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ARTICLE
Year : 1997  |  Volume : 17  |  Issue : 1  |  Page : 41-46

Liver function enzymes at the LD50 level of water and methanol extracts of Strebulus asper


Department of Biochemistry, University of Kerela, Kariavattom P.O.,Trivandrum 695 581, Kerala

Correspondence Address:
Annie Mathai
Department of Biochemistry, University of Kerela, Kariavattom P.O.,Trivandrum 695 581, Kerala

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Source of Support: None, Conflict of Interest: None


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The LD50  of the water and methanolic extractable portion of S. asper was 230mgm/kgm body weight and 200 mgm/kgm body weight respectively. Mice treated with Saw1 and SaM1 portion of S. asper showed an increase in GOT,GPT acid phosphatase, alkaline phosphatase and β-glucuronidase in the liver after 24hrs of drug treatment, the increase being ore in SaM1 treated group. The enzyme activity slowly recovered at 48 and 72 hrs. But were not reaching the corresponding control values after 72 hrs.


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