs W.S.R. Vacha, Shankhpushpi, Endri, Jyotishmati and brahmi. Method: A review on available scientific information in terms of references in classical texts, and Nighantus, chemical constitute, pharmacological activity is prepared with a view to understand mode of action of these Medhya dravya. Result: Pitta is responsible for understanding and attaining knowledge due to its Satva, Aashukari and Tikshna property. Vata is responsible for association of ideas. Kapha provides stability which is necessary for retention of memory. Sheetvirya and improves retention power and ushna virya drugs enhance power of acquiring new information and data interpretation. Conclusion: Ushna virya and sheet virya drugs acts through different mechanism and enhance cognition. It may provide parameters for selection of medhya drug in different memory disorder.

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Purpose: Not a single drug in Ayurveda has been termed as non-medicinal. This means every Dravya has medicinal value in this world. Jangam dravya is an animal sourced medicine. In samhita Jangam Dravya are described first. So as per Krama Varnan Vichar, Jangam Dravyas are significant in this type. In Ayurvedic literature there is more literature on Audbhid & Parthiva Dravyas. I Total available nighantu: more than 25. Total available Rasa Grantha: about 145. There is no one Grantha on Jangam Dravya which describes their whole information. Jangam Dravyas are described in Ayurvedic literature in different views and in different branches. Gross description is available in Samhitas. But they aren't in format. They are not compiled according to their Guna Karma, Upayogitwa, Vyadhiharatwa, and Kalpa etc. Their use in Chikitsa is minimal as their ready references are not available, though very much effective. So due to sheer need of compilation of these references this topic was selected for study. The basic need for study of Jangam Dravya is to prepare its whole DATABASE. So through this study Database of Jangam Dravya can be available like Jangam Dravya. Method: Selection of topic this is a fundamental & literary study, Selection of material, Selection of Database software & font, Collection of data & preparation of Master Chart, Preparation of Database, Interpretation & summarization of data. Result: So in this paper, we are going to focus on literature availability of jangam dravya with the help of modern technique like Microsoft Excel. And also how we can prepare and use the categorical interpretation of jangam dravya with help of database Conclusion: Jangam Dravyas are described in Ayurvedic literature in different views and in different branches. Importances of these dravyas are the main key point of this study.

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Purpose: APAKARSHAN CHIKITSA SIDDHANT: 'Punarapi Apakarshan' Ashtang Sangrah 12/6; 'Apakarshan......' Charak Viman 7/28. Vyanga Vyadhi Described under Kshudra Roga in various Samhita`s. The objective is To study the sign & symptoms of Vyanga. To study the efficacy of Triphala Kwatha on vyanga under the siddhant Apakarshana chikitsa. Method: 30 patient were taken govt. Ayurved College, Nagpur, Dravyaguna OPD. Drug Triphala Kwatha for Virechanartha. Dose decided as per mrudu, madhyam, krura kostha. Duration: 1 to 2 months. Criteria of Assessment 30 patients were taken and chloasma was measured & scored (4 0) before treatment and after (1 &2 months) treatment. This data is presented in table. Following gradation were decided: 4 Very Severe dark circle; 3 Severe dark circle; 2 Moderate dark circle; 1 Mild dark circle; 0 Relived dark circle. The data is completely non parametric in nature and symptom severity is a desecrate variable. For coloration distribution is polynomial and so Wilcoxon Signed Rank Test was applied which is equivalent to paired "t test" of parametric analysis. Result: Details of statistical analysis of our data is presented below. Vyanga dark circle. Total score of Lakshana before starting the treatment = 89. After first Virechan Karma the total Lakshana score = 89 (0%). After Second Virechan Karma the total Lakshana score = 61(31.46%). After 7 days of second Virechan Karma the total Lakshana score = 61(31.46%) Mean observed second virechan karama as well as 7 days after second virechana karama = 2.0333. The S.D. of this data = 0.8087. Z= 5.112b. P. Value of this data (p < 0.05) Conclusion: The data shows significant (p < o.05); After Triphala Kwatha Virechan within 1 months p > 0.05; Triphala Kwatha Virechan after 2 month p < 0.05; Significant result found after 2 month.

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Purpose: A report, prepared by WHO and the World Economic Forum says that India will incur an accumulated loss of $236.6 billion by 2015 on account of unhealthy lifestyles and faulty diet. The WHO and International Obesity Task Force have declared the obesity epidemic on a global scale. Though genetic factors contribute to human obesity, the nature of diet plays a key role in Medoroga. Ayurveda has given top priority to food under the three supporters of life. Among them, Yava (Hordeum vulgare) is a supplementary diet for which wide references were found in classics as preventive and curative aspects of medoroga. Keeping this in view the present study has been taken up to evaluate the efficacy of yava in medoroga. Method: 30 clinically diagnosed cases of Medoroga were selected from O.P.D of S.V. Ayurvedic hospital, Tirupati following specific exclusion and inclusion criteria. Diagnostic criteria including laboratory investigations along with subjective and objective parameters were considered for the study. Dose Yava churna 10 gm BD with hot water. Duration 90 days. Result: Statistical data revealed highly significant reduction in serum cholesterol, Body weight, MI, serum triglycerides, VLDL and significant improvement in HDL levels. Conclusion: Administration of yava churna has given better results. It was evident by the significant changes in the subjective and objective parameters.

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Purpose: Urinary stones have occupied a major place in the urological practices. It is one of the most common and painful urologic disorder of the urinary tract. Generally, the age between 20 to 40 years is more prone to it. As it has a high rate of recurrence, it is affecting economy and general health of the people Method: This study was a prospective, placebo controlled, double blind study. The study incorporated a matched pairs design. Each patient has received a single treatment of either the control or investigational product (UNEX). The goal was to enrol approximately 80 patients in order of having 60 patients (30 in each group) to complete the trial and provide data for analysis. Result: Total 72 patients were enrolled in the study, out of which 64 patients completed There was extremely significant results obtained in case of urine analysis of patients for infection, bacteriuria and haematuria, at the end of 6 months, value as compared to before treatment value the study, With the treatment with UNEX capsule, significant relief was observed in case of X ray KUB shows that renal calculi disappeared in 18 patients at the end of 6 months out of 32 patients, whereas USG of renal pelvis shows disappearance in 16 patients out of 32, which is extremely significant as compared to before treatment value where 32 patients showed presence of renal calculi. However, in placebo, only three patients out of 32 showed absence of renal calculi at the end of 6 months of treatment. Conclusion: Considering the excellent results of the clinical trial, it can be concluded that UNEX is effective in the treatment of Ureteric calculi, without producing any undesirable side effects. No clinically significant adverse reactions were reported or observed, the clinical trial of UNEX, an Ayurvedic preparation, has proved its efficacy and safety in upper ureteric calculi.

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Purpose: Mood disorder is more common than any psychiatric illness except the organic syndromes. General population is susceptible to an 8 25% or more incidences of major depression as a life time risk. The highest rate of suicide occurs in depression, making this form of psychiatric illness particularly dangerous. Method: Various researches involving Panchakarma therapy as the mainstay of the treatment have been conducted throughout the country in different institutes. In this work, researches conducted on Manoavsada with Panchakarma as the line of treatment in the past few years were taken. These works were conducted at National Institute of Ayurveda, Jaipur and I.P.G.T.R.A, Jamnagar. The results were derived from these research works involving various assessment parameters. Result: Panchakarma therapy has played a major role in providing cure to such patients in any stage of mood disorder. Conclusion: Panchakarma has provided an efficient answer to the depressive disorders in an effective and long lasting manner as compared to the other modes of treatments practiced worldwide.

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Purpose: Proper care must be taken even for a clean wound in normal body to heal earlier with a minimum scar. Various scientific and technological advancement taking place from time to time the problem wound healing is still under evolution process, till now there are many research works have been undertaken on Chronic wounds. As Dustavrana is vitiated by various doshas so it needs proper care in proper time. Hence in present concept all efforts are directed to keep the wound clean and also to enhance the wound healing. To manage the Dustavrana different type of treatment modalities explained in the classics, Bala Taila is one among them. Objective of study: To assess the effectiveness of BalaTaila Application in wound healing. To assess the healing of wound (Vrana ropana). Method: 30 patients were selected according to inclusion criteria and divided into two groups of 15 each. Viz Group I: Trail group, were treated by Bala Taila local application once daily & Group II: Control group, were treated by the application of Hydrogen Peroxyde, sterile dry gauze were used for dressing. Result: Results were assessed with the help of prefixed assessment criteria, and favorable results obtained on, Vedana as 85%, Swelling 80%, Varna 84.44%, Srava 82.92% Granulation 86.66% and size of wound 79.41%. The result of Bala Taila is found to be statically significant in the process of wound healing Conclusion: The Bala Taila proves a vital role in the healing of Dustavrana.

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Purpose: Rasamanikya a very famous preparation with different pharmaceutical methods used in various diseases since long, but in todays modern era it requires toxicological updating to understand the drug by carrying out animal experimentation so as to provide scientific data and statistical validation for its safe and efficacious action. The main intention of conducting this study was to find out and understand various toxic effects produced by the drug Rasamanikya in the present era when it is prepared with three different procedures though with the same drug Haratala (Orpiment). Method: Toxicological study of Rasamanikya prepared by three methods was subjected on Wistar stain albino rats for acute toxicity study by taking up and down/staircase method and sub acute toxicity study by giving ten times that of the therapeutic dose. After 21 days duration of drug schedule albino rats from each group were anesthetized and sacrificed. Liver function test was assessed and the tissues of Kidney, Liver and Brain were subjected for Histopathological study. Result: The LFT report revealed in all the three groups there was mild increase in the SGOT, ALP and Tot. Bilirubin values respectively with statistical significant result indicative of mild liver dysfunction and bile duct injury which may be correlated with the mild fatty changes of liver cells. Histopathological reports showed minor toxic effects but with no any remarkable damage to Brain, Liver & Kidney and overall findings were suggestive of normal appearance. Conclusion: Acute and Sub Acute study showed no immediate and evident toxic signs and mortality. Rasamanikya prepared with adopted method showed mild toxicity but with an attempt of healing and repair. Histopathological and LFT study showed mild to moderate fatty changes which were statistically significant. Overall these toxic effects of mild to moderate changes in rat cells with correspondence to human cells may be considered as non specific and reversible.

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Purpose: Adult hood attained with paradogmic shift in life style and its own stress leading to birth of many ailments of chronic nature. Hypertension and obesity considered to trigger many fatal diseases. Yoga can be implemented as non pharmacological intervention in these problems. So to evaluate effect of yoga during short term yoga program on semi urban school teachers was carried out. Objectives: To assess effect of yoga techniques on body weight, systolic and diastolic blood pressure during short term practice. Method: 55 Semi urban school teachers between age group 20 to 55 years were subjected to one week Yoga program. Yoga training was given for 2 hrs from 6am to 8am. Yoga session included ASANAS and PRANAYAM, QUICK RELAXATION TECHNIQUE (Q.R.T). Weight, Blood Pressure was recorded before yoga session on first day and on last day after yoga performance. The results were statistically analyzed. Result: During the study, significant result in Weight with t value 2.506 and Systolic Blood pressure with t value 2.214 at P>0.05. But no significant result in Diastolic Blood pressure was observed at P>0.05 with t value 0.413. Discussion: Asana like Surya Namaskara, Ardha kati chakrasana, Paada Hastasana etc may regulate lipid metabolism, calorie expenditure by muscles and soft tissue and also reduced fat accumulation may attributed to Weight reduction. Significant Drop in both systolic and diastolic blood pressure was may be due to Pranayama and Quick Relaxation Technique which helped in reducing stress and increase mental relaxation. Conclusion: 1. Even short term yoga practice has its beneficial effect on weight and blood pressure. 2. Hence yoga therapy can be considered as potential alternative approach for the management of weight and blood pressure.

