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SHORT COMMUNICATION
Year : 2012  |  Volume : 32  |  Issue : 2  |  Page : 112-115

Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study


Biomedical Services, Shree Dhootapapeshwar Ayurvedic Research Foundation, Navi Mumbai, Maharashtra, India

Correspondence Address:
Mahesh K Vahalia
Shree Dhootapapeshwar Ayurvedic Research Foundation, Veer Savarkar Chowk, Panvel, Navi Mumbai - 410 206, Maharashtra
India
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Source of Support: Shree Dhootapapeshwar Ltd., Mumbai., Conflict of Interest: None


DOI: 10.4103/0257-7941.118551

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Context: Amlapitta Mishran suspension is a poly herbal ayurvedic formulation, which has been traditionally used for acidity and gastric ulcers. Aim: The aim of this study is to evaluate the antiulcer activity of Amlapitta Mishran on non-steroidal anti-inflammatory drugs (NSAID's) -induced ulcers in the rat model. Subjects and Methods: The antiulcer activity of Amlapitta Mishran was investigated on indomethacin (100 mg/kg) NSAID's induced ulcers in rats. Effect of two different doses of Amlapitta Mishran was studied by calculating the total number of ulcers, ulcer index and percentage inhibition. Statistical Analysis Used: Data was analyzed by the Student's t-test (P < 0.05). Results: Amlapitta Mishran treated rats have shown significant (P < 0.0001) decrease in the total number of ulcers and ulcer index and significant increase in % inhibition of ulcers as compared with positive control group. Conclusion: The results indicate that Amlapitta Mishran has showed a dose dependent antiulcer activity in experimental animals and confirms ayurvedic use of Amlapitta Mishran in gastric ulcers.


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