| ORAL PRESENTATION |
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| Year : 2012 | Volume
: 32
| Issue : 5 | Page : 46 |
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OA01.46. Effect of LAS-02, a cancero-static compound on p53 levels in cases of different types of cancers
Vandana Singh, Vinamra Sharma, Aditi Asthana, Ashok Srivastava, RC Saxena, VP Trivedi
R & D Division, Lavanya Ayurvedic Pvt. Ltd., Biotech Park, Lucknow, Pin- 226021, U.P., India
Correspondence Address:
Vandana Singh
R & D Division, Lavanya Ayurvedic Pvt. Ltd., Biotech Park, Lucknow, Pin- 226021, U.P.
India
 Source of Support: None, Conflict of Interest: None  | Check |
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Purpose: Cancer is one of the life threatening diseases spreading worldwide now a days. Oncogenes on one hand are well known to be activated by proto-oncogenes and are suppressed by tumor suppressor genes (TSG). There are different strategies for targeting to the regulation of tumor suppression gene. P53 is a most targeted gene that regulates the cell cycle and hence functions as tumor suppression to maintain the integrity of DNA.
Method: In the present study p53 was used as a parameter to evaluate the efficacy of a new herbo-mineral compound LAS02 a cancero-static compound formulated by Lavanya Ayurveda Hospital and Research Centre Lucknow, in different type of malignancies such as breast cancer, bone marrow, hepatic, ovarian, head & neck carcinoma. The serum samples were taken from the cancer patients at Lavanya Ayurvedic hospital and was tested by solid phase sandwich enzyme linked immuno-sorbent assay (ELISA).
Result: The main p53 valves before treatment more found to be 4.76 U/ml however, after treatment with our new herbo-mineral drug, the mean values of post treated p53 values were found to be significantly raised to 35.94 U/ml, which signifies the efficacy of treatment of LAS02 in enhancing the expression of p53 gene in different types of cancers.
Conclusion: p53 protein is a guard of DNA and helps in enhancing repair of the damage of DNA done by cancerous pathology. |
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