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Purpose: A new approach for Prakruti Assessment By Gradation method Method: In Ayurveda, Charakacharya described Prakruti according to Gunas. Guruwadi twenty Gunas are also helpful in Chikitsa. Out of these 20 Gunas: Guru, Laghu, Shita, Ushna, Ruksha and Snigdha are more dominant in 6 Rasas; and these 6 Rasas plays an important role in Chikitsa and maintenance of Prakruti. Prakruti is formed by dominance of Dosha Gunas and diet taken by mother and her activity. The diet is composed of 6 types of Rasadravyas. The 6 Rasas are formed from the above 6 Gunas. Hence the Lakshanas due to these 6 Gunas has been given more importance in theassessment of Prakruti by gradation method. Gradation method: Lakshanas of the Prakruti were classified into two groups: 1. Lakshana due above six Gunas were given 2 marks, 2. Lakshana due to all other Gunas were given 1 mark. Result: In Vata Prakruti: Lakshanas due to Ruksha, Laghu, and Shita Gunas were given 2 marks and others were given 1 mark. In Pitta Prakruti: Lakshanas due to Ushna, Laghu and Katu Gunas were given 2 marks and others were given 1 mark. In Kapha Prakruti: Lakshanas due to Snigdha, Shita, and Guru Gunas were given 2 marks and others were given 1 mark. Conclusion: By Gradation method, Prakruti is assessed not only by Dosha but predominance of Gunas of an Individual Dosha. It is useful if there is predominance of same Dosha by percentage method. This helps to study Prakruti statistically.

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Purpose: Conceptual & clinical study on Psoriasis according to Ayurveda as well as Modern science on various scientific parameters, Clinical evaluation of efficacy of Vamana, Virechana & Laghumanjisthadi Ghana in Management of Psoriasis, and comparative clinical study of trial drug along with standard allopathic regimen. Method: Selection of patient: The study was conducted on 30 clinically diagnosed & confirmed cases of Psoriasis. Criteria of diagnosis: The main criteria of diagnosis of patients were based on the cardinal and associated signs and symptoms of the disease based on the Ayurvedic and modern texts. These have been depicted in detail in the criteria of inclusion. Criteria of inclusion: 1. Patients who are willing for trial, 2. Patients in the age group of 15 - 60 years, 3. Patients of Mandal Kustha diagnosed by Ayurvedic classics and psoriasis diagnosed by Modern classics. Exclusion criteria: 1. Patients with age below 15 & above 60 yrs, 2. Pregnant women's & lactating mothers, 3. Patients suffering from serious systemic disorders like Diabetes Mellitus, Cardiac & Renal Disorders, Malignant disease, Major liver disorders etc., 4. Patients Contraindicated for Vaman & Virechana as per classical Ayurvedic Texts. Result: Significant results were obtained in PASI Score, Itching & Burning Score. Conclusion: So it is concluded from above study that Vaman, Virechana followed by administration of Laghu Manjisthadi Ghana is effective in management of Psoriasis as it is safe, cost effective & free from any side effects. It also prevents the relapse considerably.

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Purpose: Chronic wounds are a challenge to the modern medical science since there is no proper medication to correct this imbalance as to stimulate and enhance the growth of healthy granulation tissue making the wound fill up. When Sri Lankan traditional medicine is concerned it has been strewn with a large number of medicinal formulas for wound healing especially for granulation tissue formation. The primary intention of this study was to collect these formulas and analyse them to come up with the most frequently used herbal, mineral and animal material. It was also wished to analyse their pharmacodynamics properties to see how they agree with Ayurvedic theories in healing a wound. Method: For this purpose, a literature study was carried out by referring 30 major Sri Lankan Traditional texts and manuscripts. Formulas which particularly prescribed for tissue formation (Vrana ropana) were retrieved. They were studied, analysed and were calculated to come up with the mostly used ingredients. Result: At the end of the study 152 formulas were analysed gathering 157 herbal material, 10 minerals and 8 materials of animal origin i.e. 176 materials in total. The analysis revealed that Ficus religiosa, Ridi thuththam (Calamine) and Bee's wax as the most frequently mentioned material in wound healing formulae in Sri Lankan traditional medical texts. Pharmacodynamic analysis showed essential properties in nutrition and growth. Conclusion: It was seen that the Sri Lankan Traditional Medicine possesses a rich pool of medicinal formulas for chronic wound healing. Ficus religiosa, Ridi thuththam (Calamine) and Bee's wax as the most frequently used materials with herbal, mineral and animal origin respectively in wound healing formulae in Sri Lankan traditional medical texts.

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Purpose: The disease Amavata can be presented as very similar to Rheumatoid Arthritis. Rheumatoid Arthritis is chronic in nature and affects mostly middle aged people. For this disease there is no satisfactory medicine is available till date. But in Ayurveda there are many drugs described for Amavata which are cost effective and easily available with no side effects. The present clinical study evaluated the effect of Chitrakadi Churna and Kshar Basti in the management of Amavata. Method: 30 clinically diagnosed patient of Amavata were registered and completed the trial. In this 15 patients (Group A) administered Chitrakadi Churna 4gm twice daily with lukewarm water after meal. Another 15 patients (Group B) administered Chitrakadi Churna 4gm twice daily with lukewarm water after meal and Kshar Basti as per Kalbasti krama i.e 16days followed by local Snehan Swedan. Result: Results of this trial were encouraging as there is improvement in each symptom of patient like pain, stiffness, swelling, and tenderness. Group A in which only Chitrakadi Churna was administered there was no significant improvement seen statistically. But Group B in which Chitrakadi Churna as well as Kshar Basti was administered highly significant improvement seen statistically. Details of the Statistical test and other important will be discussed at the time of paper presentation. Conclusion: From present clinical trial it is concluded that this therapy is very useful for pain, swelling, tenderness and stiffness, which were chief complaint of the patient. Chronicity more than 3 years did not show marked improvement. And also this drug is supposed to be very good combination of Vedanashamaka, Shothaghna, Amapachaka Dravyas. No untoward effects were seen except mild loss of weight.

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Purpose: Alternative treatment through direct intervention at the frequency level using principles of ayurved and technological understanding of ayurveda with quantum physics. Method: Each and every particle in the universe is in a state of constant movement in the form of vibrations occurring at a particular frequency. Similarly in the body, these vibrations occur. Each and every tissue in the body has its own set of frequencies which helps it differentiate itself from the other tissues in the body structurally and functionally. Any imbalance in this results in the change of state of the 3 major categories of reactions found in the cell anabolism, catabolism and transformation which ultimately results in formation of diseases. Result: Treating these imbalances of frequency in the correct way by increasing or decreasing any of the 3 processes and tapping into the body by various routes to make this happen is the basic principle of ayurveda. To avoid these routes and mediums like herbs, metals, mantras, etc, direct supply of the corrected frequencies in the channels or the meridian field of the body can correct any such abnormalities instead, whilst serving purposes of widening channels and breaking open blockages of such channels, the aim of healing is to get rid of this imbalance. Conclusion: Hence, we see that when treatment is given on the most fundamental level of existence, it affects us much more directly, effectively, affordably and repeatedly with theoretically no side effect. This must be taken up and spread for the betterment of humanity.

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Purpose: Contamination, deterioration and variation in composition problem of herbal medicines can be resolved by developing physico chemical fingerprints for the standardization of the drugs and comparing them with the reference authentic drugs, variation between preparations from different companies and by evaluating batch-to-batch changes during long term storage. Method: In present context we had standardized the ayurvedic preparation Eladi vati by using chemical markers. This vati and individual herbs had been evaluated for various physicochemical parameters, in process evaluation parameters, TLC (as identification of active principles), quantitative determination of marker compounds by HPLC method, determination of microbial contamination and toxic heavy metals by Atomic Absorption Spectrophotometer. The piperine, gallic acid and glycyrrhizic acid were quantitatively determined. Result: The results obtained with individual herbs had been compared with standards and results obtained with formulation had been compared with the other similar vati formulations available in the market. The results are almost alike in the Piperine, Glycyrrhizic acid and Gallic acid content. The concentration of heavy metals and microbial contamination were found under limit in ppm and colony forming units per gm respectively. Conclusion: The method can be suggested for effective quality control of herbal products and will establish standardization parameters for identification, quantification and purity determinations.

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Purpose: Withania somnifera (L) Dunal is a perennial shrub from the Solanaceae family and well known medicinal plant. Traditionally it is known as Aswgaandha. The root extract has been traditionally used as a tonic and as a sedative but recent research shows that the leaf extract contains Withanolides which have been found to have regenerative properties on brain cell synapses in human cell lines in laboratory studies. Withania somnifera seeds are harvested in the month of March, April. Seed storage under ambient conditions is a very problematic due to prevailing high humidity and atmospheric temperature. If seeds stored under uncontrolled conditions, the viability may go down below ten percent after monsoon. So to maintain the vigour and viability of Withania somnifera seed during storage was essential for ensuring better crop stand. Method: Withania somnifera seed were dry dressed with finely powdered pharmaceutical formulations (aspirin, active ingredient ortho acetylesalicylic acid @ 100 mg / kg of seed; celin, active ingredient ascorbic acid @ 500 mg / kg of seed), chemicals (common bleaching powder, active ingredient calcium hypochlorite @ 2 g / kg of seed) and crude plant materials (finely powdered dried fruit of Capsicum frutescens (red chilli powder) and Catharanthus roseous leaf powder @ 2 g / kg of seed). After treatments germination test were carried out by standards germination test method and seed vigour also studied by the measurement of root and shoot length. Result: Seed deterioration was very fast after monsoon months in uncontrolled storage. More or less all dry dressing treatments significantly slowed down seed deterioration in comparison to untreated control under subsequent storage conditions. Conclusion: The result indicates that pre storage dry dressing treatments of Withania somnifera seed with aspirin and red chilli powder are suggested for the maintenance of seed viability during storage period and they are inexpensive.

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Purpose: Adolescence is a period of rapid physical, emotional, cognitive, social growth and development. Though menstrual education programs are conducted in schools, the factual information that adolescent girls need is not always available to them leaving behind a large number of unanswered questions, ranged from sophisticated to poignantly ignorant, in the minds of young girls. Method: 1,430 female Indian students from middle and lower socioeconomic class, ranging in age from 12 to 15 years of a Pune city school were given a chance to ask anonymous written questions after the menstrual health and hygiene classes. Result: The most popular categories of questions were on menstrual physiology; beauty and symptoms associated with menstruation, followed by myths and taboos, use of sanitary pads, anatomy of reproductive organs, diet and menstrual disorders. Among 258 questions asked voluntarily, the most popular topic for 6th graders was menstrual physiology (45%) and beauty for 7th (39%) and 8th (19%) graders. Why does baby grow in mother's womb only, how do astronauts get menses in space, do boys too develop pubic hair, does a girl become pregnant immediately after menarche, etc. were some of the interesting questions showing the curiosity and ignorance in the minds of young girls. Myths and taboos like during menses a girl shouldn't enter kitchen, perform religious activities and touch others, getting infertility if disposed sanitary pad is sniffed by a snake etc. were persistent. The significant increase in the questions under beauty category from 2% (6th grades) to 39% (7th grades) depicts sudden increase in level of self-consciousness and attraction towards opposite sex. Conclusion: Questions asked by local adolescent girls should be considered by physicians and health education policy makers as the bases for designing subsequent material and programs on menstrual health education.

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Purpose: Now a day's occurrence & recurrence of Ashmara (Renal Calculus) are very common & its rate of incidence is alarmingly increasing. Some acute cases require immediate attention to relieve from severe pain. Even surgery is recommended if a calculus is larger in size because it can cause many complications. Conservative line of treatment is recommended if calculi are small in size, non obstructive, post operative and in the cases of recurrence. For the conservative treatment of Renal Calculi, Ayurvedic medicines are being used successfully since centuries for removing the calculi in addition to protecting its formation. Method: This study was conducted in the Department of Ayurveda, Indira Gandhi E.S.I. Hospital, and Delhi. The patients were selected irrespective of their age, sex, occupation etc. in the Ayurvedic OPD and treated with classical as well as some patent & proprietary Ayurvedic medicines for the minimum period of two months according to type of calculus along with associated signs & symptoms. Result: Since December 2009 to September 2011, total 500 patients were registered. Out of them only 400 cases were selected for this retrospective study that completed minimum course of two months. In most of the cases severity & episodes of pain markedly reduced, number and size of calculi, hydronephrosis (mild to mod), burning micturition, nausea & vomiting etc. also shown decreasing pattern and 90 cases were completely cured. Conclusion: Ayurvedic medicines are highly effective in the treatment of Ashmara, which shows their Lithotripsic action.

