ORIGINAL ARTICLE
Year : 2012 | Volume
: 32 | Issue : 1 | Page : 11--15
Study of Brāhmī Ghṛta and piracetam in amnesia
Kapil Deo Yadav1, K. R. C. Reddy1, Vikas Kumar2
1 Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India
2 Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University, Varanasi, India
Correspondence Address:
K. R. C. Reddy
Department of Rasa Shastra, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi
India
Objective: To compare the effect of Brāhmī Ghṛta with piracetam (a reference standard chemical) in amnesia.
Materials and Methods: Brāhmī Ghṛta contained Brāhmī (Bacopa monneri), Vacā (Acorus calamus), Kuṣṭha (Sassurea lappa), Śaṅkhapuṣpī (Convolvulos pluricalis), and Purāṇa Ghṛta, prepared as per snehapāka process. Antiamnesic activity of Brāhmī Ghṛta (400 and 800 mg/kg, p.o.) was evaluated in scopolamine (1 mg/kg, s.c.) induced amnesia in Charles Foster rats using elevated plus maze, passive avoidance, and active avoidance tests. Piracetam (500 mg/kg, p.o.) was used as standard drug. This effect was compared with standard chemical used in experimental study.
Results: Brāhmī Ghṛta - (in both doses) and piracetam-treated rats significantly reversed the effect of scopolamine in modified elevated plus maze, passive avoidance, and active avoidance tests. But there were no significant differences observed in antiamnesic activity of Brāhmī Ghṛta and standard drug.
Conclusion: Brāhmī Ghṛta and piracetam produced significant beneficial effect on scopolamine-induced amnesic effect, but no significant difference was observed in between them.
How to cite this article:
Yadav KD, Reddy K, Kumar V. Study of Brāhmī Ghṛta and piracetam in amnesia
.Ancient Sci Life 2012;32:11-15
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How to cite this URL:
Yadav KD, Reddy K, Kumar V. Study of Brāhmī Ghṛta and piracetam in amnesia
. Ancient Sci Life [serial online] 2012 [cited 2023 Jan 30 ];32:11-15
Available from: https://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=2012;volume=32;issue=1;spage=11;epage=15;aulast=Yadav;type=0 |
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