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Year : 1994  |  Volume : 13  |  Issue : 3  |  Page : 213-217

Hepatotoxicity of Eugenol

1 Department of Biochemistry, P.S.G. Institute of Medical Sciences & Research, Coimbatore - 641 004, India
2 Department of Zoology, Bharathiar University, Coimbatore - 641 046, India

Correspondence Address:
Vijaya Soundran
Department of Biochemistry, P.S.G. Institute of Medical Sciences & Research, Coimbatore - 641 004
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Source of Support: None, Conflict of Interest: None

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EUGENOL a widely used pharmaceutical agent proceeds toxicity on inhalation in rats. Two different doses 20 & 30 μg/100g body weight/ day of eugenol were given intramuscularly to male albino rats for 10 days and the liver function was assessed by measuring the specific enzyme activities, and total and differential bilirubin concentration. There was an appreciable increase in total as well as differential bilirubin fractions and a dose dependent increase was noticed in the activities of alkaline phosphatase, transminases, lactate dehyrogenase with a decrease in the activity of glytamyl transferase activity, and suggesting eugenol to have a toxic effect on liver.

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