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Year : 2017  |  Volume : 37  |  Issue : 2  |  Page : 99-101

In vitro hepatoprotective activity of a polyherbal formulation on HepG2 cell line

1 Research and Development Centre, Healthcare Division, Emami Limited, Kolkata, West Bengal, India
2 Department of Biology, Research and Development, Natural Remedies Pvt. Ltd., Bengaluru, Karnataka, India

Correspondence Address:
Satyajyoti Kanjilal
Research and Development Centre, Healthcare Division, Emami Limited, 13, BT Road, Kolkata - 700 056, West Bengal
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/asl.ASL_57_18

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Background: In Ayurveda, use of multiple herbs in a single formulation is popular and polyherbal Ayurvedic formulations are widely used as growth promoters, gastrointestinal and hepatic regulators, hepatic tonics and so on. Despite the widespread use, there is a lack of scientific evidence on their efficacy and safety. Aim: This study was undertaken to validate the efficacy by evaluating the hepatoprotective activity of one such polyherbal blend (LIVT) on HepG2 cell line. Materials and Methods: Four doses of test formulation (62.5, 125, 250 and 500 μg/ml) were tested on D-galactosamine induced HepG2 cell toxicity model. MTT assay was performed to determine the dose range for the hepatoprotective study. Results: The test formulation exhibited significant (P < 0.05) cytoprotective activity with a maximum protection of 37% at dose 62.5 μg/ml, and the activity was comparable with that of the standard, silymarin. Conclusion: The results of the present study indicate that the polyherbal blend demonstrated a significant hepatoprotective activity and could be used as an active herbal alternative for the treatment of liver ailments.

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