Anti-inflammatory effect of Śirīṣāvaleha prepared by two liquid media on carrageenan induced rat paw oedema model

Harmeet Kaur; Galib Ruknuddin; Mukesh Nariya; Biswajyoti Patgiri; Prashant Bedarkar; Pradeep Kumar Prajapati

doi:10.4103/asl.ASL_11_18

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ORIGINAL ARTICLE

Year : 2017 | Volume : 37 | Issue : 2 | Page : 81-85

Anti-inflammatory effect of Śirīṣāvaleha prepared by two liquid media on carrageenan induced rat paw oedema model

Harmeet Kaur¹, Galib Ruknuddin², Mukesh Nariya³, Biswajyoti Patgiri⁴, Prashant Bedarkar⁴, Pradeep Kumar Prajapati²
¹ Department of Rasashastra and Bhaishajya Kalpana, Desh Bhagat Ayurvedic College and Hospital, Mandi Gobindgarh, Punjab, India
² Department of Rasashastra and Bhaishajya Kalpana, All India Institute of Ayurveda, New Delhi, India
³ Department of Pharmacology, Institute for Postgraduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India
⁴ Department of Rasashastra and Bhaishajya Kalpana Including Drug Research, Institute for Postgraduate Teaching and Research in Ayurveda, Gujarat Ayurved University, Jamnagar, Gujarat, India

Correspondence Address:
Harmeet Kaur
Department of Rasashastra and Bhaishajya Kalpana, Desh Bhagat Ayurvedic College and Hospital, Mandi Gobindgarh - 147301, Punjab
India

Source of Support: None, Conflict of Interest: None

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DOI: 10.4103/asl.ASL_11_18

Background: Steroidal and non-steroidal anti-inflammatory agents have several limitations, due to which people are moving towards use of traditional medicines. Considering this, the current attempt is aimed to evaluate in vivo anti-inflammatory effect of a poly-herbal formulation Śirīṣāvaleha prepared in presence of water and Kanji (sour gruel). Kanji is anticipated to bring extraction of more principles from the raw drugs and may improve therapeutic attributes of the drug. Considering this, Kanji was used as a liquid medium for preparation of Śirīṣāvaleha and was evaluated for anti-inflammatory activity in comparison to Śirīṣāvaleha prepared with water. Materials and Methods: The activity was screened in carrageenan induced rat paw oedema model in albino rats. The raw materials were collected; authenticated and trial formulations were prepared by following standard classical guidelines. Randomly selected animals were divided into four groups of six animals each. The test drugs were administered orally at a dose of 1.8 g/kg for five days. Phenylbutazone was used as standard anti-inflammatory drug for comparison. Results: Results showed the presence of pronounced anti-inflammatory activity in Śirīṣāvaleha prepared with water (SW) followed by Śirīṣāvaleha prepared with Kanji (SK). Conclusion: Study shows that both samples of Śirīṣāvaleha have anti-inflammatory effect.

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