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Year : 1986  |  Volume : 6  |  Issue : 2  |  Page : 80-84

Anti - diabetic activity of the seed kernel of syzygium cumini linn

C D R S Pharmacological Unit, Medical College, Trivandrum, Kerala - 695 011, India

Correspondence Address:
G Santhakumari
Jt. Director of Medical Education, Trivandrum - 695 011
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Source of Support: None, Conflict of Interest: None

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Syzygium cumini seed kernel (aqueous suspension) was screened for its antibiadetic activity at the dose levels of 1g., 2g., 4g and 6 g/kg body weight. 4g / kg dose level was found to exhibit maximum hypoglycaemic effect (42.64%) in rabbits, 3hr. after medication. Like Tolbutamide the drug may also be promoting endogenous release of insulin. An extra pancreatic site of action of the drug cannot be ruled out, since it produced a significant decrease in the blood sugar level (17.04%) in alloxan diabetic rats.

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