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Purpose: In this research work, an effort was made to observe effects of Samanya Shodhanottara Vishesha Shodhana and only Vishesha Shodhana upon Tamra. Method: Methods described in Rasatangini were followed to perform Samanya as well as Vishesha Shodhana. The study was carried out in two parts. In first part, actual process of Shodhana by various methods was performed and six samples were prepared. In second part, analysis of Ashodhita and Shodhita Taamra (Samanya Shodhanottara Vishesha Shodhit as well as only Vishesh Shodhita) was carried out. For this purpose, following parameters of analysis were considered- Change in physical characteristics of copper foils pre and post Shodhana, Change in weight of copper foils pre and post Shodhana, Pattern of XRPD for each sample, Percentage of copper in each sample by ICP AES, Change in electrical conductivity of each sample. Result: After Samanya Shodhana, the previous shine of copper was totally lost and it had crumpled appearance. Overall, Changes in tenacity of metal were also observed. The hardness went on decreasing and brittleness went on increasing. Steady fall in weight of Tamra was observed after each Shodhana. The XRPD samples of all the samples of Shodhita Tamra showed presence of copper and copper oxides in them. However, the peak positions and intensities of them were varying. There was marked decline in electrical conductivity post Shodhana. Conclusion: It appeared from this study that Vishesha Shodhana of metals if preceded by their Samanya Shodhana produces better results. This time tested exercise certainly brings about significant changes in metallic properties of metals. Performing only Vishesha Shodhana or only Samanya Shodhana is not adequate.

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Purpose: Hemiplegia is a prevalent and disabling neurological disorder, which arises from multiple etiologies like Systemic Hypertension, Injuries, Tumors, Embolism and other vascular occlusions of the brain. It is well explained in Ayurveda as Pakshaghata one of the kevala vata vyadhis, resulting when Vatakopa affects the Siras (vascular structures) and Snayus (Tendons and Ligaments ) of any one half of the body characterized by paralysis of the affected half of the body, face and impaired movements of joints and extremities. In modern science, the lesion and clinical symptoms stands classified in accordance with the site of infarction of the brain. Hemiplegia Pakshaghata however today, currently challenges the clinicians warranting a comprehensive and effective medication. Ayurvedic polyherbal formulations have been found to have therapeutic efficacy for Hemiplegia. This study aims to determine the clinical efficacy of Danadanayanadi Kasayam, Ksheerabala Avarthi and Ekangavir Ras towards restoring the normalcy in Pakshaghata. Method: 15 patients in the age group of 30 70 with Pakshaghata were randomly selected and administered Danadanayanadi Kasayam, Ksheerabala Avarthi and Ekangavir Ras for a period of 6 - 8 weeks. The clinical progress of the patients was observed daily. The gradual recovery from the clinical symptoms was observed and documented. Result: The patients administered with the trial drugs portrayed a marked recovery from the inability to move the arms and legs, stiffness, incoherent speech, deviation of mouth, hyperreflexia, poor concentration, confusions and impaired functions of the sensory organs. Conclusion: It is extrapolated and fortified from the observations that Ayurvedic polyherbal formulations viz. Danadanayanadi Kasayam, Ksheerabala Avarthi and Ekangavir Ras undoubtedly has the efficacy of treating Hemiplegia and helps in the recovery from ailment.

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Objective: To assess the safety and efficacy of traditional herbal medicine preparation in HIV 1 positive patients. Material & Methods: The efficacy of a combination of three herbal drug preparations in a total of 10 HIV 1 positive patients attending our herbal clinic at Hanumantgaon was assessed. Eight patients have only on herbal formulations, while the other two had ARV treatment along with herbal formulations. The patients were tested for their HIV status by standard NACO protocols and CD4 and viral load estimate followed along with the other clinical and biochemical analysis. Results: The duration of the 10 patients for herbal treatment ranged from 11months to 65 months follow up. Except for the patients on 11 months the overall gain for CD4/CD8 was increased. Eight patients out of the ten patients showed viral load below detection level after the traditional herbal formulation treatment while the other two showed a reduction. One patient among eight patients who on herbal treatment had tuberculosis from seven months before and was on anti-tuberculosis treatment along with herbal treatment got reduced to below detection level from59304 copies/ml. Though only 2 patients were on ARV treatment was involved they had no side effects with herbal formulations. All the 10 patients on herbal treatment showed improvement in health and well-being. Conclusion: The primary conclusion is that traditional herbal preparations can be used as an alternative form of therapy in HIV positive individuals.

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'Ksharsutra' can be defined as an Ayurvedic medicated thread (Cutting Seton) coated with herbal alkaline drugs. 'Ksharasutra therapy' has been described as a treatment of choice for the treatment of fistula in ano due to low recurrence rate (up to 3%). However, this unique para surgical procedure is not yet globally accepted basically due to lack of standardization in the Ksharsutra preparation process and poor acceptability by Modern surgeons due to lack of training& fear of Complications. Need for Standardization of Ksharsutra: Standardization of 'Ksharsutra' requires standardization in preparation process and quality standards including packaging, storage, labeling and developing scientific parameters for maintaining its uniform coating, pH, microbial check etc. What is 'ADR Ksharsutra Kit'?'ADR Ksharsutra Kit' is a disposable 'Ksharsutra Applicator' made up of HDPE. This Ksharsutra embedded device after UV treatment is kept in Airtight silver foil sachet.The Physico chemical Characters of Ksharsutra, its indication, manufacturing details along with its expiry date, etc. are labeled properly. Method of 'ADR Ksharsutra' Application: The tip of the 'ADR Ksharsutra Applicator' is introduced in the external opening and allowed to follow the track upto the internal opening situated in the anal canal. Once the tip comes out through the internal opening, cap is removed and the Ksharsutra is firmly held with artery forceps. After this, applicator' is withdrawn (taken back) from outside opening. By doing this, the embedded Ksharsutra is automatically placed in the fistula track whose two ends are tied together. 'ADR Ksharsutra' has truly made the entire procedure very smooth and will be helpful in Globalization of Ksharsutra technique for fistula ablation & acceptable to modern surgeons.

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Purpose: Sheetaprabha tablets, Ayurvedic proprietary medicine, contain Sweta Parpati & Hajrul hahood bhasma as active ingredients. Sweta parpati is mainly indicated in mootravaha srotovikara & hajrul hahood bhasma is having mootrala and ashmari bhedana actions. A survey of the literature showed that no pharmacology study was made on the sweta parpati and sheetaprabha tablets. In the present study we investigated the effect of Sheetaprabha tablets in ethylene glycol induced urolithiasis in rats. Method: Urolithiasis was induced in male wistar rats by adding ethylene glycol (0.75%) in drinking water. Protective (130mg/kg & 260mg/kg) and curative effect (130mg/kg & 260mg/kg) of Sheetaprabha was studied in experimental animal models. Result: Ethylene glycol induced urolithiatic rats showed significant increase in blood urea nitrogen (P<0.001), creatinine & phosphorus (P<0.05) and also significant increase in SGOT, SGPT & ALP levels in serum, which were prevented by Sheetaprabha treated rats in protective groups and decreased in curative groups. Histopathologies of kidneys were prevented calcium oxalate formation and tubular degeneration, and increase in tubular regeneration was observed in protective (130mg/kg, 260mg/kg) group. Conclusion: The present study findings indicate that treatment with Sheetaprabha tablets, which decreases and also prevents the growth of the calcium oxalate crystals in urinary tract. It also seems that the preventive effect is more effective than its curative effect. Hence, this study confirms the traditional use of Sheetaprabha tablets in urolithiasis.

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Purpose: In Ayurveda although there is no such terminology like hypertension but still this work is an approach to establish relationship between Hypertension & vitiated functioning of three governing forces of our body i.e. Tridosha and to treat Hypertension on Ayurvedic principles. The logic behind such correlation is based on the fact that, like other physiological processes, B.P. too is normal phenomenon of our body which is governed by Tridosha. After going through modern pathogenesis of primary hypertension and its symptomology, in present study it has been correlated with Vata Kaphaja Vikara with Rasavaha, Raktavaha and Manovahi Srotas as the seat of disease. Looking at its pathogenesis, the term Uccha Vyan Bala (exaggerated physiological functioning of Vyan Vayu leading to increase contractility of heart & blood vessels) can be coined for hypertension. Method: Subjective criteria Headache, Palpitation, Vertigo, Dyspnoea on walks and Fatigue. Objective criteria BP value recorded by sphygmomanometer in supine position. Final assessment of results; Subjective assessment 75 to 100% disappearance of symptoms effectively cured. 50 to 74% disappearance of symptoms well cured. 25 to 49% disappearance of symptoms fairly cured. 0 to 24% disappearance of symptoms poorly cured. Objective assessment Patient showing reduction in BP by 10mmHg Poorly cured; Patient showing reduction in BP between 11 to 20mmHg Fairly cured; Patient showing reduction in BP between 21 to 30 mmHg Well cured; Patient showing reduction in BP by more than 30 mmHg Effectively cured. Research methodology Type of study-Single blinded comparative study. Study site IPD and OPD department of Shubhdeep ayurved medical college, Indore (MP). Sample size 50 patients divided randomly into two equal groups. Group A given trial drug whereas Group B given control drug. Drug dosage and vehicle 1 capsule twice daily with lukewarm water after meals. Duration of treatment one month (examined at weekly intervals.) Dietary advice to strictly restrict the daily intake of Amla, Lavana, Guru & Vidahi diet. Result: 70% Patients found to be hypertensive were above 40 years of age. 60% Patients were fond of salty & spicy diet. Out of 50 patients 30 patients (60%) belongs to service class. Out of 50 patients 35 patients (70%) were male. Regarding prevalence of symptoms, Dyspnoea on routine work was found in 82%, Headache & palpitation in 80%, Vertigo in 78% & Fatigue in 66% patients. Conclusion: As per classical texts, Vata predominant diseases are caused due to vitiation of Vata due to emaciation (Dhatu Kshaya) & obstruction (Marg avarodha). Hypertension seems to be Vata predominant disease due to obstruction. Reason being that, Lavana is Vata Shamak, & should therefore decrease Blood pressure but on contrary it increases B.P. Similarly increase in weight leads to greater chances of High Blood pressure. Above discussion favours that Hypertension can be considered Vata predominant disease due to Marg avarodha by Kapha Dosha and Pitta Dosha in Anubandh. Finally it can be concluded that the drug under study has shown enthusiastic results in reducing the overall value of blood pressure. 64% patients got effectively cured, 24% got well cured and 12% got fairly cured. Regarding symptomatic relief, out of 25 patients 8 showed more than 75% relief, 9 showed more than 50% relief, 7 showed more than 25% relief and only 1 patient showed less than 25% relief in overall symptoms. No significant side effects have been reported in any subject.

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Purpose: Though both, nonsurgical and surgical treatments are in practice for the management of erectile dysfunction in allopathic system, but each of them is having its own limitations and demerits. The nonsurgical treatment are having poor efficacy with systemic and local side effects. The surgical treatments are associated with complications, change in the shape of the penis and they are unaffordable by the common people. Method: Patient is selected as per the classical signs and symptoms of Klaibya. Phala Ghrita is used for the Uttarabasti in the dose of 30 ml for each episode. Uttarabasti is given in two divided courses as: 4 consecutive days in the 1st course followed by 4 days of rest; and again 4 consecutive days of Uttarabasti. The criterion for assessment of results is based on the scoring of International Index of Erectile Function (IIEF). Result: Uttarabasti with Phala Ghrita has shown encouraging results on Erectile Dysfunction as well as Seminal parameters. Photos & videos of the procedures carried out by me will be discussed and shown during my full paper presentation. Conclusion: Hence Uttarabasti is an effective, safe and affordable therapy to manage this troublesome problem

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Purpose: The desire to have a healthy progeny is innate & very intense in every living being. The hectic life and tremendous stress in today's world has made the conception & continuation of pregnancy to term very difficult. Anaemia is one of the common disease conditions which affect a pregnant woman. In Ayurvedic classics anaemia in pregnancy is taken under the Rasa Pradoshaja Vikara. It is also a Santharpanotha Vikara. Method: Total 26 patients were registered from O.P.D. And I.P.D. of the department of Streeroga & Prasootitantra, out of them 4 patients were discontinued. They were randomly divided in to two groups; Group A (n 12) Pandughni Vati 2 tablets of 250mg tds and Group B (n 10) Dhatri Lauha Vati 1 tablet of 250mg tds. Dhatri Lauha Vati was selected for the present study due to its Pandughna, Prinana, Raktaprasadana properties. AYUSH department has developed a compound formulation Pandughni Vati. As a part of its clinical trials the same drug was selected for present study. Result: Group A The result observed in Shwasa (dyspnoea) (60%) and Hridrava (palpitation) (53.33%) were highly significant statistically (<0.001). Daurbalya (33.33%), Shrama (fatigue) (40%), Aruchi (anorexia) (28.57%) and Pindikodvestana (55.55%) were decreased significant statistically (<0.05) whereas in Panduta (pallor) (24%) it was not significant. In Group B, results observed were highly significant statistically (<0.001) in Panduta (pallor) (50%) and Shwasa (dyspnoea) (56.25%). The results in Shrama (fatigue) (61.54%), Hridrava (palpitation) (55.55%), Aruchi (anorexia) (42.85%), Pindikodvestan, (49.49%) were significant Conclusion: On comparing the effect of therapy study was finding better percentage improvement in-group B consistently in most of subjective and objective parameters. So it can be said that Dhatri Lauha Vati has somewhatbetter results, proving it better to Pandughni Vati.

