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Year : 2009  |  Volume : 28  |  Issue : 4  |  Page : 32-35

A Study of hepatoprotective activity of Hedyotis corymbosa. Linn, in albino rats

1 J.J.C trust sanchalit N.R Vekaria institute of pharmacy and research center, Junagadh, Gujarat -362001, India
2 K.L.E. Society's College of pharmacy, Ankola, Karnataka-581314, India
3 K.L.E. Society's College of pharmacy, Belgaum, Karnataka 590010, India

Correspondence Address:
Rajshekar Chimkode
J.J.C trust sanchalit N.R Vekaria institute of pharmacy and research center, Junagadh, Gujarat -362001
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Source of Support: None, Conflict of Interest: None

PMID: 22557330

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Hedyotis corymbosa  Linn is spreading, suffruticose annual, belongs to family Rubiaceae frequently met with in field through out India, usually during rainy season. This plant is used for their medicinal properties as a folk medicine to treat jaundice, mouth wash in toothache. Hence the present study was aimed to investigate the hepatoprotective activity of ethanolic extract of Hedyotis corymbosa  which was separated in to different fractions against carbon tetrachloride intoxification. The results indicate that, Intoxification with CCl 4  increase the levels of SGOT and SGPT. The elevated levels of SGOT and SGPTwere significantly decreased by ether and butanol fractions at P<0.001 and butanone and ethanol at p<0.05, where as petroleum ether and ethyl acetate did not shown any significant reduction in the level of SGOT and SGPT.

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