Ancient Science of Life

ORIGINAL ARTICLE
Year
: 2015  |  Volume : 34  |  Issue : 3  |  Page : 126--129

Nephroprotective activity of Bilvādi agada in gentamicin induced nephrotoxicity in male Wistar rats


Sangeeta Kanna1, SK Hiremath1, Banappa S Unger2 
1 Department of Agadatantra, KLEU's Shri B.M.K. Ayurveda Mahavidyalaya, Shahapur, Karna, India
2 Department of Pharmacology and Toxicology, KLE College of Pharmacy, Belgaum, Karnataka, India

Correspondence Address:
Dr. Sangeeta Kanna
Department of Agadatantra, KLEU«SQ»s Shri B.M.K. Ayurveda Mahavidyalaya, Shahapur, Belgaum, Karnataka
India

Background: Gentamicin (GM) nephrotoxicity accounts for 10-30% of the acute renal failure (ARF) among drug-induced ARF. In Ayurveda such side effects are considered as the poisonous effects of low potent poisons called gara viṣa. Bilvādi agada (BA), a classical formulation is indicated in gara viṣa and most of its ingredients have proven for their nephroprotective activity. Aim: The aim was to evaluate the effect of BA in GM-induced nephrotoxicity in male Wistar rats. Materials and Methods: BA, GM, normal saline were procured from standard companies. Settings and Designs: Eighteen male Wistar rats were randomly divided into three groups, viz. Control group which received normal saline intraperitoneal (i.p.) daily for 8 days; toxic group received GM 80 mg/kg/day i.p. for 8 days, and trial group received both GM 80 mg/kg/day i.p. and BA 216 mg/each rat weighing ~200 g orally 1 h after administration of GM. Statistics: All the values were expressed as mean ± standard error and data were analyzed by applying one-way analysis of variance followed by Dunnett«SQ»s test for multiple comparison. Results: BA treated group showed a significant change (P < 0.05) in levels of serum creatinine, urine creatinine, and urine potassium. There was no significant change (P > 0.05) seen in serum potassium, sodium, chloride, calcium and phosphorus and urine sodium, chloride in all three groups. Glomerular congestion, interstitial edema, tubular necrosis, interstitial hemorrhage was reduced in BA treated group. The results of this study indicate that BA reduces GM-induced nephrotoxicity and it may be due to anti-inflammatory, immunomodulatory, diuretic and anti-oxidant properties of drugs. Further studies are necessary to explore the exact mechanism of BA in nephroprotection.


How to cite this article:
Kanna S, Hiremath S K, Unger BS. Nephroprotective activity of Bilvādi agada in gentamicin induced nephrotoxicity in male Wistar rats.Ancient Sci Life 2015;34:126-129


How to cite this URL:
Kanna S, Hiremath S K, Unger BS. Nephroprotective activity of Bilvādi agada in gentamicin induced nephrotoxicity in male Wistar rats. Ancient Sci Life [serial online] 2015 [cited 2022 Jun 28 ];34:126-129
Available from: https://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2015;volume=34;issue=3;spage=126;epage=129;aulast=Kanna;type=0