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Purpose: The sandhigata vata described in Ayurveda causes the symptomatology such as shula, sotha, stambhana, sparsha asahyata, sputana, akunchana prasarana vedana etc. whereas the osteoarthritis described in modern science can be correlated with sandhigata vata because it also produces the features such as inflammation, pain, stiffness, limited movements and deformity in severe cases. Osteoarthritis is the 2nd most common illness with 22 29% of prevalence in global population. Presently available modern medication is causing many side and toxic effects which sometimes may need hospitalization also. Hence it requires the need to find such a therapy which gives better relief without any side or toxic effects and also natural, cost effective and easily available. Hence the non surgical biological therapeutic means such jalaukawacharana was selected, Method: Total of 20 patients were selected on the basis of selection criteria (inclusion and exclusion criteria) and then they are grouped into two i.e. 10 each in Jalukawacharana and Yogaraja guggulu group. The jalukawacharana was done with 7 day interval for about 6 sittings in 1st group where as in 2nd group yogaraja guggulu 125mg thrice a day was given for 6 weeks. For assessment, the Koos was taken as subjective and range of motion was teken as objective parameter for proper assessment and they are subjected for statistical validity. Result: After analyzing, the jalukawacharana shown significant and remarkable result in comparison with Yogaraja guguulu. The symptomatology was reduced to great extent and range of motion is also improved a lot by jalukawacharana than with yogaraja guggulu. Conclusion: the janu sandhi gata vata can correlate or compared with osteoarthritis of knee joint. The non surgical, biological therapeutic means i.e. jalukawacharana shown good result in treating with janu sandhigata vata i.e. osteoarthritis of knee joint in comparison with standard group i.e. yogaraja guggulu.

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Purpose: Study is part of an ongoing reverse pharmacology approach in new drug develpement for diabetes. It was designed to determine anti diabetic potential of DB 14201 in streptozotocininduced Type I Diabetic rats in a GLP compliant setting. Method: Male wistar rats of 8 10 weeks and weighing 180 230 gm were used. After acclimatization, streptozotocin was administered by intravenous bolus injection. Stabilization period of 14 days followed screening with Glucose Tolerance Test. 24 rats with fasting glucose > 130mg/dl during the GTT profile were considered as diabetic and randomized into 3 groups. 8 untreated wistar rats were considered as non diabetic controls. Group I, the Non diabetic control group received sterile deionized water in equivalent volumes to the treatment. Group II, Hyperglycemic vehicle control group, received Streptozotocin and sterile deionized water in equivalent volumes to the treatment dose. Group III, the Hyperglycemic rats receiving DB14201 250mg/kg/day, and Group IV, the Hyperglycemic rats receiving DB14201 500mg/kg/day, also received Streptozotocin. Observations comprised of mortality, general cage side and clinical observations, and weekly blood glucose estimation. Biochemical parameters estimated on day 1 and day 15 were Serum Insulin Levels, Serum Triglycerides, Total Cholesterol Levels, Serum Urea, Serum Creatinine, SGPT levels, SGOT levels, Hepatic glycogen content, Polyuria, Polydipsia, Polyphagia, Diarrhea and , Body weight. Result: After 14 days of continuous treatment with DB 14201 in 500mg/kg treatment group, the blood glucose levels decreased by 85.24% showing a significant (P<0.01) anti hyperglycemic potential of the test item with reference to the hyperglycemic control animals. While a decline in blood glucose levels of animals treated with 250mg/kg of the test item was observed, this was not found to be statistically significant. Conclusion: The study clearly demonstrates that DB14201 is able to effectively bring down blood sugar levels in hyperglycemic rats after 14 days continuous oral administration and this activity is seen best at a dose of 500mg/kg/day.

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Purpose: Study is part of an ongoing reverse pharmacology approach in new drug development for diabetes. It was designed to determine the potential of DB14201 to prevent the development of Streptozotocin induced Diabetes Mellitus in Wistar rats. Method: 35 female Wistar rats were randomized and allocated to different groups on the basis of body weight. G1 served as non diabetic control (Negative Control) and G2 served as Diabetic control (Vehicle Control) and received 10 ml/kg of Milli Q water. G3 and G4 were treated with 500mg/kg and 250mg/kg of DB14201 respectively. All the groups were treated orally for 21 days using disposable syringes tipped with an oral gavage needle. At the end of dosing period, hyperglycemia was induced in G2,G3 and G4 rats by intra peritoneal injection of streptozotocin (STZ) 55 mg/kg in citrate buffer (pH 4.5). Fasting blood glucose level was estimated before induction of diabetes and on 2nd & 7th days post induction. All animals were observed daily for mortality and clinical signs of toxicity throughout the experimental period. Body weight of each animal was recorded daily throughout the experimental period. On the 8th day post STZ injection, animals were killed by cervical dislocation. Their pancreatic tissues were quickly removed. Tissues were washed in normal saline and visible clots were removed to minimize blood contamination. Part of the pancreatic tissue was sent for histological evaluation. With second part of tissue, homogenates was prepared and stored at 70 A°C until the determination of biochemical parameters and enzyme activity. Result: Findings of this study strongly demonstrate that DB14201 treatment have prominent role in the prevention of STZ induced diabetes mellitus. Conclusion: Result clearly indicates the prophylactic as well as therapeutic potential of DB14201 in this experimental model. DB14201 at the dose of 500mg/kg was found to be more promising.

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Purpose: Mental disorders are high on rise in India. Epidemiological studies conducted in India on mental and behavioural disorders report varying prevalence rates, ranging from 9.5 to 370 per 1000 population. The overall DALYs burden for mental disorders is projected to increase to 15 per cent by the year 2020 and this increase is proportionately larger than that for cardiovascular diseases. Ayurveda bears great responsibility in preventing and treating the mental disorders. Medhya Rasayana is the treatment perspective to prevent and manage psychiatric disorders. In Ayurveda, Rasayana therapy has been stated as a unique therapy in curing mental diseases. It can promote memory and intelligence and can increase immunity against disease and promote strength and vitality as well as it can control ageing process by serving as anti oxidant agent. A review of various studies carried out in Ayurveda is made to enlist the best effective treatment measures in promoting and preventing mental disorders. Method: Available research works carried out at Institute for Post Graduate Teaching & Research in Ayurveda, Jamnagar from the year 2001 to 2012 are screened and referred with relation to mental disorders. The treatments are reviewed and enlisted for assessing the efficacy. Result: On reviewing the researches, it was found that nearly 15 works found suitable are carried out in relation to mental disorders. The data shows that Ayurvedic formulations like Aamalakyadi and Medhya Rasayana Ghrita (in Alzheimer's disease), Rasayana Ghana tablets (in stress), Rasona tablets, Brahmi ghrita, flax seed capsules and Ashwagandharishta (in depression), Shirodhara (in insomnia), Saraswatarishta (in perimenopausal syndrome) are effective in psychiatric diseases. Conclusion: Researches show that Ayurvedic formulations are effective in moderate manner in treating the psychiatric diseases. Ayurvedic Medhya Rasayana formulations can be used for preventing and managing psychiatric disorders.

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Purpose: Pilonidal Sinus is a one type of Nadivranan occurs at natal region, having high recurrence rate with surgery. Acharya sushruta has advocated kshara sootra chikitsa for the same. Evaluation of this management was the purpose of the study. Method: Patients were asked to lie down in left lateral position and General anesthesia was given small incision was taken at natal region and hairs were extracted and tract was scooped, another opening was created and kshara sootra was passed and it was changed till the complete excision of the tract occurred. Result: Total 133 patients are treated with this technique. Out of which 57 patients were treated in between 2005 to 2012. It was observed that out of this 57 patients 33 i.e. 58% patients reported the hospital in their 16 to 25 years of age group and 18 i.e. 31.5% patients regarded the disease in their 26 to 35 years of age. Rest 10.5% reported in later age of their life. 36 i.e. 63% patients were male and 10 i.e. 28% of male patients were having the history of previous surgery out of which one patient had underwent kshara sootra therapy still he had a recurrence of the disease. Whereas 21 i.e. 37% of female patients were reported out of which 8 i.e. 38% female patients reported recurrence of the disease. Thus it can be said that ratio of male/female had deceased & recurrence of the disease was more in female than male. Hairs were found in 24 male patients versus 3 female patients. 3 patients reported delayed healing, all the patients were cured. Conclusion: It Seems from the study that minimal sinectomy with the Ksharsootra had provided all most 100% success rate with the advantage of day care procedure cost effectiveness, Minimum days of off the work and better patients compliance with minimal complications.

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Purpose: Beauty is not in the face; Beauty is a light in the heart. In our Ayurveda it is stated that Physical, Mental and Spiritual beauty as a combined unit projects the cosmetic sense of Ayurveda (Ch.Su 1/41). According to Ayurveda healthy skin is the result of overall condition of individuals and prescribes numerous skin care treatments that need to be pursued at every stage of life.Ayurveda determines beauty by Prakruti(body constitution), Sara (structural predominance), Samhanana (compactness of body), Twak (skin complexion), Pramana (measurement) and Dirghayu lakshana (symptom of long life). Ayurveda cosmetology started with garbhini paricharya, Dinacharya, Ratricharya and Ritucharya with practice of medicinal herbs and minerals. In day-to-day life, knowingly or unknowingly we exposing lots of chemicals /toxins to our body, those spoiling our natural beauty silently, this same concept is explained in Agada tantra under concept of Dhooshivisha (Su.Ka 2/33) and Garaviasha. Method: 1.Literature review of concept related to cosmetology in relation to Agada Tantra.2. Analysis and Interpretation of mode of action of Agada yoga's in relieving the symptoms of Twak vikaras. Result: 1. Specific Agada yogas like Bilwadi Agada , Dhooshivishari Agada, Moorvadi choorna, Paarantyadi Keram shows best preventive and curative action in twak vikaras.2. Some of the Agadas like Moorvadi choona (A.hrudaya) lepas have enhansess the internal and external beauty. Conclusion: Agada tantra is not only a branch of Ayurveda it deals with management of acute and chronic diseases but also a added benefit of being used for cosmetology.

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The non availability of reliable and standardized drugs, their high cost, and ambiguity in the identity of the ingredients used are a few of the major problems encountered today in the utilization of compound drugs in Ayurveda. There is thus an urgent need to re emphasize the use of single plant drug formulations recorded in the classical texts. The present study is an attempt to list out various single plant drugs mentioned in the treatment of Apasmara (Epilepsy) from the classical texts of Ayurveda. They have been correlated with their botanical identities based on nomenclature correlation studies published over the last century. The drugs are arranged alphabetically with their botanical names, habit, indications, parts used, method of preparation, mode of administration and the reference. A primary analysis has also been made on the nomenclature, qualities and applications of the drugs.

