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ARTICLE
Year : 2011  |  Volume : 30  |  Issue : 3  |  Page : 78-83

Sedative Hypnotic Activity of Manahshila (Realgar) -An Experimental Evaluation


1 Department of Rasashastra & Bhaishajya Kalpana including Drag Research, IPGT & RA, Gujarat Ayurved University, Jamnagar- 361008, Gujarat, India
2 PG Department of Rasashastra, Taranath Govt. Ayurvedic Medical College, Bellary, Karnataka, India
3 Department of Pharmacology, Vijayanagara Institute of Medical Sciences, Bellary, Karnataka, India

Correspondence Address:
Naveena Kodlady
Department of Rasashastra & Bhaishajya Kalpana including Drag Research, IPGT & RA, Gujarat Ayurved University, Jamnagar- 361008, Gujarat
India
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Source of Support: None, Conflict of Interest: None


PMID: 22557432

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Manahshila (Realgar) is one of the three major Arsenicals used in Ayurvedic therapeutics since ages. It is indicated in skin, respiratory, ophthalmic and psychological disorders. It is mentioned to be the best among Rasayanas and a good aphrodisiac. As Manahshila is indicated in Unmada (Psychological disorder); wide use of Manahshila in the formulations mentioned for psychological disorders; some of those formulations are used in treatment of sleeplessness and Ardraka (Zingiber officinale0 Roscoe) which is a commonly used Shodhana reagent of Manahshila is reported to be sedative, the potential sedative hypnotic activity is inferred and an experimental study was carried out to evaluate the sedative hypnotic activity of Manahshila. Effect of Ardraka Shodhita Manahshila (ASM) on the spontaneous motor activity of albino rats in actophotometer and on diazepam induced sleeping time was evaluated. There was a statistically significant reduction in the spontaneous motor activity (P<0.001) in the ASM treated Manahshila and there was early onset and hypnotic potentiation in the diazepam induced sleep in rats (P<0.01).


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