Ancient Science of Life

ARTICLE
Year
: 1995  |  Volume : 15  |  Issue : 2  |  Page : 137--139

An in vitro study on the antimicrobial effect of select heterocyclic nitrogen compounds


Y.S.R. Reddy, Sama Venkatesh, Uma Shankar Misra, B Suresh, Md Afzal Azam, M Sethuraman 
 Department of Pharmaceutical chemistry, J.S.S College of Pharmacy, Rocklands, Ooty - 643 001, India

Correspondence Address:
Y.S.R. Reddy
Department of Pharmaceutical chemistry, J.S.S College of Pharmacy, Rocklands, Ooty - 643 001
India

In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2­substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3­(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhibitory concentration (MIC) values are determined, The MIC of pyrazoles and pyrido[1,2 -a] pyrimidines are found to be 25 μg/ml to 50 μg/ml against E. Coli and 50 μg/ml against B.subtilis respectively. Both pyrazole and pyrido [1,2-a] Pyrimidines are found to be totally ineffective against C. albicans.


How to cite this article:
Reddy Y, Venkatesh S, Misra US, Suresh B, Azam M, Sethuraman M. An in vitro study on the antimicrobial effect of select heterocyclic nitrogen compounds.Ancient Sci Life 1995;15:137-139


How to cite this URL:
Reddy Y, Venkatesh S, Misra US, Suresh B, Azam M, Sethuraman M. An in vitro study on the antimicrobial effect of select heterocyclic nitrogen compounds. Ancient Sci Life [serial online] 1995 [cited 2022 Oct 7 ];15:137-139
Available from: https://www.ancientscienceoflife.org/article.asp?issn=0257-7941;year=1995;volume=15;issue=2;spage=137;epage=139;aulast=Reddy;type=0