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The diseases related to nutrition constitute the most important health problem of the world. It may be due to over nutrition in the form of obesity (Sthula) as in developed countries and due to under nutrition in the form of underweight (Karshya) as in the developing countries. It has been estimated that as many as two third of the world population suffer by under nutrition. According to Ayurvedic classics Vataja Prakriti person has lean body constitution and there is continuous degradation and aggradations in the body (Chakrapani Tika). So in person of Vataja Prakriti this phenomenon of degradation will lead to undernourishment thus resulting in difficulty for the person to cope with requirements of his life and falling prey to many disease even death. Aims and objectives: To study the effect of oral administration of "Tila Taila" in Karshya person. To include "Tila Taila" in the food for well-being of the person. Materials and methods: The study was carried out in 80 individuals of Karshya, which were divided into 2 Groups. Group A having 35 persons were treated with Tila taila and Group B having 37 persons were treated with Mahish ghrita. Result & Observations: It was found that Group A i.e. treatment with Tila taila showed highly significant results in BMI followed by Group B showing significant results in serum cholesterol. Percentage of relief in symptoms was better in Group A but statistically both group shows significant result separately. Conclusion: Maximum individuals i.e. 25% are with weight gain between 0.6 1kg. Mean change in serum cholesterol in Group A was 8.45 and in Group B was 18.27 and p value was 0.0001. Mean change in BMI in Group A was 0.43 and in Group B was 0.29 and p value was <0.05.

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Purpose: The fast changing life style of the modern era has caused increase in the pregnancy complications, anamolies etc. due to the change in the diet of pregnant women. Ayurveda has focused on this concept & have explained it very effectively. The diet of pregnant woman is not only explained according to the need of the mother but also by the fetus, which is advised monthwise (masanumasik patya). Thus, it is very necessary to promote the pregnant women to take proper diet i.e. masanumasik patya which will lead to healthly & safe motherhood along with its outcome. Method: Masanumasik patya of Ayurveda, as the name suggest, is advised according to the month & by the need of fetal development. During pregnancy. Various symptoms are faced by woman like in first trimester, nausea, vomiting is seen very comman. Thus, patya advised is madhura, shita, drava (liquid), which will prevent dehydration & supply required nourishment. In second trimester, devolepment of muscles, organs occurs, so the diet rich in proteins is advised. In third trimester retention of water, constipation is seen & finally preparation of genital tract for delivery is needed. So patyas prescribed are diuretics. Mild laxatives and basti, which will smoothen genital tract. According to Ayurvedic diets, the junk & fastfood which is prevalant now is not benificial for mother & fetus is also described. Result: As mentioned above, the diet of pregnant woman according to month is proved to se helpful for mother & fetus. Also the present diet substancescauses complication. Thus Masanumasik patya is the need of the hour. Conclusion: It is therfore clear that the diet of pregnant woman according to Ayurveda will prevent many complications of pregnancy, which will lead to healthy pregnancy & healthy fetus & finally good outcome.

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Purpose: Study is part of an ongoing reverse pharmacology approach in new drug development for diabetes. It was designed to determine the effect of DB14201 on experimentally induced uncontrolled diabetes in male Wistar rats. Method: The rats were divided in eight groups namely, (G1) Non diabetic control, (G2) diabetic control, (G3) test item 250mg/kg, (G4) test item 500 mg/kg, (G5) Metformin 500 mg/kg, (G6) Metformin 250 mg/kg, (G7) combination of T.I (250 mg/kg) and Metformin (250mg/kg) and (G8) combination of T.I (500 mg/kg) and Metformin (250mg/kg). All groups had 10 animals each except G1, the non diabetic vehicle control group, which had 5 animals. Hyperglycemia was induced in the all the animals (except G1) by intraperitoneal injection of STZ at the dose of 65mg/kg. Seven days post STZ induction; all the groups were treated orally with respective study materials for 21 days using disposable syringes tipped with an oral gavage needle. Blood glucose level, body weight, toxic signs and survival rate of animal was recorded throughout the dosing period. Result: Amongst all the DB14201 treated groups, G& i.e, combination of Metformin 250mg/kg and DB14201 250mg/kg showed maximum efficacy in lowering blood glucose level. However in the same group mortality rate was high. The body weight change throughout the study was not significant (<20%) in all the groups, which nullifies any drug related toxicity. Remarkable elevation of triglyceride levels in the diabetes induced groups give the evidence of uncontrolled diabetes. G3 i.e. DB14201 250mg/kg showed maximum survival rate at the end of the study. The relative survival percentage in this group was 150, which is the highest among the treatment groups. Conclusion: The finding of this study indicates that the test item DB14201 (250 mg/kg) is could be highly effective in terminal stage diabetes in increasing the survival rate.

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Introduction: Ayurveda, which is considered as the Panchamaveda, can be counted as the science of life existing since time immemorial. The wise and experienced authors of the Ayurvedic classics have expressed in some references that, they have only given the guidelines on the subjects to the readers. The readers are to expand the same according to their need and intelligence. There is much confusion of the Ayurvedic students and also of the practitioners and Teachers on the availability of the answers of a number of questions. Among many of such questions in the minds the authors raised a question i.e. is there any description of the signs of death/near death in the Ayurvedic classics as in the Modern texts? Methodology: To solve the question the Ayurvedic Samhitas especially Charaka Samhita and Susruta Samhita were searched thoroughly. After the thorough search of the two Samhitas it was observed that, the signs and symptoms mentioned under the heading "Maranalingani" in Charak Samhita Chikitsasthana 23rd chapter and "Asadhya Bisapidita Lakshanani" in Susruta Samhita Kalpasthana 3rd chapter resembles closely with the signs of death/near death mentioned in the modern classics, specially perikh's Textbook of Medical Jurisprudence and Toxicology. Conclusion: From the comparative study of the above mentioned descriptions it was observed that, the signs and symptoms described by Charaka and Susruta are not insufficient for a physician to give death declaration. The mentioned signs and symptoms can be used as a tool to confirm death/near death of an individual.

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Purpose: The principle aim of Ayurvedic aphrodisiac therapy Vrishya chikitsa is the birth of mentally and physically healthy children as they are the corner stones of a healthy future society. Modern life style is full of stress and competition thus interferes with physical mechanism of body creating psychosomatic impact leading to sexual inefficiency. Ayurvedic aphrodisiacs that enhance the vitality and give sexual power to couples, which enable them to give birth to healthy children. Western medicine relies on aggressive prescription of drugs and surgery to deal with many problems related to sexual dysfunction which in turn have unwanted and even dangerous side effects. In regards to this Scientists are searching for a safe and effective phytomedicine from Ayurveda. Method: Review of classical text and research data reported in various journals and monographs Result: Vrishya chikitsa described in Ashtang Ayurveda mentions the reasons for sexual inefficiency and directs the use of several aphrodisiac herbs and minerals to enhance the vitality. Charaka has prescribed the use of aphrodisiacs that enhance the potency of a person. Ex. Ashwagandha, Mushali, Shatavari, Kapikacchu etc. Researches prove that, they enhance the reproductive capabilities and vigor of men while strengthening the body and overall well-being. In Ashwagandha main contain is withanolides, which are steroid lactones and have a quick and pronounced hormonal effect, which stimulate the development of testicular cells. Kapikacchu has been shown to increase sperm count. L dopa, a precursor of the neurotransmitter dopamine, isolated from Kapikacchu, has been shown to increase sperm production. The Vrishya chikitsa resorts to herb preparations and minerals, including nonpharmacological measures mentioned by Charaka like Sadvrutta palana and Aacharrasayana, also attain to enhance reproductive capabilities and vigor of men. Conclusion: The herbs mentioned above and Sadavrutta, Achararasayana stands as an answer to solve problem of sexual inefficiency and enhance the potency of a person

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Purpose: Mukta Shukti (Pearl oyster shell); a sudha varga dravya, attains better therapeutic properties with proper sodhana and marana processes. It is indicated in Amlapitta, Parinamashoola and Annadravashoola. Acharya Susruta mentioned; Amla is the property of Vidagdha Pitta. The term Amlapitta may be correlated with Acid reflux syndrome which comprises of various types of Gastro esophageal reflux diseases like Gastritis, Peptic ulcer etc. A peptic ulcer is a sore on the lining of the stomach or duodenum, the beginning of the small intestine. A bacterium called Helicobacter pylori is a major cause of peptic ulcers. An attempt was made in this regard to establish standards to assure quality and to assess antiulcer activity of Mukta Sukti Bhasma. Method: Mukta sukti Bhasma prepared as per Rasatarangini and subjected to Atomic absorption spectroscopy (AAS) and X ray diffraction (XRD). Anti ulcer activity of Mukta sukti Bhasma in Albino rats by Aspirin induced gastric ulcer. Sucralfate as standard group and normal food water as control group used for the comparison. Result: Mukta sukti Bhasma showed highly significant Anti ulcer activity than control group. The alkaline pH and chemical components might have contributed by inhibiting secretions, neutralizing the acidity and reducing size of the ulcerative lesions. Presence of Calcium (Ca), Magnesium (Mg), Manganese (Mn), Iron (Fe), Potassium (K), Aluminum (Al), Copper (Cu), Sodium (Na) and Zinc (Zn) were detected in raw Mukta sukti and Mukta sukti Bhasma. X ray diffraction shown face centered Cubic, hexagonal, tetragonal and monoclinic crystal structures. Conclusion: In aspirin induced model, the Mukta sukti Bhasma and standard group (Sucralfate) showed highly significant Anti ulcer activity than control group (food water). The Mukta sukti Bhasma showed highly significant Anti ulcer activity than standard group (Sucralfate) when compared. This experimental study has given scientific evidence for the claim in the ancient text regarding the Anti ulcer property of Mukta sukti Bhasma which gives scope for conducting clinical study.

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Purpose: In the ancient siddha literature various herbomineral components individually and in combination are documented to have wide spectrum of activity against allergic disorders of skin like pruritus, urticaria, eczema etc. The aim of the present study was to establish the effect of G7 on IL 8, IL alpha 1 and histamine both in vivo and in vitro studies. Method: The cultured keratinocytes were exposed to uv irradiation and the release of IL 8, IL alpha 1 and histamine were established by ELISA. The effect of G7 on histamine induced wheel and flare reaction were established in human subjects. Capasicin and substance P were used as positive control with intra dermal histamine. Result: G7 had significantly interfered in the release of IL 8, IL alpha 1 and histamine in vitro studies and in vivo studies G7 had significantly reduced wheal and flare reaction in human subjects. Conclusion: The findings of the study have clearly established the anti-allergic effect of G7 and its mechanism of action. Siddha system of medicine was contemporary to ayurvedic system of medicine. Siddha system however was confined to Tamil nadu while the ayurvedic system was prevalent throughout India.

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Purpose: To standardize Palash Kshar and Nirdaha Rasa and to prove its efficacy in recanalizing Coronary Artery. Method: Ksharas was prepared by various methods from the secondary root bark of palash tree procured from Aanup Sadharan and Jangal Desh. The kshar was prepared on the basis of samhitas. Elements present in Kshar and Nirdah Rasa were analysed using Atomic Absorption Emission Spectrophotometry. During preparation, hourly pH reading showed highly alkaline solution having pH between 14 15. A placebo controlled comparative study conducted to evaluate efficacy using standardized Palash Kshar and Nirdaha Rasa in 30 patients. Result: Nirdaha Rasa was found to be more useful but the plant gets scarified because of the extraction method hence Nirdaha Rasa was obtained with tiryaak paatan yantra which yielded maximum quantity but had less mineral content. Nirdaha Rasa was for the first time prepared and standardized by the author. Numbers of experiments were performed to standardize the method of preparation of Kshar. The ideal method was found to be as per Shushrut. Atomic Absorption Emission Spectrophotometry was used to analyse prepared Kshar and Nirdaha Rasa, which showed the presence of elements like magnesium, sulphur, phosphorus, calcium, sodium, chlorine and some antioxidant and trace elements like zinc and selenium. A placebo controlled comparative study showed symptomatic relief and improvement in Stress test (n=5) and 2D echo cardiography (n=2) and reduction in LAD artery (n=2), partial recanalization of renal artery (n=1) and complete recanalization of carotid (n=2) circumflex (n=2) artery. Conclusion: It is postulated that potassium found in palash kshara plays an important role in breaking the etiopathogenesis of CAD and will be useful in recanalising coronary artery and prevent further myocardial infarction. A further analytical evaluation and statistically powered clinical study will be useful in confirming the current findings.

