Ancient Science of Life

: 1986  |  Volume : 5  |  Issue : 4  |  Page : 232--239

Central nervous system effects of civet

RR Varma, G Santhakumari 
 C. D. R. S. Pharmacological Unit, Department of Pharmacology, Medical College, Trivandrum - 695 011, India

Correspondence Address:
G Santhakumari
Jt. Director of Medical Education, Trivandrum - 695 011

Civet, the perineal gland secretion of Malabar Civet cat (Moschothera civettina blyth) in doses ranging from 100 to 800 mg/kg p.o. produced significant potentiation of pentobarbitone induced hypnosis, mild analgesis and anticonvulsant activities. However, it is devoid of hypothermic effect in mice and antipyretic activity in febrile rats. It also failed to produce any effect in the DQrota - rod testDQ, to influence the amphetamine toxicity in aggregated mice and in the conditioned avoidance response in trained rats. In the acute toxicity studies civet was found to be devoid of any toxic manifestations or mortality in mice upto a dose of 800 mg/kg orally.

How to cite this article:
Varma R R, Santhakumari G. Central nervous system effects of civet.Ancient Sci Life 1986;5:232-239

How to cite this URL:
Varma R R, Santhakumari G. Central nervous system effects of civet. Ancient Sci Life [serial online] 1986 [cited 2023 Mar 27 ];5:232-239
Available from:;year=1986;volume=5;issue=4;spage=232;epage=239;aulast=Varma;type=0