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| Year : 1995 | Volume
: 15
| Issue : 2 | Page : 137-139 |
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An in vitro study on the antimicrobial effect of select heterocyclic nitrogen compounds
Y.S.R. Reddy, Sama Venkatesh, Uma Shankar Misra, B Suresh, Md Afzal Azam, M Sethuraman
Department of Pharmaceutical chemistry, J.S.S College of Pharmacy, Rocklands, Ooty - 643 001, India
Correspondence Address:
Y.S.R. Reddy
Department of Pharmaceutical chemistry, J.S.S College of Pharmacy, Rocklands, Ooty - 643 001
India
 Source of Support: None, Conflict of Interest: None  | Check |
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In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhibitory concentration (MIC) values are determined, The MIC of pyrazoles and pyrido[1,2 -a] pyrimidines are found to be 25 μg/ml to 50 μg/ml against E. Coli and 50 μg/ml against B.subtilis respectively. Both pyrazole and pyrido [1,2-a] Pyrimidines are found to be totally ineffective against C. albicans. |
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