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Purpose: Kumari (Aloe barbadensis Mill.) is a miracle plant. In Ayurvedic Texts Kumari has raspanchaka as: Guna Guru, Snigdha, Pichhial; Rasa Tikta, Madhur; Vipaka Katu; Veerya Sheeta whereas Kanyasara has rasa panchaka as: Guna Laghu Ruksha, Teekshna; Rasa Katu; Veerya Ushna ; Vipaka Katu . On the basis of different raspanchaka comparative study has been done to analyse its effect in the management of Kashtartava. Method: 30 patients of age group 15 35 were selected randomly, group 1 (15 patients) was given Kumari Swarasa 10 ml BD and group 2 (15 patients) was given Kanyasara Vati 250 mg BD for10 days before expected commencement of Menstrual cycle for 3 menstrual cycles. Result: Group 2 showed 25.11% more relief than group I which is significant at p<0.05. (t =3.283). Kanyasara having Katu rasa and Katu vipaka which has predominance of Vayu + Agni mahaboota. It has Strotasa shodhna & Kaphahara activities due to which it removes clots, increases flow of menstrual blood and due to Ushna Virya it improves rhythmic contractions of uterus. Conclusion: In-group 1) 5 were improved it was effective in premenstrual symptoms like anorexia etc. In group 2) 5 Patients were markedly improved, 9 moderately improved in over all symptoms. Hence Kanyasara is best line of treatment in Kashtartava.

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Purpose: According to Ayurveda food is the cause for both health and diseases i.e. wholesome and unwholesome food is responsible for happiness and misery respectively. Also it is one among the three tripods of life. Beside the quality and quantity of the food it is also very much important that how it is taken because food taken in improper way can lead to various diseases. Keeping this thing in mind there are 8 factors (Aharavidhivisheshayatana) mentioned in Vimana sthana of Charak Samhita which determines the utility of the food. Upayogasamstha is the eighth factor among these which deals with the dietetic rules. Further at another place six factors which are necessary for the transformation/digestion of the food (Aharaparinamakara Bhava) are mentioned. So, the study was planned to evaluate the relation between Upayogasamstha and digestion of the food. Method: The data from various texts along with brihatrayi has been collected, compiled and analysed to get some fruitful conclusion. Result: Each factor mentioned in Upayogasamstha has some scientific reason behind it and has got direct impact on digestion of the food as well as on the health status of the person. It was found that improper taking of food has been directly mentioned as causative factor for certain diseases. Conclusion: It can be concluded that in the field of dietetics especially digestion along with factors affecting it, has been mentioned scientifically and at very minute level in Ayurveda by following this many kind of diseases arising in today's era can be prevented.

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Purpose: An estimated 15% couples are infertile. In this male factor is 30%, female factor is 30%, both factors are 30% and idiopathic causes are 10%. Among them shukra kshaya [oligospermia] is the major cause. Infertility severely affects the couple in their Psychological harmony, Sexual life and social activity. So the qualitative and quantitative increase in sukra is the main purpose of this study. Method: The study was conducted with an open trial with randomised selection. Guduchyadi pippali yoga consists of Guduchi satva, pippali churna, Ela churna, Abraka bhasma, Loha bhasma and sita and it was given in 500mg tab form mixed with honey and ksheera as anupana. This drug has been given for 45 days and patient was asked to review in every 15 days with the help of subjective parameters from the patient and objective parameters from a laboratory the results were assessed. Result: The results are encouraging in both subjective and objective parameters. Among 30 patients 5 patients reported that their partner got conceived. Conclusion: The sperm count and sperm motility are markedly improved. No side effects have been reported. Thus it finally noticed that Ayurveda has proper answer to male infertility which is caused by oligospermia. So the purpose of this study is fulfilled.

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Purpose: In the yogic system Yoganidra belong to the method of Rajayoga.It is essentially a method of Pratyahar.Yoganidra probaly relieves pain by stimulating the pituitary gland to release its own potent pain. Suppressing compound, endorphins and encephalins. These natural substances appear to be producted by the pituitary gland on secreted in to the cerebrospinal fluid, which surrounds and supports the entire central nervous system. The purpose of study to assess anti-inflammatory effect of Yoganidra on Rheumatoid arthritis. Method: I have selected 20 patients of rheumatoid arthritis at Ayurvedic & Yoga Research Institute, Motihari, Bihar for achieve the purpose. Out of 20 patients 12 patients were male and 8 patient of female. Age varied from 25 to 60 years old. These cases were subjected to a careful case taking and through physical examination modern as well as Ayurvedic Clinical Methodology. After diagnosis, each patient was subjected to the following allocated practice. Pawan muktasana Part I (Anti rheumatic group), Nadi Sodhan Pranayam (Psychic network Purification), Yoganidra. The usual course of practice was 4 weeks. Result: The practice of Yoganidra showed significant clinical relief in pain, tenderness, stiffness and swelling of the joint in all patients taken under trial. Those patients reported feeling of well being lightness in the body, improvement in mental tension, muscular tension & emotional tension. The overall result in our cases were categorised and in final analysis 40% cases got relieved, 10% case got improvement (+) 20% case got improve (++) another 20% got improving (+++) and 10% case remained incompletely assessed. Conclusion: The practice of Yoganidra on daily basis may be analgesics and anti-inflammatory affect to control pain. Thus the practice of Yoganidra can be used successfully in the management of Rheumatoid arthritis.

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Purpose: To assess the safety and efficacy of Amrita tablets in human immunodeficiency virus positive patients. Method: The randomized double blind placebo controlled trial carried out 40 HIV positive patients at Ayurvedic Drug Research Institute Motihari Bihar, with permission from Institutional Ethic Committee for achieve the purpose. Out of 40 HIV patients 30 were male and 10 patients of female. The HIV positive patients were randomly assigned to three groups A, B and C. Group A received Amrita tablet. Group B received Amritasava and group C received Placebo. The doses of Amrita tablet, two tabs. And Amritasava 10ml with one cup water twice daily for six months. The hematological investigation was repeated at the end of the study. Result: In study participants, HIV was more common in the 15 30 year's age group. Half of the enrolled patients where from the age group 42% from 30 40 years and 8% from 40 50 age group. It was observed the end of trial period of amrita tablet was marked increase in the number of CD4count and viral load reduced<300 copies/ml. It was also found gradual reduction of clinical feature of early symptomatic stage of HIV disease. Among the participants received Amritasava there was moderate increase in the number of CD4 count, but there was no difference in viral load. Participants was received placebo there was no differences in CD4 count before the six months Conclusion: Amrita tab. is an ideal herbal formulation .It contain mainly standardchemically defined Asava of Amrita (Tinospora cardifolia) ashwagandha (Withania somnifera) and yasthimadhu (Glycyrrhiza glabra). It increases in number of CD4 count and reduce viral load. It is safe and no adverse toxic effect on long therapy. Now it is necessary to evaluate the physiological activity, pharmacological property toxicity and determination of structure of amrita tab. To antiretroviral classes of drug for used in the health care systems of countries with in the Region and elsewhere in the world.

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Purpose: Ayurveda is the manual for human body. It tells how to manage this delicate machine properly. According to Sankhya theory (karya karana vada) behind every karya (action) there is karana (cause).The same theory is applied to cropping up of ailments in human body, where the etiopathology responsible for disease is known as Nidana or hetu. "Sankchheptakh kriya yog nidana pariverjanam" (Su.uttartanra. 1) The Nidana (etiopathological factors) responsible for Amavata like viruddhahara, viruddhachesta, mandagni etc. vitiates Agni and annavaha srotusa (abhyantar rog marga), thus triggering an autoimmune response. As the disease and state of aama progresses the disease afflicts the sandhi (Madhayma rog marga) with kricchasadhya or yapya prognosis. Method: Comprehensive and analytical study of Ayurvedic literature, research papers and various Journals was carried out to reach the better understanding and cause of disease. Result: Mandagni is indispensable factor for aama, so the utmost priority must be to maintain the hemostasis of Agni and clear the path (Srotus) of body, by avoiding the causative factors and following dietetic pattern as described. "Ruksha swedo............. Aamvatmayine hitani" (bhaisajya Ratnawali 26) Conclusion: It is well known that the disease Amavata is incurable and relapsing in nature. So being an Ayuvedician it should be our responsibility to redeem its normal state with the help of nidana parivarjan and judicious use of pathya apathya. It will not merely avert the disease, but also enrich public health through Ayurveda.

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Purpose: Most of India population resides in rural and are not that economically sufficient to attend to rich healthcare bills of costly medicine, therapies and laboratory tests. The government is surely upto create more health centres and aid in future, as such this is a time taking project. On the other hand, an easy and effective way is following Ayurvedic life style and measures, moreover rural India is more closer to nature and the science of life, and it is more favourable to implement the ways mentioned in Ayurveda at core level. A study to verify the ways that can be advocated, from the basics of Ayurveda was projected. Method: Simple methods like following of dinacharya, ritucharya, sad vyavahar, plantation of home remedial medicinal plants along with the prime occupation of agriculture farming, using or organic fertilizer, following the medicinal ethics in rituals, protecting off from modern disorder causatives like sedentary lifestyle, junk canned foods, synthetic fertilizers, pollutants, etc. living in close with the nature, precisely Ayurvedic living seen to be very efficient. Result: The cost of healthcare expenses and maintainence was nullified, except the genetic and traumatic disorders most of them were very well handled or controlled before attaining full-blown condition. The concept of swasthavritta, nidaan parivarjan and samprapti vighatan could control most of the diseases. Health and happiness is a gift of life, was truly experienced. Implementing simple ways, which are in chorus with the lifestyle of rural, is not a complex issue. The results are highly benefitting and puts up a golden example for other to follow. It is in tune with enriching of public health through Ayurveda. Conclusion: Rural population is the core of our country. Health to them in an economical and easy way Ayurveda will result a comprehensive progress to the whole country, and set an example for the world to follow.

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Introduction: Pre-diabetes is also known as early stage of Type 2 DM and it occupying greater significant importance in recent years by scientific community. Pre-diabetics are more prone to develop Type 2 Diabetes mellitus and its related macro & micro vascular complications. Its progression to Type 2 DM is approximately 25% over 3 to 5 years. Apathyanimittaja Prameha of Ayurveda is very near to contemporary concepts of Pre-diabetes/Type 2 Diabetes mellitus. The management of Pre-diabetes is still evolving in conventional system of medicine. In Ayurveda dietary factors are considered as an important component of genesis and management of diseases. It is quite true in case of Pre-diabetes. Based on the above hypothesis, it is decided to evaluate the efficacy of avoidance of certain dietary measures in a series of patients of Pre-diabetes. Aims and objectives: To study the hypoglycemic effect of avoidance of certain dietary measures on subjective & objectives parameters of Pre-diabetes. Materials and Methods: After thorough interrogation and laboratory investigation 40 cases of Pre-diabetics were selected from OPD and IPD of Kayachikitsa, S. S. H, IMS, BHU, on a well-set proforma. The selected patients were recruited randomly into two group viz. (A) control group and (B) Avoidance of dietary measures for a period of 1 ½ years with three months of follow ups at 6 months interval. Discussion: This study reveals that patients of Group B not only have encouraging results in terms of metabolic correction but also seems to cut off its progression to Type 2 DM. The Group B patients have showed better percentage of fall in FBS level (19.58%), in comparison to PPBS (15.12%). The overall response was better in-group B, while Group A patients were more prone to develop Type 2 DM in near future. Conclusion: The leads available from this work open new Ayurveda inspired holistic approach to the management of Pre-diabetes & prevention of Diabetes Mellitus. Besides, it also has potential to improve immune status & metabolic correction in Young Pre-diabetics.

