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ORIGINAL ARTICLE
Year : 2018  |  Volume : 37  |  Issue : 4  |  Page : 188-199

Antidiabetic and nephroprotective potential of polyherbal self-fermented Ariṣṭa formulation: Evidence-based research


1 Bioassay Laboratory Medical Research, Research and Development Centre, Healthcare Division, Emami Limited, Kolkata, West Bengal, India
2 Medical Research, Healthcare Division, Research and Development Centre, Emami Limited, Kolkata, West Bengal, India
3 Department of Pharmacology, R. G. Kar Medical College and Hospital, Kolkata, West Bengal, India
4 Department of Phytochemistry, Healthcare Division, Research and Development Centre, Emami Limited, Kolkata, West Bengal, India
5 Formulation Healthcare Division, Research and Development Centre, Emami Limited, Kolkata, West Bengal, India
6 Department of Pharmacology, Institute of Post Graduate Medical Education and Research and SSKM Hospital, Kolkata, West Bengal, India
7 Healthcare Division, Research and Development Centre, Emami Limited, Kolkata, West Bengal, India

Correspondence Address:
Dr. Satyajyoti Kanjilal
Medical Research, Healthcare Division, Research and Development Centre, Emami Limited, 13, BT Road, Kolkata - 700 056, West Bengal
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/asl.ASL_61_19

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Background: Ayurvedic Ariṣṭa preparations hold an age-old heritage in the prevention and cure of metabolic disorders and associated complications. Aim: The aim of the study was to study the antidiabetic activity of a self-fermented Ariṣṭa preparation (DB-07) and its potential in preventing or curing diabetes-induced nephropathy in experimental models. Materials and Methods: Rats with Streptozotocin-induced diabetes were used for studying the various dose effects of DB-07 (2.5, 3, and 3.5 ml/kg/day) in preventive and therapeutic treatment schedules. Metformin (500 mg/kg) was used as a standard drug. Fasting blood glucose and biochemical parameters such as blood protein, urea, uric acid, and creatinine were accessed by various biochemical tests. In vitro α-amylase and α-glucosidase inhibition assay and 2-deoxy glucose uptake assay using rat L6 myotubes were studied for determining the antidiabetic mechanism of action. Results: A dose-dependent and statistically significant effect on lowering the fasting blood glucose level was observed in both preventive and therapeutic scheduled treatments. Treatment with DB-07 significantly reversed the altered biochemical parameters and the effects were comparable to metformin-treated rats. DB-07 exhibited concentration-dependent inhibition of both α-amylase and α-glucosidase enzymes with an IC50 values of 10.93 μg/ml and 8.73 μg/ml, respectively. DB-07 also showed glucose uptake potential (ca. 70% activity at 125 μg/ml) in differentiated L6 myotubes. Conclusions: These observations have revealed the antidiabetic and nephroprotective potential of DB-07. DB-07 can be a potential herbal alternative to maintain a healthy blood glucose level and will prove useful in diabetes-associated renal complications.


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