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Year : 1999  |  Volume : 19  |  Issue : 1  |  Page : 76-85

Transdermal diffusion studies of a polyherbal ointment and its tropical therapy

1 Nalanda college of pharmacy, Nalgunda, Andhra Pradesh, India
2 Department of Phytochemistry & Pharmacognosy, Sri Ramakrishna college of Pharmacy, Ramakrishna Hospital campus, Avarampalayam Road, Coimbatore - 61 044, India
3 Chaitanya Nursing Home, North Parur, Eranakulam, Kerala, India

Correspondence Address:
C Sreenivas Reddy
Nalanda college of pharmacy, Nalgunda, Andhra Pradesh
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Source of Support: None, Conflict of Interest: None

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Transdermal diffusion studies of a polyherbal ointment were carried out in vito using franz- Diffusion cell and microbial one inhibition diameter as drug release monitoring parameters. Out of the three ointment base prepared, (Hydrocarbon Base (HB), surfactant Base (SB), Surfactant Base + (Penetration Enhancer (10 % DMSO) SBPE), we observed that SBPE possesses maximum drug release capacity, as indicated by simultaneous high performance liquid chromatograph (HPLC) and microbial one inhibition monitoring studies. Clinical observations showed at SBPE was effective in cases like infected wounds, scratches and abrasions, infected scabies, pyoderma and furunculosis. The overall cure rate s 79.3% with the antimicro-bial ointmtmtent.

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