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Purpose: To study the role of flax seed oil in hypercholesterolemia. Abnormal lipid metabolism is a main cause of dyslipidaemia, which is a major risk factor for cardiovascular disease, obesity, cholesthiasis and overall mortality. The concentration of plasma cholesterol can be regulated by cholesterol biosynthesis, removal of cholesterol from the circulation, absorption of dietary cholesterol and excretion of cholesterol via bile and faeces. In liver, such lipid accumulation initially results in fatty liver that develops fatty infiltration and in chronic stages results in damage of hepatocytes, that causes gross fatty infiltration in parenchyma cells of liver. It is well known that diet plays an important role in the control of cholesterol homeostasis. In this context, it has been reported that herbs have been used as food and for medicinal purpose for hyperlipidaemia that may be useful in reducing the risk of cardiovascular disease and alterations in liver metabolism. Method: This Study was carried out on 30 Patients of Hypercholesterolemia, of which 18 were Female and 12 were male patients. All the Patients were selected for the study after Blood Test for Complete Lipid Profile. The study was carried out at OPD level of D2S Ayurveda Clinic Jaipur an Urban Clinic, for the period of 6 Months. 2 capsules of flaxseed oil were given twice daily. Result: Result assessment according to overall response to the period and in the level of Blood reports of HDL, LDL, triglycerides. Results were analysed in form of Nil, Poor, Moderate, Good response to the treatment. It was seen that among 30 Patients 13 got Good response, 12 got Moderate response, 5 got poor response among these LDL cholesterol levels were moderately reduced, Triglycerides mildly reduced, whereas HDL cholesterol levels increased significantly. Conclusion: The current study proved the efficiency of flax seed oil on hypercholesterolemia.

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Purpose: To fulfill the global demand of medicinal plants massive cultivation of medicinal plants through organic farming in a sustainable manner is the need of the hour. It can meet the global demand, supply raw drugs to the pharmaceutical industries, conserve the threatened medicinal plants and save the environment from hazards effects. Method: Based on the observation made by the author during the Study of Medicinal Plants of Orissa in Ayurvedic Therapy (Ph.D. thesis, Utkal University, 2005), a good number of threatened medicinal plants have been recorded and preserved in the herbaria. Those species are enumerated according to International Code of Botanical Nomenclature (ICBN) along with their family, classical names, medicinal uses, and threatened category (regionally and globally). On Priority basis sustainable cultivation with appropriate agro techniques using bio fertilizer has also been incorporated. Result: Cultivation of medicinal plants in traditional methods has advantages over conservation (Insitu /exsitu) and other modern propagation technology (Bio technology) to preserve the secondary metabolites present in the plant for improving medicinal efficacy. It will also fulfill the global demand of raw drugs and suitable cash crops for farmers. Procured raw drugs will be available to the end users as well as to the pharmaceutical industries efficiently and effectively with more export potential. Ultimately, the threatened species will be conserved and lead towards protection of environmental pollution. Conclusion: Since global demands of medicinal plants exceed production, the world to day claims sustainable cultivation of medicinal plants, particularly those are at the verge of extinction. The core aspects centered on biodiversity conservation based cultivation.

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Purpose: 1. Now a day's erectile dysfunction is very common Problem among The people and available measures or managament are not up to the mark & hence this disease still having ray of hope & Ayurveda could be the solution. 2. To put forth effect of Cap. Ashwa in such way to accept the medicine in the modern era. Method: Open Uncontrolled study with 30 Sample size of age group 24 70 years treated with Cap. Ashwa 1 gm BD with milk (Shatavari, Aswagandha, gokshur, Kronchbeej 250 mg each) Parameters assessed were subjective and haematological and tolerability and International Index of erectile function (IIEF) Result: Cap. Ashwa helps to significantly increase sexual desire, increase quality and sustainability of erection, increase intravaginal ejaculatory latency time & correct the premature ejaculation. No severe adverse effect was observed and the treatment was very well tolerated and safe. Conclusion: Cap. Ashwa is Very good for erectile dysfunction (66.70%) and very safe drug. It significantly increases intravaginal ejaculatory latency time. This clinical trial must be tested on more sample size, with Controlled and multicenteric level trial.

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Malaria is one of the dreaded global killer diseases especially in the poor, forested, hilly, remote regions with little medical facilities. About 2 million malaria cases are estimated to occur in India annually as per the National malaria research institute study, but many more unreported cases also occur. Each leads to treatment cost of Rs. 1,000/ (one thousand) on average. This implies Rs. 2 billion drug market. Considering that the proposed local medicinal plants based drug will cut the treatment cost by at least 50% , the business potential with 100% replacement would be Rs. 1 billion at least. The formula is basically clinically found successful by Bombay Hospital scientists. The pharmaceutical companies do not invest in the market "at the bottom of the pyramid" due to thin margins/ loss risk. Thus, of the patented malaria medicine developed by National Research Development Council (NRDC) named "Ayush 64" (www.nrdcindia.com/pages/ayush64.htm), hardly any companies bought marketing rights or did many sales. There is huge market in N. E. India/ Africa/ S. America! Ayurveda has proven medicines to treat malaria viz. Mahasudarshan Churna, Tribhuvan kirti & Parijat vati, who treat "Visham jwara" its Ayurvedic indication. However, these are unknown, unavailable, costly & unused in the tribal areas so not popularized. Folk medicines reported, but rarely, to treat malaria include Neem, Kalmegh & Harsingar, where in a clinical study in Mumbai on 120 Malaria patients, 77% showed complete parasite eradication within 7 days of treatment with the leaf paste, and is also found safe. We also found it effective in our work in Balangir in 2011, besides also by the other NGOs in Orissa viz. Sambandh & FRLHT (www.iaim.edu.in), mainly as a prophylactic. About 30% of the family expenses today spent on Malaria treatment will be cut by about 50%, saving about Rs.2,500/ annually to spend on food, health & education. About 10% productivity will also grow, taking total benefit to Rs.4, 000/ annually, as each person per family spend lying on bed about 10 15 days in Malaria fever. This will be at a cost of just Rs. 500/ making the output: input ratio 1.5, than the total loss now! Also, local & common plants sources, simple technology ensure continued availability & low cost unlike Artemissin drug.

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Purpose: As it is well served with the same Aryan and Dravidian primarily in India has developed two cultures to protect human health and resources to suit your needs individually developed treatment methods. Who stated in Ayurveda and Siddha. Ayurveda is expanding, but Siddha could not get into the main stream. Received medical science has Siddha valuable sources resulting from human community is deprived vast majority of today. Received medical science has Siddha purpose of this study contain the main stream in is. Method: History of Aryan and Dravidian cultures, History of Indian Sciences, Rigvedas, Atharvavedas, Sangamsahitya, Charaksaamhita, Shaiva Shakta Tantra etc and public mythics present study were used as the sources. Result: The study found that the difficulty of language of obtaining siddha was not included in the main stream of Indian medication., Then the formulas of Siddha therapeutics, the global medical science not only the rich are able to. Conclusion: The study also the conclusion of this study is that Indian society during the long evolutionary journey Aryan and Dravidian cultures as Siddha and Ayurveda are also mixed in their experiences and medical sources interchange wealthy have been themselves but its originality is maintained. Which consists in the fact that the botanical worlds where Ayurveda Himalayas while the original basis Siddha medicinal seaside minerals suit their environment, chemicals, and herbs the original base. Siddha medicine even today in the poisons, minerals, and ease of purification methods are available, whose use in the current upgrade medical science and is helpful in advancement and enrichment revealed that development and use of drugs in the locality, culture and the environment is essential to keep in mind.

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Purpose: Laghu Malini Vasanta Rasa is a Vasanta Malati Kalpa with Rasaka and Maricha as main ingredients, chiefly acting on Dhatvagni with Brimhana effect. It had been quoted by 30 texts and mentioned under Jeerna Jwaradhikara. None of text had mentioned it for Madhumeha. Madhumeha is chronic disorder where Dhatvagnimandya leads to diminution of Prasada Dhatu resulting in Vataprakopa .Type 2 Diabetes Mellitus is more prevalent among other types 62.4 million in 2011.Long termed hyperglycemia in Type 2 DM results in decreased quality of life 2.263 million disability adjusted life years in India during 2004. Through present study attempt was made to evaluate efficacy of formulation (AFI part I 20:36) in Madhumeha as anti-hyperglycaemic activity of ingredients of Laghu Malini Vasanta Rasa has been recognized. Method: Open trial (CTRI registration no. CTRI/2011/11/00211) Inclusion criteria- Age group 30 60 yrs, Patients with cardinal symptoms of Madhumeha Exclusion criteria-Age group < 30 >60yrs, Accelerated HTN, Pregnant, Lactating mother, CNS complication Diagnostic criteria- Subjective criteria: Classical signs & symptoms of Madhumeha, Objective criteria: FBS(fasting blood sugar)> 126 mg/dl OR PPBSL(postprandial blood sugar level)> 200 mg/dl, Total Reg.patient- 33; completed-30; Dropped out-3, Posology with duration of treatment: 250mg tablet BD 30 min. before meal with lukewarm water for 8 weeks. Criteria for assessment: Relief in symptoms by Wilcoxson signed rank method. Unpaired t test for statistical analysis of objective parameters. Result: highly significant relief p < 0.001in symptoms Klama, Daurbalya and significant relief P<0.05in reducing urine sugar and PPBSL (postprandial blood sugar level). Conclusion: Laghu Malini Vasanta helped to improve quality of life in-patient of Madhumeha.

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Purpose: The present study is designed on the hypothesis that stress, life style and dietary habits may have an impact on ageing. It aims to explain how the Vayasthapana drugs affect premature ageing by promoting mental and physical health, longevity and also by improving immunity. The study is intended to focus on how the Vayasthapana drugs clinically help in achieving a sense of general well being. Method: The clinical study was carried out on 50 male volunteers in the age group of 45 55yrs. Vayasthapana (Amrutha, Ahbaya, Dhatri, Mukta, Jivanti, Atirasa, Mandukaparni and Punarnava) compound consisting of 8 out of 10 herbs suggested by Acharya Charaka, in the form of aqueous extract put into capsule form each of 500 mg and administered with a dosage of 2 caps thrice in a day for a period of 90 days. The bio chemical investigations, Hamilton Anxiety Rating Scale and other physical and mental health parameters were assessed before the commencement of the trial as well as at the end of 90 days. Invitro studies have been carried out to assess the antioxidant property of vayasthapana compound. Result: Invitro studies carried out have shown significant anti oxidant activity. Amongst the biological factors, an improvement in the lusture of the body, moderate relief from joint pains, muscular cramps, loss of appetite and constipation are observed. Mild relief has been observed in anxiety, stress and loss of concentration. It is observed that there is a significant increase in Hb%, RBC and Total proteins. Conclusion: Undoubtedly Rasayana chikitsa is the strength of Ayurveda to meet the upcoming challenges of age related degenerative problems. The present study has also confirmed it and the volunteers who have participated in the study have reported the feeling of well being with the improvement of bio chemical indices.

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Purpose: In Ayurveda, the diseases asmari was described under asta maha gada by Susrutha. This shows how difficult this disease to treat medically or surgically. According to modern science, various deposits of urological salts precipitate and form the calculi. The prevalence of these disease urinary calculi is about 3% of population with 1% of highly exploitable with severe agony and complications. The management in contemporary modern science is toughest approach because it may solve the problem temporarily but cannot render preventing or recurrence. Hence there is need to evaluate a better remedy. Here the kshara described by susrutha is selected and the yava kshara is chosen for study. Method: Total of 10 patients was selected from the SV ayurvedic college, Tirupati after subjecting to selection criteria based on inclusion and exclusion criteria. These 10 patients are given with yava kshara as paneeya kshara with the dose of 250 mg once in week for 4 weeks. The observations are noted and results were assessed on the basis of subjective (scoring prepared for symptomatology for pain, burning micturition, dysuria, tenderness in renal angle, haematuria, microscopic analysis of urine) and objective (kub usg) parameters. And then they are subjected for statistical validity. Result: It is found to be the yava kshara (paneeya kshara) is effective reducing the symptoms and producing remarkable benefit to patient. Conclusion: Even though it is difficult to treat the disease asmari, the yava kshara shown significant result and definitely be simple to use and cost effective management.

