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Year : 1995  |  Volume : 14  |  Issue : 4  |  Page : 253-257

Anti-pyretic activity of some plants in female Albino rats: A preliminary report

1 Department of Pharmacology, J.S.S. College of Pharmacy, Rocklands, Udhagamandalam - 643 001, T.N., India
2 Division of Medical Anthropology, Tribal Research Center, Tamil University, M. Palada, Udhagamandalm - 643 004, India
3 Survey of Medicinal Plants & Collection Unit, 112, Govt. Arts College Campus, Udhagamandalm - 643 002. T.N., India

Correspondence Address:
B Suresh
Department of Pharmacology, J.S.S. College of Pharmacy, Rocklands, Udhagamandalam - 643 001, T.N.
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Source of Support: None, Conflict of Interest: None

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Ethanolic extracts of Ailanthus exceisa (AE). Toddalia asiatica (TA) and Araucaria bidwilli (AB) were screened by the anti-pyretic activity in yeast induced hyperthermic test model in the laboratory. Dose of AE (100), TA (60) and AB (30) mg., equivalent of the plant material per kg. Body weight of the extracts were administered orally to the female albino rats. Acute toxicity and preliminary phytochemical screening were conducted for all the extracts. LD 50 values on oral administration of the extracts were found to be AE (1000), AB (350) and TA (250) mg. per kg. body weight respectively. Both the root and aerial part fractions of TA displayed a pronounced anti-pyretic activity comparable to the standard drug paracetamol. AB oleoresin fraction was also found to show anti-pyretic effect. These observations however, confirm the folk-medical practices still prevailing among the tribes.

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