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Purpose: Now a day the dental and gingival diseases are more common in the society. Lack of awareness, improper maintenance of oral hygiene, excess chewing of tobaccos, change in food habits etc. are the main contributing factors for oral and gum diseases. Advancement in the field of Dantashastra is not yet sufficient to control and cure of such diseases. Sheetada is a disease of gingiva which causes bleeding from gum, pus discharge, foul smell, discoloration and recession of gum and makes troublesome to the patient, resulting systemic affection occasionally. On the other hand with a close review of ancient scriptures and past research records Bakula was found to be effective in Sheetada and selected for the study as it was an astringent, easily available, economic and non-toxic. The decoction of Bakula was well absorbed through oral mucosa; hence decoction of Bakula was selected. Keeping in view the above problems and facts the proposed research was undertaken to know the effectiveness of the drug Bakula kashaya in compare to a known control drug Chlorhexidine solution (0.2%). Method: The research was conducted by Control single blind clinical trial method. Result: After 30 days of treatment 15% in T.D.G and 25% in C.D.G got cured. 45% in T.D.G and 40% in C.D.G got maximum improvement and 40% in T.D.G and 35% in C.D.G got moderate improvement. It was found that the effect of both trial and control drug were highly significant to reduce different signs and symptoms after 30 days of treatment. Conclusion: Analysing the clinical effect derived out of study, it was revealed that effectiveness of Bakula kashaya was equally effective as Chlorhexidine. But from economic, availability and easy domestic process of preparation point of view Bakula Kashaya is a better medicinal approach in the treatment of Sheetada (Gingivitis).

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Purpose: To collect, discuss and elaborate the problem of snakebite in rural India. To give first aid measures and prevention of snakebite in rural health centre. Method: This review article is based on my personal experience and textual review collected the material about first aid measures and prevention of snakebite from brihatri, lagutri and original commentary of those. I also reviewed various modern text and websites for currant update of relevant topic. About 25,000 to 40,000 people reportedly die of snakebite in India every year, but range is likely an under estimate because of incomplete reporting. Severe flooding, by concentration of human and snake population has given rise to epidemic of snakebite in India. Mostly in rural India; snake bite is common medical emergency and an occupational hazard where farming is a major source of employment. There are at least 3000 species of snake, but only 400 species are poisonous, which means most of them is non poisonous. So most of people died due to anxiety and fear. Since rural people have to rush to nearby town and cities to get medical support, precious time is lost in traveling and in organizing support. Result: Recommended first aid measure in Snake Bite, Reassure the victim, Immobilization, Avoid manipulation of bitten area, Tourniquet. Preventions - There is various methods of preventions of snake bite which are described in full text. Conclusion: Snakebite is one of major cause of death in India. First aid measure and preventions of snake bite are essential for rural and tribal peoples due to prolonged distance of hospital from their native. Ayurveda has mentioned various first aid measure and prevention of snake bite.

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Purpose: Aacharya Charaka has mentioned the Aachara rasayana for perfect mental, physical, social, spiritual health of human being. Aachar means behavioural discipline which guides and motivates the persons to have social happiness and mental stability. In this competitive era with hectic schedules, it s the need of hour to follow Achar rasayan for leading healthy, mentally peaceful life. Today's youth are deviating themselves by improper or unethical conduct. The purpose of this study is to reveal whether the students of ayurveda, who are aware of achar rasayan are practising it & upto what extent; & secondly to establish an interrelation of achar rasayan on their physical mental health & effect on academic performance as well as social behaviour. Method: 66 students of final BAMS of Mahatma Gandhi Ayurved college, Wardha were selected for the survey by an objective questionnaire by single blind method. On the basis of answered questionnaire, the students were categorized into three groups viz; poorly following, moderately following & strongly following Achar rasayan. Also students were assessed on various observations like health status, Academic performance, Attendance, participation in co curricular & extra curricular activities, Behaviour with teachers & peers. Result: Out of 66 students, 17 who strongly followed Achar rasayan, were good at academics, enjoying good physical & mental health & friendly reputation among peers. Moderately following 36 students. had variability of students enjoying satisfactory to good physical & mental health, minor health problems, intermittent stress & few didn't have healthy peer relation. 13 students poorly followed Acharrasayan were comparatively slow learners & significant low attendance was found in 7 students due to various reasons. Conclusion: The study concludes that following Achar rasayan leads to a good physical, mental & social health.

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Purpose: Irrespective of age, Graying of hairs (pallitya) has become a crucial problem in the present era. The varied reasons like genetic factor, environmental factor, life style, faulty food habits etc. are causative factors. To overcome the problem of Pallitya many synthetic dyes are used by the community. But these dyes are having chief disadvantage of producing hypersensitivity in some individuals. The efficacy of different formulations was assessed, on the white hairs procured from Barber's Shop. After that sensitivity was tested on human being. Purpose to formulate the herbomineral natural hair Colorant, to find out the efficacy of the different groups as a natural hair colorant, to Asses the sensitivity. Method: In the present study the combination of herbomineral colorant was formulated. For that Madayantika / Heena & Mandur bhasma were common drugs in the formulation & addition of kashtaushadhi from Keshranjana Gana i.e. Aamrashthi Phala Majja, Bibhitak Phala Twak, Bhrungaraj & Neelika in different proportions was done. Group 1 Heena + Mandur bhasma + Aamrasthi Phala Majjja
Group 2 Heena + Mandur bhasma + Bibhitak phala Twaka
Group 3 Heena + Mandur
bhasma + Bhrungaraj
Group 4 Heena + Mandur bhasma + Neelika
The efficacy of different formulations was assessed, on the white hairs procured from Barber's Shop. After that sensitivity was tested on human being by applying the guase piece applied with the above formulations at under arm region. Result: Out of 4 groups, combination of Madayntika, Mandura bhasma & Neelika is found suitable hair colorant & non-sensitive to human being. Conclusion: Out of 4 groups, combination of Madayntika, Mandura bhasma & Neelika is found suitable hair colorant & non-sensitive to human being.

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Purpose: To compare the effect of shodhan purvak shaman & shaman chikitsa in management of aamvata. Method: Above study was planned in two parts conceptual & clinical For clinical part 40 patients having disease aamvata were randomly selected from opd & ipd & were divided in two groups. In shodhan purvak shaman group shodhan basti & shaman vati were given. Which was selected from classic text of ayurveda. In Shaman group only shaman yog vati was administered to the patients. Total duration of treatment in both groups was of 8 weeks. Result: Shodhan purvak shaman therapy has given complete remission in 6 patients, major improvement was found in 9 patients, 4 patients in minor improvement category and one in un improved category. In shaman therapy complete relief was found in 3 patients, major improvement in 12 patients, in minor improved category there were 5 patients no patient was found in unimproved category. Conclusion: The results thus obtained were subjected to analytical statistical techniques to compare both modes of treatments. Critical assessment of total effect of therapies on individual patient reflects that shodhan therapy along with shaman vati was more effective in pacifying the symptoms of disease aamvata & bringing down the level of disease activity also as compared to shaman therapy alone. Mode of action of drug is discussed. No side effects were seen.

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Purpose: Since the Vedic age's ayurvedic system of medicine has been known for its exemplary value in the treatment of various ailments. Diabetes is a chronic medical condition, characterized by elevated levels of blood glucose (hyperglycemia) leading to spillage of glucose into the urine. Owing to the increasing incidence of side effects associated with synthetic oral hypoglycemic agents, ayurvedic medicines have started to gain importance in antidiabetic therapy. Present study was aimed to isolate and evaluate the antidiabetic activity of phytoconstituents from Piper longum (popularly known as pipali in the ayurvedic literature) dried roots in alloxan induced diabetic mice. Method: Diabetes mellitus was induced in overnight fasted (12h) Albino mice by single intraperitonial injection of freshly prepared solution of alloxain monohydrate (150mg/kg BW) in physiological saline followed by administration of 5% glucose in their drinking water for the first 24 h to counter any initial hypoglycemia. Treatment with appropriate dose of ethanol extract of Piper longum started 7days after alloxan injection. At the end of the selected period of study the blood glucose level, body weight and lipid profile was evaluated and the data obtained was compared with those obtained for normal control and diabetic control. All the data were subjected to ANOVA test. Result: Bioactive Piper longum extract, on evaluation demonstrated significant decline in blood glucose content (P<0.05), along with significantly improved lipid profile in alloxan induced diabetic mice. Also an improvement was observed in glycogen content and serum insulin content in the mice fed on the bioactive extract compared to the control mice. The extract also was found to counteract weightloss associated with diabetes. Conclusion: The study thus concludes that Piper longum extract has a potential hypoglycemic efficacy therefore justifying its use as antidiabetic agent

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Purpose: AIDS is the deadliest disease of the decade, for which unfortunately even after several advancement in biomedical sciences, no curative treatment is available as no drug is capable of separating and recovering the motif between retro viral DNA of the host. Method: The present study has been undertaken to evaluate the role of a new herbo mineral compound (LAA01) in 18 cases suffering from AIDS after getting clearance from the Institutional Ethical committee (IEC). Criteria for assessing antiviral activity includes CD3, CD4, CD8, CD4/ CD8 ratio and viral load parameters were measured. These parameters were conducted at Biognosis an approved GLP lab in Hyderabad. Result: Pre treatment mean values of these parameters compared with LAA01 treated cases values periodically respectively given in following table. The results indicate a significant rise in CD4 counts and a significant decrease in viral load. Conclusion: It concludes that the drug Ayurvedic herbo mineral preparation LAA01 under test is not only a viridicidal (drug inhibiting the HIV replication) as is evident from decrease in HIV load, but the drug also enhanced immunity as is evident from increases in CD4 and CD8 counts and their respective percentage, which maintained the quality of life (QOL) of the patients, which needs further extensive clinical trial.

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Purpose: Allergic Asthma Tamaka swasa is one of the most distressing common diseases that affect a sizable number of world populations. Internal and external allergens such as environmental change, pollutants and unsuitable foods are believed to be the predisposing factors which sensitize the immune system of the body and trigger production of the antibody Immunoglobulin E. These result in sneezing, running nose, irritation of eyes, inflammation of bronchial mucosa and wheezing. Ayurvedic formulations such as Dasamoolakatuthrayam kwatha, Vyoshadi vatakam, Swasanandam gutika and Swasa kalpa are widely used by Ayurvedic physicians and clinically proven to have anti allergic effect. They relieve bronco spasm, airway block, sneezing and running nose. Current study was aimed at proving the efficacy of these formulations in Allergic Asthma. Method: Patients diagnosed with Allergic Asthma were chosen for clinical study. A total of 38 patients of either sex ranging from the age of 4 to 48 were selected for the study. All the patients were tested for their blood level TIgE. Most of them were found to have elevated blood level TIgE. Every patient was given Dasamoolakatuthrayam kwatha, Vyoshadi vatakam, Swasanandam gutika and Swasa kalpa orally for 6 8 weeks and the progress was observed. The observations were recorded based on subjective and objective methods. Result: It was construed from the results that the trial medicines had significantanti allergic, expectorant, bronco dilatation and overall reduction in the symptoms of Allergic Asthma in the analyzed patients. By the end of 8 weeks 16 out of 38 patients had significant recovery from the symptoms, 18 had good control of the ailment while the rest 4 displayed poor progress. Conclusion: The study vividly fortified the therapeutic efficacy of the trial drugs in the management of Allergic Asthma. Besides relieving the symptoms, the drugs significantly reduced the elevated TIgE in the blood.

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Purpose: Ayurveda is being increasingly accepted by the world for its relevance and adaptability to modern times. Development in science and technology, leads to more sedentary life styles, interest in fast food, stress and strain and physically inactivity, then it results into Obesity (Sthaulya). If it is not managed properly, he is prone to get complications like prameha, pakshaghata, Hrudroga and Hyperlipidaemia etc. In the present clinical study, the emphasis has been made to study and evolve the simple Bahiparimarjan treatment methods to treat the hyperlipidaemic Sthaulya patients. Method: All the 60 patients were selected from OPD and IPD of Ayurved Rugnalaya and Anusandhan Kendra, Akola, randomly and divided in to two groups and investigated for Hb %, TLC, DLC, ESR, URINE (routine and microscopic), lipid profile etc. before and after treatment. Group A In these group 30 patients were kept on Triphaladi Taila Abhyanga once daily. Group B in this group 30 patients were kept on Shailaiyadi Udvartana once daily. All the patients (groupwise) kept on Abhyanga and Udvartana for 5 10 minutes in every posture and sarvanga Swedana for 10 20 minutes, along with placebo orally. Result: Both treatments procedures found to be equally effective in hyperlipidaemic Sthaulya patients. Conclusion: Both the groups have shown significant results in subjective and objective parameters.

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